ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	137/809	423/7206	7.63559430722e-34
ko04724	Glutamatergic synapse	76/809	152/7206	2.69518272647e-33
ko05033	Nicotine addiction	43/809	56/7206	2.37102657737e-30
ko04727	GABAergic synapse	55/809	110/7206	2.58835858409e-24
ko05032	Morphine addiction	54/809	110/7206	2.1461229459e-23
ko04723	Retrograde endocannabinoid signaling	66/809	175/7206	1.84700546836e-20
ko04744	Phototransduction	28/809	36/7206	2.08897764754e-20
ko04713	Circadian entrainment	57/809	136/7206	2.12991099435e-20
ko04728	Dopaminergic synapse	62/809	185/7206	2.40586012203e-16
ko04721	Synaptic vesicle cycle	37/809	80/7206	2.51624046961e-15
ko04725	Cholinergic synapse	53/809	160/7206	6.75041693663e-14
ko04742	Taste transduction	30/809	61/7206	1.47883646619e-13
ko04911	Insulin secretion	43/809	117/7206	2.9071176621e-13
ko04726	Serotonergic synapse	47/809	137/7206	4.29821213387e-13
ko04024	cAMP signaling pathway	70/809	279/7206	4.35807414424e-11
ko04740	Olfactory transduction	31/809	80/7206	1.33875247384e-10
ko04970	Salivary secretion	33/809	95/7206	9.81234506584e-10
ko05031	Amphetamine addiction	31/809	91/7206	5.45634153183e-09
ko04921	Oxytocin signaling pathway	53/809	209/7206	5.50347688933e-09
ko04261	Adrenergic signaling in cardiomyocytes	51/809	205/7206	2.6975606899e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	26/809	74/7206	4.57122655723e-08
ko04720	Long-term potentiation	31/809	99/7206	5.20455861914e-08
ko05030	Cocaine addiction	25/809	73/7206	1.47699026316e-07
ko03040	Spliceosome	1/809	145/7206	8.44729287537e-07
ko05203	Viral carcinogenesis	9/809	277/7206	1.45022217918e-06
ko05164	Influenza A	3/809	167/7206	5.45254750602e-06
ko04020	Calcium signaling pathway	54/809	265/7206	9.8775353556e-06
ko04972	Pancreatic secretion	29/809	111/7206	1.02644255667e-05
ko05162	Measles	1/809	120/7206	1.44958157368e-05
ko04120	Ubiquitin mediated proteolysis	2/809	138/7206	1.69347065572e-05
ko04540	Gap junction	31/809	128/7206	2.59879197215e-05
ko04260	Cardiac muscle contraction	26/809	98/7206	2.65205469521e-05
ko04971	Gastric acid secretion	25/809	98/7206	6.28548666078e-05
ko04925	Aldosterone synthesis and secretion	26/809	105/7206	7.11835481564e-05
ko04730	Long-term depression	21/809	78/7206	9.28915272268e-05
ko05205	Proteoglycans in cancer	12/809	271/7206	0.000110236842317
ko04022	cGMP-PKG signaling pathway	43/809	216/7206	0.000163510585699
ko05168	Herpes simplex infection	6/809	182/7206	0.000182113180576
ko05322	Systemic lupus erythematosus	4/809	151/7206	0.000202760834309
ko04514	Cell adhesion molecules (CAMs)	29/809	130/7206	0.000221885890075
ko04060	Cytokine-cytokine receptor interaction	7/809	191/7206	0.000266207828996
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	20/809	79/7206	0.000412085960261
ko04932	Non-alcoholic fatty liver disease (NAFLD)	7/809	182/7206	0.000503681752052
ko03013	RNA transport	6/809	166/7206	0.000675061792909
ko05169	Epstein-Barr virus infection	9/809	206/7206	0.000699788315006
ko04010	MAPK signaling pathway	56/809	321/7206	0.00074949066554
ko05166	HTLV-I infection	16/809	292/7206	0.000854203535962
ko04974	Protein digestion and absorption	22/809	96/7206	0.00089922149138
ko04976	Bile secretion	19/809	80/7206	0.0011576902548
ko04110	Cell cycle	5/809	145/7206	0.00123620483433
ko04621	NOD-like receptor signaling pathway	6/809	157/7206	0.00128257504341
ko04924	Renin secretion	20/809	86/7206	0.00147999666779
ko04918	Thyroid hormone synthesis	20/809	86/7206	0.00147999666779
ko05215	Prostate cancer	3/809	111/7206	0.00204536236906
ko05414	Dilated cardiomyopathy	24/809	112/7206	0.00211174739615
ko04745	Phototransduction - fly	11/809	38/7206	0.00230690082488
ko00310	Lysine degradation	1/809	73/7206	0.00257084387292
ko05161	Hepatitis B	8/809	173/7206	0.00322121207634
ko04964	Proximal tubule bicarbonate reclamation	9/809	29/7206	0.0033919191749
ko04214	Apoptosis - fly	1/809	72/7206	0.00393656561409
ko04141	Protein processing in endoplasmic reticulum	9/809	184/7206	0.00418322533055
ko03018	RNA degradation	2/809	84/7206	0.00494532867035
ko04750	Inflammatory mediator regulation of TRP channels	24/809	122/7206	0.00547462333969
ko04072	Phospholipase D signaling pathway	35/809	197/7206	0.0056486980065
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/809	59/7206	0.00565292468691
ko00564	Glycerophospholipid metabolism	3/809	99/7206	0.00573972052627
ko05211	Renal cell carcinoma	3/809	96/7206	0.00820915181401
ko04150	mTOR signaling pathway	10/809	184/7206	0.00893518497133
ko04610	Complement and coagulation cascades	2/809	79/7206	0.0106076513395
ko03008	Ribosome biogenesis in eukaryotes	2/809	79/7206	0.0106076513395
ko04371	Apelin signaling pathway	31/809	177/7206	0.0108940296993
ko04978	Mineral absorption	10/809	40/7206	0.0110513673024
ko05016	Huntington's disease	13/809	215/7206	0.0114899146935
ko04630	Jak-STAT signaling pathway	6/809	132/7206	0.0115010811833
ko00330	Arginine and proline metabolism	1/809	61/7206	0.0125199018552
ko04062	Chemokine signaling pathway	34/809	201/7206	0.0125377909754
ko04330	Notch signaling pathway	1/809	62/7206	0.0129865792118
ko05140	Leishmaniasis	2/809	75/7206	0.0150512896298
ko04217	Necroptosis	10/809	178/7206	0.0154622489188
ko05034	Alcoholism	39/809	238/7206	0.0157329925338
ko04140	Autophagy - animal	9/809	164/7206	0.0167346418503
ko00520	Amino sugar and nucleotide sugar metabolism	1/809	55/7206	0.0178521822035
ko04270	Vascular smooth muscle contraction	27/809	154/7206	0.0191787194028
ko04931	Insulin resistance	7/809	137/7206	0.01944135153
ko04014	Ras signaling pathway	44/809	279/7206	0.0197352065946
ko04966	Collecting duct acid secretion	7/809	26/7206	0.0212748717549
ko00240	Pyrimidine metabolism	5/809	110/7206	0.0216696577267
ko04064	NF-kappa B signaling pathway	4/809	96/7206	0.0222368971375
ko05220	Chronic myeloid leukemia	3/809	85/7206	0.0227261065896
ko05410	Hypertrophic cardiomyopathy (HCM)	19/809	100/7206	0.0236493064308
ko04915	Estrogen signaling pathway	23/809	131/7206	0.0252843158947
ko00280	Valine, leucine and isoleucine degradation	1/809	54/7206	0.0271501095762
ko04668	TNF signaling pathway	6/809	120/7206	0.0276991506002
ko04218	Cellular senescence	11/809	177/7206	0.029753371019
ko04550	Signaling pathways regulating pluripotency of stem cells	10/809	165/7206	0.033160393849
ko05152	Tuberculosis	12/809	187/7206	0.0340667693101
ko05202	Transcriptional misregulation in cancer	12/809	188/7206	0.0342407961512
ko04810	Regulation of actin cytoskeleton	19/809	264/7206	0.0363668478437
ko04510	Focal adhesion	17/809	240/7206	0.0373231409322
ko05224	Breast cancer	11/809	174/7206	0.0380890630065
ko04146	Peroxisome	4/809	89/7206	0.0415948580304
ko04960	Aldosterone-regulated sodium reabsorption	9/809	41/7206	0.0424448872894
ko00561	Glycerolipid metabolism	2/809	63/7206	0.0426182746629
ko04612	Antigen processing and presentation	3/809	77/7206	0.0434627533749
ko04660	T cell receptor signaling pathway	7/809	124/7206	0.0444819177087
ko05145	Toxoplasmosis	7/809	126/7206	0.044853695889
ko00830	Retinol metabolism	9/809	42/7206	0.0468800055364