ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 7/288 20/7206 7.49899722121e-06 ko04020 Calcium signaling pathway 25/288 265/7206 6.79250831792e-05 ko04750 Inflammatory mediator regulation of TRP channels 15/288 122/7206 9.54263845482e-05 ko04726 Serotonergic synapse 16/288 137/7206 0.000104431488483 ko04070 Phosphatidylinositol signaling system 14/288 112/7206 0.000136248327854 ko04710 Circadian rhythm 8/288 43/7206 0.000252625083013 ko04925 Aldosterone synthesis and secretion 13/288 105/7206 0.000259536524602 ko00350 Tyrosine metabolism 7/288 33/7206 0.000264136819566 ko00564 Glycerophospholipid metabolism 12/288 99/7206 0.00054260648965 ko04922 Glucagon signaling pathway 13/288 128/7206 0.00173130838879 ko04725 Cholinergic synapse 15/288 160/7206 0.00177204586615 ko04911 Insulin secretion 12/288 117/7206 0.002373897527 ko05031 Amphetamine addiction 10/288 91/7206 0.0032588284927 ko00360 Phenylalanine metabolism 4/288 17/7206 0.00393623961728 ko05230 Central carbon metabolism in cancer 9/288 81/7206 0.00479202898561 ko04626 Plant-pathogen interaction 4/288 18/7206 0.00490393225332 ko04137 Mitophagy - animal 9/288 82/7206 0.00519948472182 ko04960 Aldosterone-regulated sodium reabsorption 6/288 41/7206 0.00534652643274 ko04971 Gastric acid secretion 10/288 98/7206 0.00556041371081 ko03320 PPAR signaling pathway 8/288 69/7206 0.00593833782055 ko00592 alpha-Linolenic acid metabolism 4/288 19/7206 0.00601928283075 ko04022 cGMP-PKG signaling pathway 17/288 216/7206 0.00703912198079 ko04136 Autophagy - other 5/288 31/7206 0.00712032533524 ko05202 Transcriptional misregulation in cancer 1/288 188/7206 0.0072108443554 ko00010 Glycolysis / Gluconeogenesis 8/288 74/7206 0.00901989543153 ko00643 Styrene degradation 2/288 4/7206 0.00905394504073 ko04921 Oxytocin signaling pathway 16/288 209/7206 0.0110705174282 ko05231 Choline metabolism in cancer 12/288 134/7206 0.011170047333 ko04713 Circadian entrainment 12/288 136/7206 0.0117211890107 ko00561 Glycerolipid metabolism 7/288 63/7206 0.0123346935142 ko05214 Glioma 8/288 79/7206 0.0131636490248 ko04970 Salivary secretion 9/288 95/7206 0.0133059314333 ko04711 Circadian rhythm - fly 3/288 13/7206 0.013410725111 ko04976 Bile secretion 8/288 80/7206 0.014136293307 ko04080 Neuroactive ligand-receptor interaction 27/288 423/7206 0.0144448998765 ko03013 RNA transport 1/288 166/7206 0.0150251470959 ko01040 Biosynthesis of unsaturated fatty acids 4/288 25/7206 0.0162815883878 ko04745 Phototransduction - fly 5/288 38/7206 0.0167706390623 ko00590 Arachidonic acid metabolism 6/288 52/7206 0.0168088852027 ko04720 Long-term potentiation 9/288 99/7206 0.0170830901208 ko04540 Gap junction 11/288 128/7206 0.0183125235156 ko04724 Glutamatergic synapse 12/288 152/7206 0.0202344060198 ko04213 Longevity regulating pathway - multiple species 8/288 86/7206 0.0211006410853 ko04918 Thyroid hormone synthesis 8/288 86/7206 0.0211006410853 ko00362 Benzoate degradation 2/288 6/7206 0.0214622310461 ko00480 Glutathione metabolism 6/288 55/7206 0.0216820427779 ko00140 Steroid hormone biosynthesis 5/288 41/7206 0.0227344213999 ko04068 FoxO signaling pathway 13/288 167/7206 0.0242805580803 ko00051 Fructose and mannose metabolism 5/288 42/7206 0.0249913289111 ko00565 Ether lipid metabolism 5/288 42/7206 0.0249913289111 ko04146 Peroxisome 8/288 89/7206 0.025369493842 ko04114 Oocyte meiosis 11/288 139/7206 0.0262813931859 ko04964 Proximal tubule bicarbonate reclamation 4/288 29/7206 0.0269977270573 ko04024 cAMP signaling pathway 19/288 279/7206 0.0270482954969 ko04912 GnRH signaling pathway 10/288 122/7206 0.0303851923026 ko04919 Thyroid hormone signaling pathway 11/288 143/7206 0.0304497209455 ko03040 Spliceosome 1/288 145/7206 0.0312271270932 ko04110 Cell cycle 1/288 145/7206 0.0312271270932 ko04066 HIF-1 signaling pathway 10/288 123/7206 0.0313419513949 ko04270 Vascular smooth muscle contraction 12/288 154/7206 0.0333119248175 ko00620 Pyruvate metabolism 5/288 46/7206 0.0354313319616 ko00270 Cysteine and methionine metabolism 5/288 47/7206 0.0384041487718 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/288 1/7206 0.0399666944213 ko04140 Autophagy - animal 12/288 164/7206 0.0402033227639 ko00052 Galactose metabolism 4/288 33/7206 0.0411110515448 ko05200 Pathways in cancer 11/288 492/7206 0.0415557298898 ko04138 Autophagy - yeast 7/288 81/7206 0.0424647245268 ko00680 Methane metabolism 4/288 34/7206 0.0451819252478 ko00380 Tryptophan metabolism 5/288 50/7206 0.0482149734949 ko00100 Steroid biosynthesis 3/288 21/7206 0.0493375112022 ko04975 Fat digestion and absorption 4/288 35/7206 0.0494699542053 ko00500 Starch and sucrose metabolism 4/288 35/7206 0.0494699542053