ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 76/344 423/7206 1.76780518133e-25 ko05033 Nicotine addiction 25/344 56/7206 5.74823953558e-19 ko04724 Glutamatergic synapse 33/344 152/7206 8.79305633248e-14 ko04727 GABAergic synapse 25/344 110/7206 3.51902093939e-11 ko04728 Dopaminergic synapse 29/344 185/7206 1.05779563911e-08 ko04723 Retrograde endocannabinoid signaling 28/344 175/7206 1.20781565898e-08 ko05032 Morphine addiction 21/344 110/7206 3.76496492395e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 17/344 74/7206 4.45454030449e-08 ko04742 Taste transduction 15/344 61/7206 1.06824101536e-07 ko05030 Cocaine addiction 16/344 73/7206 2.24955474257e-07 ko04713 Circadian entrainment 22/344 136/7206 3.84106329396e-07 ko04721 Synaptic vesicle cycle 16/344 80/7206 8.46908647766e-07 ko04024 cAMP signaling pathway 33/344 279/7206 1.02964293796e-06 ko04726 Serotonergic synapse 21/344 137/7206 1.76530973001e-06 ko04010 MAPK signaling pathway 33/344 321/7206 2.36286552516e-05 ko04725 Cholinergic synapse 20/344 160/7206 6.80229075807e-05 ko04911 Insulin secretion 16/344 117/7206 0.000125762805626 ko04261 Adrenergic signaling in cardiomyocytes 23/344 205/7206 0.000146029739963 ko04921 Oxytocin signaling pathway 23/344 209/7206 0.000176014050555 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/344 79/7206 0.000328243640313 ko05031 Amphetamine addiction 13/344 91/7206 0.000348052519842 ko04260 Cardiac muscle contraction 13/344 98/7206 0.000721578020505 ko04720 Long-term potentiation 13/344 99/7206 0.000795665319696 ko04730 Long-term depression 11/344 78/7206 0.00109633485338 ko04060 Cytokine-cytokine receptor interaction 1/344 191/7206 0.00158025597877 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/344 14/7206 0.00348858433508 ko04540 Gap junction 14/344 128/7206 0.00483300943524 ko04621 NOD-like receptor signaling pathway 1/344 157/7206 0.00708707168688 ko05322 Systemic lupus erythematosus 1/344 151/7206 0.0104814048993 ko04964 Proximal tubule bicarbonate reclamation 5/344 29/7206 0.011098441441 ko04950 Maturity onset diabetes of the young 5/344 29/7206 0.011098441441 ko04360 Axon guidance 20/344 233/7206 0.0111491952461 ko00910 Nitrogen metabolism 4/344 19/7206 0.0111850682057 ko05168 Herpes simplex infection 2/344 182/7206 0.0125209656713 ko03040 Spliceosome 1/344 145/7206 0.0156615679677 ko05205 Proteoglycans in cancer 5/344 271/7206 0.0188995213795 ko05169 Epstein-Barr virus infection 3/344 206/7206 0.018935798411 ko05414 Dilated cardiomyopathy 11/344 112/7206 0.0215537045137 ko05410 Hypertrophic cardiomyopathy (HCM) 10/344 100/7206 0.0277769691856 ko05145 Toxoplasmosis 1/344 126/7206 0.0316442749442 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/344 15/7206 0.0319984709002 ko01200 Carbon metabolism 1/344 128/7206 0.0324471625318 ko05152 Tuberculosis 3/344 187/7206 0.0357029070459 ko04020 Calcium signaling pathway 20/344 265/7206 0.0387358550491 ko04072 Phospholipase D signaling pathway 16/344 197/7206 0.0391570591519 ko05203 Viral carcinogenesis 6/344 277/7206 0.0422913069824 ko04972 Pancreatic secretion 10/344 111/7206 0.0429196264449 ko04970 Salivary secretion 9/344 95/7206 0.0461842407997 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/344 1/7206 0.0477379961143 ko05016 Huntington's disease 4/344 215/7206 0.0485939784638 ko05166 HTLV-I infection 7/344 292/7206 0.0495390550719 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/344 182/7206 0.0498092052139