ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	210/1266	423/7206	2.3270343453e-55
ko04724	Glutamatergic synapse	91/1266	152/7206	4.15324939073e-32
ko05033	Nicotine addiction	50/1266	56/7206	8.3497734897e-32
ko05032	Morphine addiction	69/1266	110/7206	2.67904570405e-26
ko04721	Synaptic vesicle cycle	56/1266	80/7206	3.76198932761e-25
ko04727	GABAergic synapse	67/1266	110/7206	1.70448148337e-24
ko04713	Circadian entrainment	76/1266	136/7206	2.73382209024e-24
ko04728	Dopaminergic synapse	85/1266	185/7206	1.3827851198e-19
ko04725	Cholinergic synapse	75/1266	160/7206	5.03920428219e-18
ko04020	Calcium signaling pathway	104/1266	265/7206	2.60147925638e-17
ko04723	Retrograde endocannabinoid signaling	78/1266	175/7206	4.15880592071e-17
ko04024	cAMP signaling pathway	107/1266	279/7206	4.60943955788e-17
ko04742	Taste transduction	39/1266	61/7206	8.57005337077e-16
ko04911	Insulin secretion	56/1266	117/7206	2.99288952231e-14
ko04744	Phototransduction	27/1266	36/7206	5.89649189953e-14
ko04921	Oxytocin signaling pathway	81/1266	209/7206	1.80677314186e-13
ko04726	Serotonergic synapse	60/1266	137/7206	5.05498209163e-13
ko04720	Long-term potentiation	46/1266	99/7206	2.2735293491e-11
ko03040	Spliceosome	1/1266	145/7206	2.59792299997e-11
ko04740	Olfactory transduction	40/1266	80/7206	2.66287353186e-11
ko05031	Amphetamine addiction	43/1266	91/7206	5.17522866979e-11
ko04970	Salivary secretion	43/1266	95/7206	2.9316960115e-10
ko04261	Adrenergic signaling in cardiomyocytes	73/1266	205/7206	3.15610881457e-10
ko05203	Viral carcinogenesis	15/1266	277/7206	1.43366681192e-09
ko05168	Herpes simplex infection	6/1266	182/7206	4.30757987495e-09
ko04360	Axon guidance	75/1266	233/7206	3.50263145955e-08
ko04966	Collecting duct acid secretion	17/1266	26/7206	8.27389406544e-08
ko04060	Cytokine-cytokine receptor interaction	9/1266	191/7206	1.15738458491e-07
ko05030	Cocaine addiction	32/1266	73/7206	1.42034002175e-07
ko03013	RNA transport	7/1266	166/7206	2.50673939952e-07
ko04925	Aldosterone synthesis and secretion	40/1266	105/7206	4.47880230034e-07
ko04971	Gastric acid secretion	38/1266	98/7206	5.9421424428e-07
ko05164	Influenza A	8/1266	167/7206	8.93411937207e-07
ko04022	cGMP-PKG signaling pathway	67/1266	216/7206	1.04945749407e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1266	74/7206	3.16783352918e-06
ko04540	Gap junction	44/1266	128/7206	5.2368858047e-06
ko05322	Systemic lupus erythematosus	8/1266	151/7206	1.11404023989e-05
ko04924	Renin secretion	32/1266	86/7206	1.16206494075e-05
ko04260	Cardiac muscle contraction	35/1266	98/7206	1.31199493817e-05
ko04141	Protein processing in endoplasmic reticulum	12/1266	184/7206	1.31669626756e-05
ko04514	Cell adhesion molecules (CAMs)	43/1266	130/7206	1.95362115693e-05
ko05205	Proteoglycans in cancer	23/1266	271/7206	2.03160643511e-05
ko05110	Vibrio cholerae infection	25/1266	63/7206	3.21442162013e-05
ko04621	NOD-like receptor signaling pathway	10/1266	157/7206	4.79089220183e-05
ko05162	Measles	6/1266	120/7206	5.34350808848e-05
ko05169	Epstein-Barr virus infection	16/1266	206/7206	5.75137880037e-05
ko04120	Ubiquitin mediated proteolysis	8/1266	138/7206	6.26013388874e-05
ko04610	Complement and coagulation cascades	2/1266	79/7206	7.1093966632e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1266	79/7206	7.1093966632e-05
ko04010	MAPK signaling pathway	84/1266	321/7206	8.65588012572e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1266	59/7206	8.94387562896e-05
ko05140	Leishmaniasis	2/1266	75/7206	0.00010325582731
ko04064	NF-kappa B signaling pathway	4/1266	96/7206	0.000119791260231
ko04972	Pancreatic secretion	36/1266	111/7206	0.000126363711997
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1266	79/7206	0.000136034799885
ko04070	Phosphatidylinositol signaling system	36/1266	112/7206	0.000143802421916
ko05161	Hepatitis B	13/1266	173/7206	0.000163907587912
ko04110	Cell cycle	10/1266	145/7206	0.00024365663931
ko04730	Long-term depression	27/1266	78/7206	0.000251904470819
ko04745	Phototransduction - fly	16/1266	38/7206	0.000342333488053
ko04146	Peroxisome	4/1266	89/7206	0.000367325658282
ko05414	Dilated cardiomyopathy	35/1266	112/7206	0.000377419658406
ko04976	Bile secretion	27/1266	80/7206	0.000512357054945
ko00480	Glutathione metabolism	1/1266	55/7206	0.0005232111994
ko00590	Arachidonic acid metabolism	1/1266	52/7206	0.000789265830196
ko00240	Pyrimidine metabolism	7/1266	110/7206	0.000904397142938
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1266	14/7206	0.000977925146606
ko04371	Apelin signaling pathway	48/1266	177/7206	0.00129357082997
ko04626	Plant-pathogen interaction	9/1266	18/7206	0.00164560827216
ko04014	Ras signaling pathway	69/1266	279/7206	0.00219947834517
ko04964	Proximal tubule bicarbonate reclamation	12/1266	29/7206	0.00224519895186
ko01524	Platinum drug resistance	4/1266	76/7206	0.00224821230227
ko04612	Antigen processing and presentation	4/1266	77/7206	0.00226222035076
ko04915	Estrogen signaling pathway	37/1266	131/7206	0.00236285157278
ko04750	Inflammatory mediator regulation of TRP channels	35/1266	122/7206	0.00243315825939
ko05321	Inflammatory bowel disease (IBD)	2/1266	56/7206	0.0024749175333
ko05144	Malaria	1/1266	45/7206	0.00274445703324
ko00071	Fatty acid degradation	1/1266	45/7206	0.00274445703324
ko03420	Nucleotide excision repair	1/1266	46/7206	0.00280080940541
ko05145	Toxoplasmosis	10/1266	126/7206	0.00290828886015
ko04072	Phospholipase D signaling pathway	51/1266	197/7206	0.00308920176779
ko04630	Jak-STAT signaling pathway	11/1266	132/7206	0.0036370779227
ko03022	Basal transcription factors	1/1266	44/7206	0.00430748303916
ko04214	Apoptosis - fly	4/1266	72/7206	0.00457743735741
ko00310	Lysine degradation	4/1266	73/7206	0.00471357408319
ko05166	HTLV-I infection	34/1266	292/7206	0.0058617644244
ko05418	Fluid shear stress and atherosclerosis	17/1266	173/7206	0.00602747074411
ko00330	Arginine and proline metabolism	3/1266	61/7206	0.00613403607944
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1266	40/7206	0.00627115800401
ko04622	RIG-I-like receptor signaling pathway	3/1266	62/7206	0.00635214465811
ko04657	IL-17 signaling pathway	6/1266	87/7206	0.00651710840589
ko05133	Pertussis	6/1266	87/7206	0.00651710840589
ko05206	MicroRNAs in cancer	18/1266	177/7206	0.00683827756599
ko04620	Toll-like receptor signaling pathway	8/1266	100/7206	0.00804120041176
ko03018	RNA degradation	6/1266	84/7206	0.0089097814003
ko00630	Glyoxylate and dicarboxylate metabolism	1/1266	38/7206	0.00942522067876
ko04923	Regulation of lipolysis in adipocytes	23/1266	77/7206	0.00951415189841
ko05222	Small cell lung cancer	7/1266	89/7206	0.0115819934302
ko05131	Shigellosis	6/1266	82/7206	0.0123001056881
ko04640	Hematopoietic cell lineage	4/1266	64/7206	0.0128315819502
ko04115	p53 signaling pathway	5/1266	74/7206	0.0129435828272
ko04658	Th1 and Th2 cell differentiation	8/1266	96/7206	0.0145265451804
ko00982	Drug metabolism - cytochrome P450	1/1266	37/7206	0.0147629611415
ko04668	TNF signaling pathway	11/1266	120/7206	0.0148343526019
ko05215	Prostate cancer	10/1266	111/7206	0.016230956359
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1266	100/7206	0.016778747306
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1266	182/7206	0.0175253861088
ko00600	Sphingolipid metabolism	4/1266	63/7206	0.0184190891498
ko04140	Autophagy - animal	18/1266	164/7206	0.0223742755748
ko00500	Starch and sucrose metabolism	1/1266	35/7206	0.0226400705045
ko03320	PPAR signaling pathway	5/1266	69/7206	0.0245537180673
ko00380	Tryptophan metabolism	3/1266	50/7206	0.0254616788489
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1266	135/7206	0.0292318581161
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1266	15/7206	0.0345899643727
ko00260	Glycine, serine and threonine metabolism	3/1266	48/7206	0.0359073384176
ko05219	Bladder cancer	3/1266	48/7206	0.0359073384176
ko04350	TGF-beta signaling pathway	10/1266	103/7206	0.0360995597304
ko00140	Steroid hormone biosynthesis	2/1266	41/7206	0.0365291159126
ko04210	Apoptosis	21/1266	180/7206	0.0367701546772
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1266	92/7206	0.037861276359
ko04510	Focal adhesion	30/1266	240/7206	0.0380171012386
ko05320	Autoimmune thyroid disease	1/1266	29/7206	0.0478701120898
ko00280	Valine, leucine and isoleucine degradation	4/1266	54/7206	0.0481861961594
ko00562	Inositol phosphate metabolism	23/1266	89/7206	0.0486028643748