ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	63/645	152/7206	1.20254973679e-27
ko05033	Nicotine addiction	37/645	56/7206	5.22953096667e-26
ko04080	Neuroactive ligand-receptor interaction	103/645	423/7206	1.21046325952e-22
ko04728	Dopaminergic synapse	61/645	185/7206	1.21958014338e-20
ko04727	GABAergic synapse	46/645	110/7206	1.28737506498e-20
ko05032	Morphine addiction	45/645	110/7206	9.92096977024e-20
ko04723	Retrograde endocannabinoid signaling	56/645	175/7206	2.4659130062e-18
ko04713	Circadian entrainment	48/645	136/7206	8.09873750751e-18
ko04721	Synaptic vesicle cycle	34/645	80/7206	8.48854158046e-16
ko04024	cAMP signaling pathway	65/645	279/7206	1.68820859358e-13
ko04725	Cholinergic synapse	43/645	160/7206	1.90622399942e-11
ko05031	Amphetamine addiction	29/645	91/7206	5.0578937777e-10
ko04742	Taste transduction	23/645	61/7206	7.6150546606e-10
ko04911	Insulin secretion	33/645	117/7206	1.15370684857e-09
ko05030	Cocaine addiction	25/645	73/7206	1.47883260566e-09
ko04726	Serotonergic synapse	35/645	137/7206	6.48346998907e-09
ko04261	Adrenergic signaling in cardiomyocytes	44/645	205/7206	2.7927442866e-08
ko04720	Long-term potentiation	27/645	99/7206	8.28599937984e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	22/645	74/7206	2.55577201773e-07
ko04514	Cell adhesion molecules (CAMs)	31/645	130/7206	2.6154090995e-07
ko04921	Oxytocin signaling pathway	42/645	209/7206	4.08503508846e-07
ko04010	MAPK signaling pathway	55/645	321/7206	1.7864704909e-06
ko05203	Viral carcinogenesis	6/645	277/7206	4.69606642893e-06
ko04970	Salivary secretion	23/645	95/7206	7.03294439634e-06
ko03040	Spliceosome	1/645	145/7206	2.61700496031e-05
ko04060	Cytokine-cytokine receptor interaction	3/645	191/7206	2.94401806589e-05
ko04730	Long-term depression	19/645	78/7206	4.00331730412e-05
ko04925	Aldosterone synthesis and secretion	23/645	105/7206	4.01026459318e-05
ko04020	Calcium signaling pathway	44/645	265/7206	6.14484234208e-05
ko04972	Pancreatic secretion	23/645	111/7206	0.000127775051861
ko04744	Phototransduction	11/645	36/7206	0.000202848829451
ko05164	Influenza A	3/645	167/7206	0.000275080184208
ko05205	Proteoglycans in cancer	9/645	271/7206	0.000311718385238
ko05168	Herpes simplex infection	4/645	182/7206	0.000319296580201
ko04260	Cardiac muscle contraction	20/645	98/7206	0.000441947105187
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	17/645	79/7206	0.000497841196631
ko04915	Estrogen signaling pathway	24/645	131/7206	0.000566339613486
ko04022	cGMP-PKG signaling pathway	35/645	216/7206	0.000586603250513
ko04966	Collecting duct acid secretion	8/645	26/7206	0.00143482996212
ko04072	Phospholipase D signaling pathway	31/645	197/7206	0.00208877622164
ko04360	Axon guidance	35/645	233/7206	0.00218881552004
ko04120	Ubiquitin mediated proteolysis	3/645	138/7206	0.00223818160715
ko04930	Type II diabetes mellitus	12/645	54/7206	0.00244347857647
ko04621	NOD-like receptor signaling pathway	4/645	157/7206	0.00257248624408
ko05322	Systemic lupus erythematosus	4/645	151/7206	0.00349793667516
ko05034	Alcoholism	35/645	238/7206	0.0035553784966
ko03013	RNA transport	5/645	166/7206	0.0036065929265
ko04924	Renin secretion	16/645	86/7206	0.003876773596
ko04110	Cell cycle	4/645	145/7206	0.0047994282679
ko04745	Phototransduction - fly	9/645	38/7206	0.0053236794759
ko05169	Epstein-Barr virus infection	8/645	206/7206	0.00627932667295
ko05414	Dilated cardiomyopathy	19/645	112/7206	0.00651285880021
ko04971	Gastric acid secretion	17/645	98/7206	0.00675965042713
ko05166	HTLV-I infection	14/645	292/7206	0.00864744530602
ko03008	Ribosome biogenesis in eukaryotes	1/645	79/7206	0.00901254838239
ko04014	Ras signaling pathway	38/645	279/7206	0.00975406020321
ko05110	Vibrio cholerae infection	12/645	63/7206	0.0117008914319
ko04740	Olfactory transduction	14/645	80/7206	0.0154740429225
ko04962	Vasopressin-regulated water reabsorption	11/645	58/7206	0.01684417894
ko00240	Pyrimidine metabolism	3/645	110/7206	0.0171691916823
ko05010	Alzheimer's disease	28/645	202/7206	0.0172546143418
ko05215	Prostate cancer	3/645	111/7206	0.0173977558879
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/645	59/7206	0.0181380536042
ko04214	Apoptosis - fly	1/645	72/7206	0.0198016134857
ko05410	Hypertrophic cardiomyopathy (HCM)	16/645	100/7206	0.0202103580514
ko00310	Lysine degradation	1/645	73/7206	0.0203483944474
ko05161	Hepatitis B	7/645	173/7206	0.0208805196192
ko04371	Apelin signaling pathway	25/645	177/7206	0.0222552742649
ko04146	Peroxisome	2/645	89/7206	0.0228290774557
ko05162	Measles	4/645	120/7206	0.0237199681311
ko04071	Sphingolipid signaling pathway	23/645	162/7206	0.0248990136653
ko04141	Protein processing in endoplasmic reticulum	8/645	184/7206	0.0252563689273
ko04540	Gap junction	19/645	128/7206	0.027105318502
ko04070	Phosphatidylinositol signaling system	17/645	112/7206	0.0284535148531
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/645	14/7206	0.030778461192
ko04630	Jak-STAT signaling pathway	5/645	132/7206	0.0310033846336
ko04137	Mitophagy - animal	2/645	82/7206	0.0316354922332
ko04217	Necroptosis	8/645	178/7206	0.0327782050586
ko04140	Autophagy - animal	7/645	164/7206	0.0363946935774
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/645	15/7206	0.0390815441008
ko04964	Proximal tubule bicarbonate reclamation	6/645	29/7206	0.0402344987733
ko00330	Arginine and proline metabolism	1/645	61/7206	0.0406811432336
ko04330	Notch signaling pathway	1/645	62/7206	0.0411299284309
ko05120	Epithelial cell signaling in Helicobacter pylori infection	14/645	92/7206	0.0421009246847
ko04612	Antigen processing and presentation	2/645	77/7206	0.0445862150633
ko04064	NF-kappa B signaling pathway	3/645	96/7206	0.0455682814539
ko04150	mTOR signaling pathway	9/645	184/7206	0.0494694146855
ko00513	Various types of N-glycan biosynthesis	8/645	42/7206	0.0496776228263
ko04973	Carbohydrate digestion and absorption	8/645	42/7206	0.0496776228263