ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 30/271 152/7206 3.15542353535e-14 ko04080 Neuroactive ligand-receptor interaction 45/271 423/7206 1.12591841354e-10 ko04970 Salivary secretion 17/271 95/7206 6.66982017526e-08 ko04713 Circadian entrainment 20/271 136/7206 1.38940078559e-07 ko04911 Insulin secretion 18/271 117/7206 2.99308824218e-07 ko04726 Serotonergic synapse 18/271 137/7206 3.20762385748e-06 ko04070 Phosphatidylinositol signaling system 16/271 112/7206 3.79279666976e-06 ko04728 Dopaminergic synapse 21/271 185/7206 5.28234991538e-06 ko04972 Pancreatic secretion 15/271 111/7206 1.52728981387e-05 ko04727 GABAergic synapse 14/271 110/7206 5.81014394795e-05 ko04720 Long-term potentiation 13/271 99/7206 7.70106046562e-05 ko04742 Taste transduction 10/271 61/7206 7.9145839608e-05 ko04020 Calcium signaling pathway 24/271 265/7206 8.50091171902e-05 ko05031 Amphetamine addiction 12/271 91/7206 0.000139379069856 ko04925 Aldosterone synthesis and secretion 13/271 105/7206 0.000142071668345 ko04730 Long-term depression 11/271 78/7206 0.000143675885549 ko05033 Nicotine addiction 9/271 56/7206 0.000211223676864 ko04723 Retrograde endocannabinoid signaling 17/271 175/7206 0.000294200649405 ko04024 cAMP signaling pathway 23/271 279/7206 0.000329744469586 ko05032 Morphine addiction 12/271 110/7206 0.000823544123116 ko04261 Adrenergic signaling in cardiomyocytes 18/271 205/7206 0.00101779107517 ko04971 Gastric acid secretion 11/271 98/7206 0.00106423687591 ko04022 cGMP-PKG signaling pathway 18/271 216/7206 0.00146085496131 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/271 59/7206 0.00151166639588 ko04921 Oxytocin signaling pathway 17/271 209/7206 0.00247520245985 ko04540 Gap junction 12/271 128/7206 0.00305139617305 ko05203 Viral carcinogenesis 2/271 277/7206 0.00315368593818 ko04514 Cell adhesion molecules (CAMs) 12/271 130/7206 0.00346832563308 ko00562 Inositol phosphate metabolism 9/271 89/7206 0.00602331402391 ko05014 Amyotrophic lateral sclerosis (ALS) 8/271 74/7206 0.00633038816629 ko05166 HTLV-I infection 3/271 292/7206 0.00705161266755 ko05169 Epstein-Barr virus infection 1/271 206/7206 0.0076806388451 ko04725 Cholinergic synapse 13/271 160/7206 0.00911720904465 ko04721 Synaptic vesicle cycle 8/271 80/7206 0.0100415346181 ko04060 Cytokine-cytokine receptor interaction 1/271 191/7206 0.0106093812507 ko04217 Necroptosis 1/271 178/7206 0.0151420413442 ko04924 Renin secretion 8/271 86/7206 0.0151685477704 ko04964 Proximal tubule bicarbonate reclamation 4/271 29/7206 0.0221562352696 ko04014 Ras signaling pathway 18/271 279/7206 0.0232762779859 ko05160 Hepatitis C 1/271 153/7206 0.0313332604708 ko00680 Methane metabolism 4/271 34/7206 0.0374130207595 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/271 1/7206 0.0376075492647 ko04918 Thyroid hormone synthesis 7/271 86/7206 0.0424293620515 ko03040 Spliceosome 1/271 145/7206 0.0451298716104 ko05322 Systemic lupus erythematosus 1/271 151/7206 0.0468840794592 ko05205 Proteoglycans in cancer 4/271 271/7206 0.0483150557561 ko04010 MAPK signaling pathway 19/271 321/7206 0.0490169862563