ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 109/640 423/7206 1.72752946724e-26 ko04724 Glutamatergic synapse 54/640 152/7206 3.14033567085e-20 ko05032 Morphine addiction 40/640 110/7206 1.14553796274e-15 ko04713 Circadian entrainment 44/640 136/7206 5.9230699545e-15 ko04727 GABAergic synapse 39/640 110/7206 7.02923164593e-15 ko05033 Nicotine addiction 27/640 56/7206 1.49518835732e-14 ko04723 Retrograde endocannabinoid signaling 47/640 175/7206 1.63541164514e-12 ko04721 Synaptic vesicle cycle 29/640 80/7206 1.16171070474e-11 ko04020 Calcium signaling pathway 59/640 265/7206 1.31437478493e-11 ko04024 cAMP signaling pathway 61/640 279/7206 1.62221318994e-11 ko04728 Dopaminergic synapse 46/640 185/7206 5.25203233447e-11 ko04921 Oxytocin signaling pathway 48/640 209/7206 3.85375592574e-10 ko04725 Cholinergic synapse 40/640 160/7206 8.34525343602e-10 ko05031 Amphetamine addiction 28/640 91/7206 2.08133726845e-09 ko04911 Insulin secretion 32/640 117/7206 3.95412479777e-09 ko04720 Long-term potentiation 27/640 99/7206 7.04604961026e-08 ko04970 Salivary secretion 25/640 95/7206 4.55700192741e-07 ko04726 Serotonergic synapse 31/640 137/7206 7.59568164744e-07 ko04925 Aldosterone synthesis and secretion 26/640 105/7206 9.698013111e-07 ko04742 Taste transduction 18/640 61/7206 3.18498974277e-06 ko04261 Adrenergic signaling in cardiomyocytes 39/640 205/7206 4.15587324109e-06 ko04971 Gastric acid secretion 23/640 98/7206 1.07621503334e-05 ko04710 Circadian rhythm 14/640 43/7206 1.1322261922e-05 ko05030 Cocaine addiction 19/640 73/7206 1.30255044227e-05 ko05322 Systemic lupus erythematosus 1/640 151/7206 1.7666175603e-05 ko03040 Spliceosome 1/640 145/7206 4.10734018023e-05 ko04022 cGMP-PKG signaling pathway 37/640 216/7206 8.02401030505e-05 ko03010 Ribosome 1/640 129/7206 0.000127609920454 ko04070 Phosphatidylinositol signaling system 23/640 112/7206 0.000130112210306 ko04750 Inflammatory mediator regulation of TRP channels 24/640 122/7206 0.000158748161258 ko04072 Phospholipase D signaling pathway 34/640 197/7206 0.000174721790771 ko04060 Cytokine-cytokine receptor interaction 4/640 191/7206 0.000237233035904 ko05110 Vibrio cholerae infection 15/640 63/7206 0.000308285905266 ko05014 Amyotrophic lateral sclerosis (ALS) 16/640 74/7206 0.000627722970092 ko04972 Pancreatic secretion 21/640 111/7206 0.00101598677475 ko04550 Signaling pathways regulating pluripotency of stem cells 4/640 165/7206 0.00126748886715 ko03013 RNA transport 4/640 166/7206 0.00128035072774 ko05164 Influenza A 4/640 167/7206 0.00130192713459 ko04350 TGF-beta signaling pathway 1/640 103/7206 0.00133742889703 ko04966 Collecting duct acid secretion 8/640 26/7206 0.00136377413686 ko04514 Cell adhesion molecules (CAMs) 23/640 130/7206 0.00146241918975 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/640 59/7206 0.0016547855855 ko04010 MAPK signaling pathway 45/640 321/7206 0.00176063060202 ko04730 Long-term depression 16/640 78/7206 0.00182693844343 ko04120 Ubiquitin mediated proteolysis 3/640 138/7206 0.00222306830892 ko04930 Type II diabetes mellitus 12/640 54/7206 0.00228818918807 ko04922 Glucagon signaling pathway 22/640 128/7206 0.00241194758752 ko04540 Gap junction 22/640 128/7206 0.00241194758752 ko04510 Focal adhesion 9/640 240/7206 0.00253576243781 ko04371 Apelin signaling pathway 27/640 177/7206 0.00465657287498 ko04110 Cell cycle 4/640 145/7206 0.00479799971013 ko05203 Viral carcinogenesis 12/640 277/7206 0.00483364838794 ko02010 ABC transporters 9/640 39/7206 0.00606935894012 ko04915 Estrogen signaling pathway 21/640 131/7206 0.00750314744728 ko00680 Methane metabolism 8/640 34/7206 0.00840730623897 ko05162 Measles 3/640 120/7206 0.00880058381054 ko04810 Regulation of actin cytoskeleton 12/640 264/7206 0.0106883568886 ko04924 Renin secretion 15/640 86/7206 0.011151340195 ko05414 Dilated cardiomyopathy 18/640 112/7206 0.0113982937414 ko04740 Olfactory transduction 14/640 80/7206 0.0150588107248 ko05205 Proteoglycans in cancer 13/640 271/7206 0.0159671784589 ko04745 Phototransduction - fly 8/640 38/7206 0.0165379991866 ko00240 Pyrimidine metabolism 3/640 110/7206 0.017089001857 ko05215 Prostate cancer 3/640 111/7206 0.0172306420984 ko05224 Breast cancer 7/640 174/7206 0.0208538602482 ko04918 Thyroid hormone synthesis 14/640 86/7206 0.0215424762779 ko04711 Circadian rhythm - fly 4/640 13/7206 0.0230107485557 ko04923 Regulation of lipolysis in adipocytes 13/640 77/7206 0.0235603635534 ko00650 Butanoate metabolism 6/640 26/7206 0.0236539571702 ko04141 Protein processing in endoplasmic reticulum 8/640 184/7206 0.0251620174506 ko04976 Bile secretion 13/640 80/7206 0.0280483277583 ko04138 Autophagy - yeast 13/640 81/7206 0.0299152839452 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/640 14/7206 0.0300060452695 ko00430 Taurine and hypotaurine metabolism 4/640 14/7206 0.0300060452695 ko04260 Cardiac muscle contraction 15/640 98/7206 0.0312556050762 ko05212 Pancreatic cancer 2/640 83/7206 0.031714742626 ko05131 Shigellosis 2/640 82/7206 0.031715252871 ko00010 Glycolysis / Gluconeogenesis 12/640 74/7206 0.036954217432 ko02024 Quorum sensing 4/640 15/7206 0.0381218344487 ko04964 Proximal tubule bicarbonate reclamation 6/640 29/7206 0.0389382379851 ko04270 Vascular smooth muscle contraction 21/640 154/7206 0.0439514581305 ko05169 Epstein-Barr virus infection 10/640 206/7206 0.0453786569705