ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 41/500 191/7206 3.61952101594e-11 ko04380 Osteoclast differentiation 26/500 134/7206 1.23892048011e-06 ko05321 Inflammatory bowel disease (IBD) 15/500 56/7206 3.84755278974e-06 ko04672 Intestinal immune network for IgA production 12/500 37/7206 4.07189666834e-06 ko04933 AGE-RAGE signaling pathway in diabetic complications 24/500 135/7206 1.5336771135e-05 ko04710 Circadian rhythm 12/500 43/7206 2.29544731611e-05 ko04621 NOD-like receptor signaling pathway 26/500 157/7206 3.61408142564e-05 ko05140 Leishmaniasis 16/500 75/7206 4.21011718414e-05 ko04610 Complement and coagulation cascades 16/500 79/7206 8.19564674648e-05 ko04659 Th17 cell differentiation 19/500 106/7206 0.000104910701505 ko03013 RNA transport 1/500 166/7206 0.000144836922257 ko00120 Primary bile acid biosynthesis 7/500 20/7206 0.000259679683445 ko05164 Influenza A 25/500 167/7206 0.00026649105253 ko04658 Th1 and Th2 cell differentiation 17/500 96/7206 0.000279337113048 ko04650 Natural killer cell mediated cytotoxicity 17/500 97/7206 0.000317462499983 ko05145 Toxoplasmosis 20/500 126/7206 0.000490704716321 ko05152 Tuberculosis 26/500 187/7206 0.000620805418757 ko03040 Spliceosome 1/500 145/7206 0.000703272347651 ko05340 Primary immunodeficiency 8/500 30/7206 0.00075993347366 ko04064 NF-kappa B signaling pathway 16/500 96/7206 0.000839402197976 ko04662 B cell receptor signaling pathway 15/500 88/7206 0.000952368790352 ko05034 Alcoholism 5/500 238/7206 0.00106664910478 ko00592 alpha-Linolenic acid metabolism 6/500 19/7206 0.00134709022465 ko04072 Phospholipase D signaling pathway 26/500 197/7206 0.00146268658203 ko05162 Measles 18/500 120/7206 0.00162153353147 ko04670 Leukocyte transendothelial migration 21/500 151/7206 0.00184620278209 ko04070 Phosphatidylinositol signaling system 17/500 112/7206 0.00201094429909 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/500 191/7206 0.00205424420841 ko03010 Ribosome 1/500 129/7206 0.00228371252809 ko04611 Platelet activation 22/500 163/7206 0.002529486923 ko00590 Arachidonic acid metabolism 10/500 52/7206 0.00264337111088 ko05160 Hepatitis C 21/500 153/7206 0.00311055596038 ko04217 Necroptosis 23/500 178/7206 0.00389430501083 ko04620 Toll-like receptor signaling pathway 15/500 100/7206 0.00424013740772 ko05323 Rheumatoid arthritis 14/500 89/7206 0.00464176706108 ko04630 Jak-STAT signaling pathway 18/500 132/7206 0.00500056075809 ko00140 Steroid hormone biosynthesis 8/500 41/7206 0.00632346971151 ko00051 Fructose and mannose metabolism 8/500 42/7206 0.0073499521396 ko03320 PPAR signaling pathway 11/500 69/7206 0.00742093848257 ko00330 Arginine and proline metabolism 10/500 61/7206 0.00860987256464 ko04668 TNF signaling pathway 16/500 120/7206 0.010115359642 ko04664 Fc epsilon RI signaling pathway 12/500 77/7206 0.0101711107876 ko05150 Staphylococcus aureus infection 7/500 36/7206 0.0106280952004 ko05144 Malaria 8/500 45/7206 0.0111865779378 ko04110 Cell cycle 3/500 145/7206 0.012952664535 ko05161 Hepatitis B 21/500 173/7206 0.0140227233149 ko04066 HIF-1 signaling pathway 16/500 123/7206 0.0177525393165 ko04660 T cell receptor signaling pathway 16/500 124/7206 0.0181686382386 ko04111 Cell cycle - yeast 1/500 90/7206 0.0203400027926 ko04391 Hippo signaling pathway - fly 1/500 90/7206 0.0203400027926 ko03015 mRNA surveillance pathway 1/500 93/7206 0.0210384062193 ko05330 Allograft rejection 5/500 24/7206 0.0222749822329 ko00565 Ether lipid metabolism 7/500 42/7206 0.0240201933417 ko00350 Tyrosine metabolism 6/500 33/7206 0.024083551995 ko00564 Glycerophospholipid metabolism 13/500 99/7206 0.0252773990603 ko05230 Central carbon metabolism in cancer 11/500 81/7206 0.0262460477121 ko05310 Asthma 4/500 17/7206 0.0264033454198 ko04068 FoxO signaling pathway 19/500 167/7206 0.0298381483877 ko00562 Inositol phosphate metabolism 12/500 89/7206 0.0316632129933 ko05231 Choline metabolism in cancer 16/500 134/7206 0.0366001429025 ko04622 RIG-I-like receptor signaling pathway 9/500 62/7206 0.0374783659002 ko00982 Drug metabolism - cytochrome P450 6/500 37/7206 0.040070829688 ko04640 Hematopoietic cell lineage 9/500 64/7206 0.0412294984262 ko05132 Salmonella infection 12/500 98/7206 0.0447880692084 ko05418 Fluid shear stress and atherosclerosis 19/500 173/7206 0.0467970223254 ko05320 Autoimmune thyroid disease 5/500 29/7206 0.0468887626719