ko pathway ratio_in_study ratio_in_pop p_value ko04713 Circadian entrainment 38/734 136/7206 3.56773084856e-09 ko04080 Neuroactive ligand-receptor interaction 80/734 423/7206 2.80487698188e-08 ko04724 Glutamatergic synapse 39/734 152/7206 3.02139215501e-08 ko04020 Calcium signaling pathway 55/734 265/7206 2.15387217072e-07 ko04921 Oxytocin signaling pathway 46/734 209/7206 3.08987329589e-07 ko05031 Amphetamine addiction 26/734 91/7206 6.74869906372e-07 ko04728 Dopaminergic synapse 41/734 185/7206 1.45248160783e-06 ko04070 Phosphatidylinositol signaling system 29/734 112/7206 1.48232521126e-06 ko04911 Insulin secretion 29/734 117/7206 3.85434364652e-06 ko04720 Long-term potentiation 26/734 99/7206 3.88196787804e-06 ko03040 Spliceosome 1/734 145/7206 4.82378835161e-06 ko04745 Phototransduction - fly 14/734 38/7206 1.07377606474e-05 ko04925 Aldosterone synthesis and secretion 26/734 105/7206 1.23894206176e-05 ko04022 cGMP-PKG signaling pathway 43/734 216/7206 1.64246061329e-05 ko04970 Salivary secretion 24/734 95/7206 1.8573462647e-05 ko04726 Serotonergic synapse 31/734 137/7206 1.94271233436e-05 ko03010 Ribosome 1/734 129/7206 2.38630375308e-05 ko04971 Gastric acid secretion 24/734 98/7206 3.2383482253e-05 ko04727 GABAergic synapse 26/734 110/7206 3.66188705308e-05 ko04922 Glucagon signaling pathway 29/734 128/7206 3.97339910345e-05 ko04730 Long-term depression 20/734 78/7206 7.28332081122e-05 ko05032 Morphine addiction 25/734 110/7206 9.12961057301e-05 ko05033 Nicotine addiction 16/734 56/7206 9.52367358588e-05 ko04514 Cell adhesion molecules (CAMs) 28/734 130/7206 0.000101361340669 ko03013 RNA transport 4/734 166/7206 0.000215316145203 ko04710 Circadian rhythm 13/734 43/7206 0.000229963352175 ko04924 Renin secretion 20/734 86/7206 0.000398484805187 ko04725 Cholinergic synapse 31/734 160/7206 0.000465832908045 ko04261 Adrenergic signaling in cardiomyocytes 37/734 205/7206 0.000574764687278 ko04024 cAMP signaling pathway 46/734 279/7206 0.000813252342341 ko04110 Cell cycle 4/734 145/7206 0.00120497191473 ko04626 Plant-pathogen interaction 7/734 18/7206 0.00128552091832 ko04371 Apelin signaling pathway 32/734 177/7206 0.00142840332925 ko05322 Systemic lupus erythematosus 5/734 151/7206 0.00249593285604 ko05014 Amyotrophic lateral sclerosis (ALS) 16/734 74/7206 0.00302383488243 ko05203 Viral carcinogenesis 14/734 277/7206 0.00308188164238 ko04137 Mitophagy - animal 17/734 82/7206 0.00468421323845 ko05224 Breast cancer 7/734 174/7206 0.00478379812652 ko04960 Aldosterone-regulated sodium reabsorption 10/734 41/7206 0.00678257502684 ko05169 Epstein-Barr virus infection 10/734 206/7206 0.00704718550016 ko04540 Gap junction 23/734 128/7206 0.00709353416712 ko04138 Autophagy - yeast 16/734 81/7206 0.00846607040505 ko04270 Vascular smooth muscle contraction 26/734 154/7206 0.00972958207216 ko04650 Natural killer cell mediated cytotoxicity 18/734 97/7206 0.0103980501172 ko04136 Autophagy - other 8/734 31/7206 0.0105060670666 ko04966 Collecting duct acid secretion 7/734 26/7206 0.0129079419622 ko04015 Rap1 signaling pathway 41/734 278/7206 0.0147413353948 ko04750 Inflammatory mediator regulation of TRP channels 21/734 122/7206 0.0148374021653 ko04014 Ras signaling pathway 41/734 279/7206 0.0150122891432 ko04723 Retrograde endocannabinoid signaling 28/734 175/7206 0.0154155351493 ko05030 Cocaine addiction 14/734 73/7206 0.017751500739 ko00680 Methane metabolism 8/734 34/7206 0.0184195817501 ko00010 Glycolysis / Gluconeogenesis 14/734 74/7206 0.0191594659064 ko00562 Inositol phosphate metabolism 16/734 89/7206 0.0208657186308 ko05130 Pathogenic Escherichia coli infection 2/734 77/7206 0.0216570459079 ko04114 Oocyte meiosis 23/734 139/7206 0.0220664300991 ko00620 Pyruvate metabolism 10/734 46/7206 0.0225337856625 ko04721 Synaptic vesicle cycle 15/734 80/7206 0.023063932484 ko04964 Proximal tubule bicarbonate reclamation 7/734 29/7206 0.0234335390917 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/734 191/7206 0.0281278469126 ko00564 Glycerophospholipid metabolism 17/734 99/7206 0.0283197778427 ko05200 Pathways in cancer 36/734 492/7206 0.0302795707885 ko04520 Adherens junction 4/734 103/7206 0.0315074340384 ko04657 IL-17 signaling pathway 3/734 87/7206 0.0317115299016 ko05110 Vibrio cholerae infection 12/734 63/7206 0.032587734695 ko00051 Fructose and mannose metabolism 9/734 42/7206 0.0339612045452 ko04141 Protein processing in endoplasmic reticulum 10/734 184/7206 0.0345866344347 ko04611 Platelet activation 25/734 163/7206 0.0351899536326 ko00592 alpha-Linolenic acid metabolism 5/734 19/7206 0.0375147034303 ko04740 Olfactory transduction 14/734 80/7206 0.0390500155533 ko04011 MAPK signaling pathway - yeast 1/734 53/7206 0.0393245515477 ko03050 Proteasome 1/734 54/7206 0.039595601974 ko04972 Pancreatic secretion 18/734 111/7206 0.0397853018755 ko04072 Phospholipase D signaling pathway 29/734 197/7206 0.0413303054479 ko05217 Basal cell carcinoma 2/734 68/7206 0.0432991055469 ko00120 Primary bile acid biosynthesis 5/734 20/7206 0.0459682275925 ko04360 Axon guidance 33/734 233/7206 0.0470751362538