ko pathway ratio_in_study ratio_in_pop p_value ko03030 DNA replication 21/323 38/7206 3.6516337203e-19 ko03040 Spliceosome 34/323 145/7206 4.5384390134e-16 ko03008 Ribosome biogenesis in eukaryotes 22/323 79/7206 2.03511774061e-12 ko04110 Cell cycle 26/323 145/7206 8.99899667941e-10 ko03440 Homologous recombination 13/323 41/7206 1.31239683255e-08 ko03013 RNA transport 25/323 166/7206 7.46023713748e-08 ko03460 Fanconi anemia pathway 13/323 51/7206 2.36123873308e-07 ko00240 Pyrimidine metabolism 19/323 110/7206 3.29256043174e-07 ko03410 Base excision repair 11/323 38/7206 5.02362434646e-07 ko04080 Neuroactive ligand-receptor interaction 2/323 423/7206 1.20518748012e-06 ko04141 Protein processing in endoplasmic reticulum 24/323 184/7206 2.03185980434e-06 ko03430 Mismatch repair 8/323 22/7206 2.75451275208e-06 ko03420 Nucleotide excision repair 11/323 46/7206 4.03386478185e-06 ko04111 Cell cycle - yeast 15/323 90/7206 9.21172628322e-06 ko03060 Protein export 7/323 23/7206 4.48543522309e-05 ko00230 Purine metabolism 22/323 194/7206 5.11142056814e-05 ko03015 mRNA surveillance pathway 13/323 93/7206 0.000234473534088 ko00510 N-Glycan biosynthesis 9/323 50/7206 0.000321553294467 ko04020 Calcium signaling pathway 2/323 265/7206 0.00072393616049 ko04113 Meiosis - yeast 10/323 70/7206 0.00102841284783 ko00670 One carbon pool by folate 5/323 20/7206 0.00155807326853 ko04115 p53 signaling pathway 10/323 74/7206 0.00158953096438 ko04261 Adrenergic signaling in cardiomyocytes 1/323 205/7206 0.0016137079003 ko04060 Cytokine-cytokine receptor interaction 1/323 191/7206 0.00230246880463 ko00513 Various types of N-glycan biosynthesis 7/323 42/7206 0.00237100813275 ko04550 Signaling pathways regulating pluripotency of stem cells 1/323 165/7206 0.00709254623463 ko05010 Alzheimer's disease 2/323 202/7206 0.00885390763658 ko03050 Proteasome 7/323 54/7206 0.00984481377955 ko01523 Antifolate resistance 5/323 30/7206 0.00992139240807 ko04270 Vascular smooth muscle contraction 1/323 154/7206 0.0156539590139 ko04728 Dopaminergic synapse 2/323 185/7206 0.0177809238659 ko04010 MAPK signaling pathway 6/323 321/7206 0.0179865818967 ko04022 cGMP-PKG signaling pathway 3/323 216/7206 0.0188463709994 ko05130 Pathogenic Escherichia coli infection 8/323 77/7206 0.0213495925354 ko04916 Melanogenesis 1/323 142/7206 0.0218468959137 ko04723 Retrograde endocannabinoid signaling 2/323 175/7206 0.0249193182116 ko04371 Apelin signaling pathway 2/323 177/7206 0.0251856478932 ko03450 Non-homologous end-joining 3/323 15/7206 0.0271825847689 ko03010 Ribosome 1/323 129/7206 0.0309900513907 ko04380 Osteoclast differentiation 1/323 134/7206 0.0317458247873 ko04068 FoxO signaling pathway 2/323 167/7206 0.0351275621282 ko03020 RNA polymerase 4/323 29/7206 0.038862184428 ko04668 TNF signaling pathway 1/323 120/7206 0.0445596026507 ko04750 Inflammatory mediator regulation of TRP channels 1/323 122/7206 0.0447384825406 ko00361 Chlorocyclohexane and chlorobenzene degradation 1/323 1/7206 0.0448237579796 ko00364 Fluorobenzoate degradation 1/323 1/7206 0.0448237579796 ko00623 Toluene degradation 1/323 1/7206 0.0448237579796 ko04066 HIF-1 signaling pathway 1/323 123/7206 0.0449512461737 ko05012 Parkinson's disease 2/323 155/7206 0.0486179484308 ko04725 Cholinergic synapse 2/323 160/7206 0.0497936260397