ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 123/875 423/7206 3.24136619845e-22 ko05032 Morphine addiction 51/875 110/7206 3.31756762936e-19 ko04724 Glutamatergic synapse 60/875 152/7206 3.9138163569e-18 ko05033 Nicotine addiction 34/875 56/7206 6.21701726748e-18 ko04024 cAMP signaling pathway 82/875 279/7206 2.74669881859e-15 ko04727 GABAergic synapse 45/875 110/7206 1.4311203247e-14 ko04713 Circadian entrainment 51/875 136/7206 1.63652843602e-14 ko04725 Cholinergic synapse 55/875 160/7206 1.08262568408e-13 ko04728 Dopaminergic synapse 60/875 185/7206 1.53577330342e-13 ko04721 Synaptic vesicle cycle 36/875 80/7206 2.01611532646e-13 ko04723 Retrograde endocannabinoid signaling 55/875 175/7206 6.83064839728e-12 ko04911 Insulin secretion 41/875 117/7206 7.99355182165e-11 ko04726 Serotonergic synapse 43/875 137/7206 1.49525777727e-09 ko04921 Oxytocin signaling pathway 57/875 209/7206 1.92649250538e-09 ko04744 Phototransduction 19/875 36/7206 3.768766906e-09 ko04261 Adrenergic signaling in cardiomyocytes 54/875 205/7206 2.33581392873e-08 ko04020 Calcium signaling pathway 64/875 265/7206 4.24272739594e-08 ko04070 Phosphatidylinositol signaling system 35/875 112/7206 5.77184540021e-08 ko05322 Systemic lupus erythematosus 2/875 151/7206 9.83716164755e-07 ko03040 Spliceosome 2/875 145/7206 2.17078673373e-06 ko05031 Amphetamine addiction 27/875 91/7206 5.73518921589e-06 ko03013 RNA transport 4/875 166/7206 1.00585904747e-05 ko04970 Salivary secretion 27/875 95/7206 1.80464256142e-05 ko04072 Phospholipase D signaling pathway 45/875 197/7206 1.97163129403e-05 ko04010 MAPK signaling pathway 65/875 321/7206 2.27524570894e-05 ko04022 cGMP-PKG signaling pathway 48/875 216/7206 2.8035864472e-05 ko04720 Long-term potentiation 27/875 99/7206 3.38572039652e-05 ko04742 Taste transduction 19/875 61/7206 6.62213319834e-05 ko04360 Axon guidance 49/875 233/7206 8.99181161504e-05 ko05030 Cocaine addiction 21/875 73/7206 0.000101847289126 ko04730 Long-term depression 22/875 78/7206 0.000135858740171 ko04120 Ubiquitin mediated proteolysis 4/875 138/7206 0.000183697050332 ko04710 Circadian rhythm 14/875 43/7206 0.000357935763726 ko04925 Aldosterone synthesis and secretion 26/875 105/7206 0.000386842293956 ko05203 Viral carcinogenesis 16/875 277/7206 0.000473826503935 ko04966 Collecting duct acid secretion 10/875 26/7206 0.000563435686039 ko04014 Ras signaling pathway 53/875 279/7206 0.000716204548576 ko00562 Inositol phosphate metabolism 22/875 89/7206 0.000869236962528 ko04110 Cell cycle 6/875 145/7206 0.00122322431518 ko04745 Phototransduction - fly 12/875 38/7206 0.0012672177731 ko04964 Proximal tubule bicarbonate reclamation 10/875 29/7206 0.00151140185535 ko04972 Pancreatic secretion 25/875 111/7206 0.0018272497096 ko04930 Type II diabetes mellitus 15/875 54/7206 0.00234266138808 ko04514 Cell adhesion molecules (CAMs) 28/875 130/7206 0.00248848427144 ko04960 Aldosterone-regulated sodium reabsorption 12/875 41/7206 0.00262061819476 ko04141 Protein processing in endoplasmic reticulum 10/875 184/7206 0.0028221700626 ko05231 Choline metabolism in cancer 28/875 134/7206 0.00316763859152 ko05168 Herpes simplex infection 10/875 182/7206 0.00378079099621 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/875 14/7206 0.00398860114129 ko04621 NOD-like receptor signaling pathway 8/875 157/7206 0.00418206221107 ko04971 Gastric acid secretion 22/875 98/7206 0.00432334001476 ko05169 Epstein-Barr virus infection 13/875 206/7206 0.00669143650318 ko04612 Antigen processing and presentation 2/875 77/7206 0.00725823332164 ko04260 Cardiac muscle contraction 21/875 98/7206 0.00768674778355 ko05230 Central carbon metabolism in cancer 18/875 81/7206 0.00934676938197 ko05110 Vibrio cholerae infection 15/875 63/7206 0.00990165610356 ko04064 NF-kappa B signaling pathway 4/875 96/7206 0.0113381740081 ko04923 Regulation of lipolysis in adipocytes 17/875 77/7206 0.0127275430216 ko04973 Carbohydrate digestion and absorption 11/875 42/7206 0.0139897816011 ko04711 Circadian rhythm - fly 5/875 13/7206 0.0145372138933 ko04626 Plant-pathogen interaction 6/875 18/7206 0.0161072144924 ko04666 Fc gamma R-mediated phagocytosis 24/875 122/7206 0.0164078860561 ko00280 Valine, leucine and isoleucine degradation 1/875 54/7206 0.0184856470276 ko05014 Amyotrophic lateral sclerosis (ALS) 16/875 74/7206 0.0186630572536 ko04071 Sphingolipid signaling pathway 30/875 162/7206 0.0198663670265 ko04915 Estrogen signaling pathway 25/875 131/7206 0.0207172273579 ko05164 Influenza A 11/875 167/7206 0.022625585454 ko04740 Olfactory transduction 17/875 80/7206 0.0230563003783 ko05133 Pertussis 4/875 87/7206 0.03009838642 ko05016 Huntington's disease 16/875 215/7206 0.033321612156 ko04750 Inflammatory mediator regulation of TRP channels 23/875 122/7206 0.0343853136946 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 16/875 79/7206 0.0358984699354 ko05214 Glioma 16/875 79/7206 0.0358984699354 ko03022 Basal transcription factors 1/875 44/7206 0.0373798909413 ko05144 Malaria 1/875 45/7206 0.0374527961341 ko03420 Nucleotide excision repair 1/875 46/7206 0.038108344314 ko04924 Renin secretion 17/875 86/7206 0.0437501993342 ko04722 Neurotrophin signaling pathway 28/875 160/7206 0.0488309472438 ko04152 AMPK signaling pathway 28/875 161/7206 0.0496885680534