ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	165/1026	423/7206	5.53644902996e-39
ko04724	Glutamatergic synapse	79/1026	152/7206	1.01706401003e-28
ko05033	Nicotine addiction	45/1026	56/7206	1.05979678064e-28
ko04721	Synaptic vesicle cycle	52/1026	80/7206	1.6110365852e-25
ko05032	Morphine addiction	58/1026	110/7206	9.4608119064e-22
ko04728	Dopaminergic synapse	78/1026	185/7206	5.44671118834e-21
ko04727	GABAergic synapse	57/1026	110/7206	6.5874873054e-21
ko04713	Circadian entrainment	61/1026	136/7206	3.04121178486e-18
ko04725	Cholinergic synapse	65/1026	160/7206	1.1191757555e-16
ko04723	Retrograde endocannabinoid signaling	68/1026	175/7206	3.34157447605e-16
ko04742	Taste transduction	35/1026	61/7206	4.05854268052e-15
ko04024	cAMP signaling pathway	89/1026	279/7206	1.49831932308e-14
ko04726	Serotonergic synapse	52/1026	137/7206	3.32910114016e-12
ko04911	Insulin secretion	46/1026	117/7206	1.45023118569e-11
ko05031	Amphetamine addiction	37/1026	91/7206	4.76171273024e-10
ko04744	Phototransduction	21/1026	36/7206	9.10401774529e-10
ko04720	Long-term potentiation	37/1026	99/7206	7.60588013832e-09
ko03040	Spliceosome	1/1026	145/7206	9.36617219404e-09
ko04921	Oxytocin signaling pathway	61/1026	209/7206	1.48099830703e-08
ko05030	Cocaine addiction	30/1026	73/7206	1.58122532132e-08
ko04261	Adrenergic signaling in cardiomyocytes	58/1026	205/7206	1.23965583921e-07
ko04020	Calcium signaling pathway	70/1026	265/7206	1.27148255516e-07
ko04360	Axon guidance	63/1026	233/7206	1.77250016436e-07
ko05203	Viral carcinogenesis	14/1026	277/7206	1.03301941489e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1026	74/7206	1.41505968537e-06
ko05168	Herpes simplex infection	6/1026	182/7206	1.42030049108e-06
ko05164	Influenza A	5/1026	167/7206	1.6079197952e-06
ko03013	RNA transport	5/1026	166/7206	1.61215260292e-06
ko04060	Cytokine-cytokine receptor interaction	7/1026	191/7206	1.66444317908e-06
ko04120	Ubiquitin mediated proteolysis	3/1026	138/7206	1.83703926062e-06
ko04621	NOD-like receptor signaling pathway	5/1026	157/7206	7.44901434884e-06
ko04966	Collecting duct acid secretion	13/1026	26/7206	1.56959802481e-05
ko04010	MAPK signaling pathway	73/1026	321/7206	2.6954594578e-05
ko04260	Cardiac muscle contraction	30/1026	98/7206	2.70173229855e-05
ko04740	Olfactory transduction	26/1026	80/7206	2.89208246322e-05
ko04970	Salivary secretion	29/1026	95/7206	3.9556821629e-05
ko04514	Cell adhesion molecules (CAMs)	36/1026	130/7206	6.07469037084e-05
ko04141	Protein processing in endoplasmic reticulum	9/1026	184/7206	6.26160780064e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1026	79/7206	6.30343936252e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1026	79/7206	0.000129481046718
ko05322	Systemic lupus erythematosus	7/1026	151/7206	0.000217700113432
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1026	14/7206	0.000222090068331
ko04924	Renin secretion	25/1026	86/7206	0.000290226203302
ko04925	Aldosterone synthesis and secretion	29/1026	105/7206	0.000329080547775
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1026	59/7206	0.000453713178009
ko04540	Gap junction	33/1026	128/7206	0.000480981544406
ko05162	Measles	5/1026	120/7206	0.00052114093124
ko04064	NF-kappa B signaling pathway	3/1026	96/7206	0.000571467934383
ko04915	Estrogen signaling pathway	33/1026	131/7206	0.000874671425423
ko05169	Epstein-Barr virus infection	14/1026	206/7206	0.00111853848373
ko04971	Gastric acid secretion	26/1026	98/7206	0.00117376386118
ko05205	Proteoglycans in cancer	21/1026	271/7206	0.00132975587781
ko05140	Leishmaniasis	2/1026	75/7206	0.00138424226243
ko04022	cGMP-PKG signaling pathway	48/1026	216/7206	0.00143076661602
ko00240	Pyrimidine metabolism	5/1026	110/7206	0.00145415843311
ko00330	Arginine and proline metabolism	1/1026	61/7206	0.00146714987656
ko04730	Long-term depression	22/1026	78/7206	0.00152816998431
ko04014	Ras signaling pathway	58/1026	279/7206	0.00216672187135
ko03018	RNA degradation	3/1026	84/7206	0.00245025969374
ko05145	Toxoplasmosis	7/1026	126/7206	0.00287297076027
ko01200	Carbon metabolism	7/1026	128/7206	0.00297394011214
ko05110	Vibrio cholerae infection	18/1026	63/7206	0.00298446075045
ko00480	Glutathione metabolism	1/1026	55/7206	0.00328193557646
ko04110	Cell cycle	9/1026	145/7206	0.00365389901916
ko04972	Pancreatic secretion	27/1026	111/7206	0.00383285050827
ko00590	Arachidonic acid metabolism	1/1026	52/7206	0.00490113549261
ko04964	Proximal tubule bicarbonate reclamation	10/1026	29/7206	0.00501245290598
ko04146	Peroxisome	4/1026	89/7206	0.00540161216438
ko05414	Dilated cardiomyopathy	27/1026	112/7206	0.00578767836715
ko04640	Hematopoietic cell lineage	2/1026	64/7206	0.00628460862108
ko04976	Bile secretion	20/1026	80/7206	0.00934050177781
ko04072	Phospholipase D signaling pathway	41/1026	197/7206	0.00966560119663
ko00310	Lysine degradation	3/1026	73/7206	0.0103450718258
ko05034	Alcoholism	48/1026	238/7206	0.0106023090004
ko04217	Necroptosis	14/1026	178/7206	0.0120974952078
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1026	15/7206	0.0130316837122
ko04371	Apelin signaling pathway	37/1026	177/7206	0.0159330255975
ko03022	Basal transcription factors	1/1026	44/7206	0.0160878289746
ko05144	Malaria	1/1026	45/7206	0.0163918088238
ko00071	Fatty acid degradation	1/1026	45/7206	0.0163918088238
ko04745	Phototransduction - fly	11/1026	38/7206	0.0169856211715
ko00620	Pyruvate metabolism	1/1026	46/7206	0.0170996508145
ko03420	Nucleotide excision repair	1/1026	46/7206	0.0170996508145
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1026	182/7206	0.0176654071707
ko04930	Type II diabetes mellitus	14/1026	54/7206	0.0189361640581
ko05146	Amoebiasis	6/1026	99/7206	0.0192459176568
ko05321	Inflammatory bowel disease (IBD)	2/1026	56/7206	0.0192998916013
ko04070	Phosphatidylinositol signaling system	25/1026	112/7206	0.0196104422892
ko05161	Hepatitis B	14/1026	173/7206	0.020033796478
ko04612	Antigen processing and presentation	4/1026	77/7206	0.0204146192949
ko04391	Hippo signaling pathway - fly	21/1026	90/7206	0.0212976097341
ko00140	Steroid hormone biosynthesis	1/1026	41/7206	0.0238235445063
ko00983	Drug metabolism - other enzymes	1/1026	42/7206	0.0242068595168
ko04622	RIG-I-like receptor signaling pathway	3/1026	62/7206	0.0282530474186
ko00561	Glycerolipid metabolism	3/1026	63/7206	0.0283754836776
ko00600	Sphingolipid metabolism	3/1026	63/7206	0.0283754836776
ko00280	Valine, leucine and isoleucine degradation	2/1026	54/7206	0.0286286802179
ko05410	Hypertrophic cardiomyopathy (HCM)	22/1026	100/7206	0.0304554174358
ko04668	TNF signaling pathway	9/1026	120/7206	0.0340832553875
ko05418	Fluid shear stress and atherosclerosis	15/1026	173/7206	0.0356741058843
ko04138	Autophagy - yeast	5/1026	81/7206	0.0364816313203
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1026	40/7206	0.0369637673588
ko00380	Tryptophan metabolism	2/1026	50/7206	0.0395923224529
ko04214	Apoptosis - fly	4/1026	72/7206	0.0396093949647
ko04973	Carbohydrate digestion and absorption	11/1026	42/7206	0.041887766221
ko04657	IL-17 signaling pathway	6/1026	87/7206	0.0452566933927
ko05133	Pertussis	6/1026	87/7206	0.0452566933927
ko05166	HTLV-I infection	30/1026	292/7206	0.0490420643492
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/1026	92/7206	0.0493186161149