ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	124/748	423/7206	2.57055727237e-29
ko04724	Glutamatergic synapse	66/748	152/7206	1.59968592763e-26
ko05033	Nicotine addiction	39/748	56/7206	3.02674303322e-26
ko04727	GABAergic synapse	48/748	110/7206	1.16612770111e-19
ko05032	Morphine addiction	47/748	110/7206	8.15688504655e-19
ko04728	Dopaminergic synapse	63/748	185/7206	1.01259807289e-18
ko04721	Synaptic vesicle cycle	38/748	80/7206	2.38804732474e-17
ko04713	Circadian entrainment	49/748	136/7206	6.39675194204e-16
ko04723	Retrograde endocannabinoid signaling	55/748	175/7206	9.43119594632e-15
ko04725	Cholinergic synapse	50/748	160/7206	2.08926555318e-13
ko04024	cAMP signaling pathway	66/748	279/7206	6.69806421094e-11
ko04911	Insulin secretion	37/748	117/7206	2.07294176635e-10
ko04726	Serotonergic synapse	39/748	137/7206	2.11932214718e-09
ko04360	Axon guidance	53/748	233/7206	2.09810203457e-08
ko05030	Cocaine addiction	25/748	73/7206	3.11035207773e-08
ko05031	Amphetamine addiction	27/748	91/7206	2.5972631853e-07
ko04261	Adrenergic signaling in cardiomyocytes	46/748	205/7206	2.97589995365e-07
ko04742	Taste transduction	21/748	61/7206	3.59131069592e-07
ko04010	MAPK signaling pathway	62/748	321/7206	8.32408845963e-07
ko04060	Cytokine-cytokine receptor interaction	3/748	191/7206	2.85628224943e-06
ko03040	Spliceosome	1/748	145/7206	3.11986744861e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	22/748	74/7206	3.21963184233e-06
ko04514	Cell adhesion molecules (CAMs)	31/748	130/7206	6.94033996784e-06
ko04921	Oxytocin signaling pathway	43/748	209/7206	8.62093924015e-06
ko05203	Viral carcinogenesis	9/748	277/7206	1.18928493259e-05
ko05164	Influenza A	3/748	167/7206	2.7042089617e-05
ko04744	Phototransduction	13/748	36/7206	3.4923679605e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/748	79/7206	3.57974076628e-05
ko04120	Ubiquitin mediated proteolysis	2/748	138/7206	5.7648507232e-05
ko04720	Long-term potentiation	24/748	99/7206	7.06013246358e-05
ko04730	Long-term depression	20/748	78/7206	9.50013443239e-05
ko03013	RNA transport	4/748	166/7206	0.000146575759504
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/748	14/7206	0.000225143814668
ko04970	Salivary secretion	22/748	95/7206	0.000246786889051
ko04621	NOD-like receptor signaling pathway	4/748	157/7206	0.000293739894917
ko04020	Calcium signaling pathway	46/748	265/7206	0.000426528560101
ko05168	Herpes simplex infection	6/748	182/7206	0.000505552326978
ko05322	Systemic lupus erythematosus	4/748	151/7206	0.000607867080859
ko05169	Epstein-Barr virus infection	8/748	206/7206	0.00102795794448
ko04260	Cardiac muscle contraction	21/748	98/7206	0.0011594358988
ko04146	Peroxisome	1/748	89/7206	0.00125664549532
ko04141	Protein processing in endoplasmic reticulum	7/748	184/7206	0.00136169620222
ko04350	TGF-beta signaling pathway	2/748	103/7206	0.00171080621448
ko04932	Non-alcoholic fatty liver disease (NAFLD)	7/748	182/7206	0.00187495841056
ko04972	Pancreatic secretion	22/748	111/7206	0.00250088610259
ko04014	Ras signaling pathway	45/748	279/7206	0.00250185318099
ko03008	Ribosome biogenesis in eukaryotes	1/748	79/7206	0.00267634040574
ko05205	Proteoglycans in cancer	14/748	271/7206	0.00302913782169
ko04915	Estrogen signaling pathway	24/748	131/7206	0.00539998109452
ko04217	Necroptosis	8/748	178/7206	0.00597973727492
ko05162	Measles	4/748	120/7206	0.00629337303724
ko04022	cGMP-PKG signaling pathway	35/748	216/7206	0.00644141469184
ko04971	Gastric acid secretion	19/748	98/7206	0.00671004647966
ko04924	Renin secretion	17/748	86/7206	0.00731196086013
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/748	59/7206	0.00797392221544
ko04110	Cell cycle	6/748	145/7206	0.00868212803014
ko03018	RNA degradation	2/748	84/7206	0.0106341717241
ko04930	Type II diabetes mellitus	12/748	54/7206	0.0107587643238
ko05146	Amoebiasis	3/748	99/7206	0.0117505806291
ko01200	Carbon metabolism	5/748	128/7206	0.0121270886431
ko04640	Hematopoietic cell lineage	1/748	64/7206	0.0125225591842
ko04966	Collecting duct acid secretion	7/748	26/7206	0.014244322461
ko04925	Aldosterone synthesis and secretion	19/748	105/7206	0.0145318102569
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/748	15/7206	0.0147196146856
ko04064	NF-kappa B signaling pathway	3/748	96/7206	0.0167335696549
ko00240	Pyrimidine metabolism	4/748	110/7206	0.0168641051175
ko04072	Phospholipase D signaling pathway	31/748	197/7206	0.0172682699377
ko05414	Dilated cardiomyopathy	20/748	112/7206	0.0175862686476
ko00330	Arginine and proline metabolism	1/748	61/7206	0.018499922248
ko05140	Leishmaniasis	2/748	75/7206	0.0214612345424
ko05034	Alcoholism	36/748	238/7206	0.0224574746704
ko04964	Proximal tubule bicarbonate reclamation	7/748	29/7206	0.0257272424224
ko05321	Inflammatory bowel disease (IBD)	1/748	56/7206	0.0268172765558
ko04214	Apoptosis - fly	2/748	72/7206	0.0307080009014
ko05016	Huntington's disease	13/748	215/7206	0.0310199634294
ko00310	Lysine degradation	2/748	73/7206	0.0312126265104
ko04015	Rap1 signaling pathway	40/748	278/7206	0.0344243531712
ko04140	Autophagy - animal	9/748	164/7206	0.0374471680738
ko05145	Toxoplasmosis	6/748	126/7206	0.0377551277736
ko04540	Gap junction	21/748	128/7206	0.0387550801441
ko00515	Mannose type O-glycan biosynthesis	6/748	25/7206	0.0388835967352
ko00590	Arachidonic acid metabolism	1/748	52/7206	0.0391282105204
ko00480	Glutathione metabolism	1/748	55/7206	0.0412383850227
ko00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/748	8/7206	0.0418749205969
ko04740	Olfactory transduction	14/748	80/7206	0.0424036483927
ko05161	Hepatitis B	10/748	173/7206	0.0431998312597
ko00564	Glycerophospholipid metabolism	4/748	99/7206	0.0439141925075
ko05410	Hypertrophic cardiomyopathy (HCM)	17/748	100/7206	0.0449107304597
ko05166	HTLV-I infection	20/748	292/7206	0.0492984071543