ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 27/301 134/7206 4.85815832081e-12 ko04621 NOD-like receptor signaling pathway 29/301 157/7206 7.49194372151e-12 ko04668 TNF signaling pathway 25/301 120/7206 1.43382554548e-11 ko05164 Influenza A 26/301 167/7206 4.56457473271e-09 ko04060 Cytokine-cytokine receptor interaction 27/301 191/7206 1.94052017549e-08 ko04623 Cytosolic DNA-sensing pathway 12/301 41/7206 6.03091888314e-08 ko04064 NF-kappa B signaling pathway 18/301 96/7206 6.41938144077e-08 ko04620 Toll-like receptor signaling pathway 18/301 100/7206 1.23608721321e-07 ko05161 Hepatitis B 23/301 173/7206 7.02371197455e-07 ko04622 RIG-I-like receptor signaling pathway 13/301 62/7206 1.1935425127e-06 ko04657 IL-17 signaling pathway 15/301 87/7206 2.50746463243e-06 ko05133 Pertussis 15/301 87/7206 2.50746463243e-06 ko00643 Styrene degradation 4/301 4/7206 2.98648158276e-06 ko04210 Apoptosis 21/301 180/7206 1.74210504077e-05 ko05168 Herpes simplex infection 21/301 182/7206 2.06454405061e-05 ko05152 Tuberculosis 21/301 187/7206 3.1178118017e-05 ko04630 Jak-STAT signaling pathway 17/301 132/7206 3.13723196303e-05 ko05134 Legionellosis 12/301 74/7206 4.85129107534e-05 ko04660 T cell receptor signaling pathway 16/301 124/7206 5.24247144246e-05 ko04662 B cell receptor signaling pathway 13/301 88/7206 6.48183768159e-05 ko05323 Rheumatoid arthritis 13/301 89/7206 7.31072952254e-05 ko05144 Malaria 9/301 45/7206 8.06255065519e-05 ko05142 Chagas disease (American trypanosomiasis) 16/301 130/7206 9.34181725951e-05 ko04610 Complement and coagulation cascades 12/301 79/7206 9.3888192869e-05 ko04672 Intestinal immune network for IgA production 8/301 37/7206 0.000112959584431 ko05162 Measles 15/301 120/7206 0.000129434822109 ko04932 Non-alcoholic fatty liver disease (NAFLD) 19/301 182/7206 0.000198181498778 ko05145 Toxoplasmosis 15/301 126/7206 0.000224522967656 ko00140 Steroid hormone biosynthesis 8/301 41/7206 0.000241673738374 ko00350 Tyrosine metabolism 7/301 33/7206 0.00034611169977 ko04217 Necroptosis 18/301 178/7206 0.000430801034258 ko05321 Inflammatory bowel disease (IBD) 9/301 56/7206 0.000460244016416 ko05150 Staphylococcus aureus infection 7/301 36/7206 0.000607318304767 ko05132 Salmonella infection 12/301 98/7206 0.000732686493382 ko05140 Leishmaniasis 10/301 75/7206 0.00103535904646 ko00120 Primary bile acid biosynthesis 5/301 20/7206 0.00113592659326 ko00980 Metabolism of xenobiotics by cytochrome P450 7/301 40/7206 0.00117545722913 ko05167 Kaposi's sarcoma-associated herpesvirus infection 18/301 191/7206 0.00125537701123 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/301 135/7206 0.00144903450426 ko04666 Fc gamma R-mediated phagocytosis 13/301 122/7206 0.00165980925897 ko00660 C5-Branched dibasic acid metabolism 2/301 2/7206 0.00173923996949 ko05146 Amoebiasis 11/301 99/7206 0.00266993852619 ko04659 Th17 cell differentiation 11/301 106/7206 0.00454896310181 ko00360 Phenylalanine metabolism 4/301 17/7206 0.00461202802783 ko04080 Neuroactive ligand-receptor interaction 7/301 423/7206 0.00537859238854 ko05160 Hepatitis C 14/301 153/7206 0.0060013385988 ko05166 HTLV-I infection 22/301 292/7206 0.00657985037106 ko05131 Shigellosis 9/301 82/7206 0.00690363720032 ko05340 Primary immunodeficiency 5/301 30/7206 0.00741793294634 ko04728 Dopaminergic synapse 1/301 185/7206 0.00758225168152 ko05210 Colorectal cancer 9/301 86/7206 0.00937356981299 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/301 4/7206 0.00986690592367 ko04920 Adipocytokine signaling pathway 9/301 89/7206 0.0116260548183 ko05204 Chemical carcinogenesis 6/301 48/7206 0.0141548202276 ko04624 Toll and Imd signaling pathway 6/301 49/7206 0.0155815691716 ko00281 Geraniol degradation 2/301 5/7206 0.0159929709413 ko05418 Fluid shear stress and atherosclerosis 14/301 173/7206 0.0181998248331 ko04658 Th1 and Th2 cell differentiation 9/301 96/7206 0.0184297908151 ko04650 Natural killer cell mediated cytotoxicity 9/301 97/7206 0.0195975444296 ko04218 Cellular senescence 14/301 177/7206 0.0201665976245 ko00040 Pentose and glucuronate interconversions 4/301 26/7206 0.021577617776 ko04724 Glutamatergic synapse 1/301 152/7206 0.0219009384905 ko00362 Benzoate degradation 2/301 6/7206 0.0233325940402 ko05416 Viral myocarditis 6/301 55/7206 0.0262668383845 ko00830 Retinol metabolism 5/301 42/7206 0.0295323005162 ko04931 Insulin resistance 11/301 137/7206 0.03058160569 ko04916 Melanogenesis 1/301 142/7206 0.0314781124742 ko05169 Epstein-Barr virus infection 15/301 206/7206 0.0323253530894 ko04115 p53 signaling pathway 7/301 74/7206 0.0341417437721 ko01524 Platinum drug resistance 7/301 76/7206 0.0386856729343 ko00401 Novobiocin biosynthesis 1/301 1/7206 0.0417707466 ko05143 African trypanosomiasis 4/301 32/7206 0.0427468904342 ko03010 Ribosome 1/301 129/7206 0.0447671154483 ko04215 Apoptosis - multiple species 5/301 47/7206 0.0450630947582 ko04611 Platelet activation 12/301 163/7206 0.0470459683597 ko04726 Serotonergic synapse 1/301 137/7206 0.0472263963785