ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	37/477	56/7206	8.07943677121e-31
ko04724	Glutamatergic synapse	57/477	152/7206	2.49701496743e-29
ko04080	Neuroactive ligand-receptor interaction	94/477	423/7206	1.34756869798e-27
ko04727	GABAergic synapse	39/477	110/7206	2.65612051226e-19
ko04728	Dopaminergic synapse	49/477	185/7206	7.1760330356e-18
ko04723	Retrograde endocannabinoid signaling	47/477	175/7206	1.92853768315e-17
ko05032	Morphine addiction	36/477	110/7206	1.32007057142e-16
ko04713	Circadian entrainment	38/477	136/7206	6.55050929538e-15
ko04721	Synaptic vesicle cycle	28/477	80/7206	5.12963105855e-14
ko05031	Amphetamine addiction	27/477	91/7206	1.29700086229e-11
ko05030	Cocaine addiction	24/477	73/7206	1.60137266957e-11
ko04024	cAMP signaling pathway	49/477	279/7206	1.50378874158e-10
ko04720	Long-term potentiation	25/477	99/7206	3.2524121806e-09
ko04911	Insulin secretion	26/477	117/7206	2.83459606904e-08
ko04725	Cholinergic synapse	31/477	160/7206	4.06868439309e-08
ko04726	Serotonergic synapse	28/477	137/7206	5.69124542006e-08
ko04020	Calcium signaling pathway	41/477	265/7206	2.20945821788e-07
ko04742	Taste transduction	17/477	61/7206	2.38751342878e-07
ko04010	MAPK signaling pathway	46/477	321/7206	4.31578047096e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	18/477	74/7206	9.76611951049e-07
ko04514	Cell adhesion molecules (CAMs)	25/477	130/7206	9.93019621367e-07
ko04261	Adrenergic signaling in cardiomyocytes	32/477	205/7206	4.59076227558e-06
ko04730	Long-term depression	16/477	78/7206	3.946620478e-05
ko04921	Oxytocin signaling pathway	30/477	209/7206	4.99949181212e-05
ko05203	Viral carcinogenesis	4/477	277/7206	6.20109389367e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	15/477	79/7206	0.000172348026305
ko04970	Salivary secretion	16/477	95/7206	0.000444942315645
ko04260	Cardiac muscle contraction	16/477	98/7206	0.000635667545013
ko04915	Estrogen signaling pathway	19/477	131/7206	0.00105235195325
ko05034	Alcoholism	29/477	238/7206	0.0012645616009
ko05164	Influenza A	2/477	167/7206	0.00140828894333
ko04072	Phospholipase D signaling pathway	24/477	197/7206	0.00327572183506
ko05205	Proteoglycans in cancer	7/477	271/7206	0.00388770985552
ko05169	Epstein-Barr virus infection	4/477	206/7206	0.00389587704371
ko04014	Ras signaling pathway	31/477	279/7206	0.00432187455152
ko04022	cGMP-PKG signaling pathway	25/477	216/7206	0.00522146774463
ko04110	Cell cycle	2/477	145/7206	0.00602471478709
ko04972	Pancreatic secretion	15/477	111/7206	0.0066355081752
ko03013	RNA transport	3/477	166/7206	0.006721036071
ko04930	Type II diabetes mellitus	9/477	54/7206	0.00831454737276
ko05168	Herpes simplex infection	4/477	182/7206	0.00982288992538
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/477	182/7206	0.00982288992538
ko04360	Axon guidance	26/477	233/7206	0.0100622013553
ko04630	Jak-STAT signaling pathway	2/477	132/7206	0.0120658800515
ko04924	Renin secretion	12/477	86/7206	0.0132851815119
ko04621	NOD-like receptor signaling pathway	3/477	157/7206	0.0134725475306
ko05146	Amoebiasis	1/477	99/7206	0.0141428971683
ko04940	Type I diabetes mellitus	6/477	32/7206	0.0169103140219
ko05414	Dilated cardiomyopathy	14/477	112/7206	0.0194273580869
ko05231	Choline metabolism in cancer	16/477	134/7206	0.0205939460795
ko05410	Hypertrophic cardiomyopathy (HCM)	13/477	100/7206	0.0224595890777
ko05162	Measles	2/477	120/7206	0.0241835836944
ko04966	Collecting duct acid secretion	5/477	26/7206	0.0257134602801
ko04925	Aldosterone synthesis and secretion	13/477	105/7206	0.0267631394309
ko04744	Phototransduction	6/477	36/7206	0.0291060131331
ko04146	Peroxisome	1/477	89/7206	0.0298053990091
ko04217	Necroptosis	5/477	178/7206	0.0326009672301
ko00240	Pyrimidine metabolism	2/477	110/7206	0.033467914184
ko04150	mTOR signaling pathway	5/477	184/7206	0.0335318750668
ko04141	Protein processing in endoplasmic reticulum	5/477	184/7206	0.0335318750668
ko04120	Ubiquitin mediated proteolysis	3/477	138/7206	0.0354826512945
ko04971	Gastric acid secretion	12/477	98/7206	0.0369807092623
ko04964	Proximal tubule bicarbonate reclamation	5/477	29/7206	0.0394854480551
ko04740	Olfactory transduction	10/477	80/7206	0.0413997571629
ko05010	Alzheimer's disease	21/477	202/7206	0.0424444621359
ko03018	RNA degradation	1/477	84/7206	0.0434776469442
ko05322	Systemic lupus erythematosus	4/477	151/7206	0.0459864585824
ko01200	Carbon metabolism	3/477	128/7206	0.047401573305