ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1260	423/7206	9.97552094483e-51
ko04724	Glutamatergic synapse	90/1260	152/7206	2.09014117666e-31
ko05033	Nicotine addiction	47/1260	56/7206	1.83665276152e-27
ko05032	Morphine addiction	69/1260	110/7206	1.99220654763e-26
ko04727	GABAergic synapse	68/1260	110/7206	1.63005640323e-25
ko04713	Circadian entrainment	75/1260	136/7206	1.2449274891e-23
ko04725	Cholinergic synapse	79/1260	160/7206	8.26412383187e-21
ko04728	Dopaminergic synapse	86/1260	185/7206	2.33560428389e-20
ko04721	Synaptic vesicle cycle	51/1260	80/7206	2.76422468173e-20
ko04723	Retrograde endocannabinoid signaling	79/1260	175/7206	7.69555572627e-18
ko04024	cAMP signaling pathway	108/1260	279/7206	9.04226828283e-18
ko04020	Calcium signaling pathway	102/1260	265/7206	1.24736259418e-16
ko04726	Serotonergic synapse	65/1260	137/7206	3.28840997026e-16
ko04911	Insulin secretion	55/1260	117/7206	1.07877618172e-13
ko04921	Oxytocin signaling pathway	81/1260	209/7206	1.49775354055e-13
ko04742	Taste transduction	36/1260	61/7206	3.37266387508e-13
ko04744	Phototransduction	25/1260	36/7206	7.88740500641e-12
ko05031	Amphetamine addiction	43/1260	91/7206	4.40662050328e-11
ko04970	Salivary secretion	44/1260	95/7206	6.03517411675e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1260	205/7206	2.68489631974e-10
ko03010	Ribosome	1/1260	129/7206	5.70301793998e-10
ko03040	Spliceosome	2/1260	145/7206	5.98324274143e-10
ko04720	Long-term potentiation	43/1260	99/7206	1.24226025275e-09
ko05168	Herpes simplex infection	7/1260	182/7206	2.67726775569e-08
ko04740	Olfactory transduction	35/1260	80/7206	3.46635923466e-08
ko05322	Systemic lupus erythematosus	5/1260	151/7206	1.04692999044e-07
ko04925	Aldosterone synthesis and secretion	41/1260	105/7206	1.52731652553e-07
ko03013	RNA transport	7/1260	166/7206	2.52948024467e-07
ko05203	Viral carcinogenesis	19/1260	277/7206	2.68112281288e-07
ko04022	cGMP-PKG signaling pathway	67/1260	216/7206	9.9406781543e-07
ko04070	Phosphatidylinositol signaling system	41/1260	112/7206	1.02200591688e-06
ko04971	Gastric acid secretion	37/1260	98/7206	1.41903703515e-06
ko05030	Cocaine addiction	30/1260	73/7206	2.41666405048e-06
ko04060	Cytokine-cytokine receptor interaction	11/1260	191/7206	2.50966036205e-06
ko04966	Collecting duct acid secretion	15/1260	26/7206	4.52021903662e-06
ko04110	Cell cycle	7/1260	145/7206	7.00763111577e-06
ko04514	Cell adhesion molecules (CAMs)	43/1260	130/7206	1.22983603631e-05
ko04072	Phospholipase D signaling pathway	59/1260	197/7206	1.45910048316e-05
ko04141	Protein processing in endoplasmic reticulum	12/1260	184/7206	1.85823585189e-05
ko04730	Long-term depression	29/1260	78/7206	3.01866483219e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1260	74/7206	3.41313773196e-05
ko04924	Renin secretion	31/1260	86/7206	3.84527772159e-05
ko04972	Pancreatic secretion	37/1260	111/7206	4.23982949107e-05
ko05164	Influenza A	11/1260	167/7206	4.86163270207e-05
ko04540	Gap junction	41/1260	128/7206	5.07979505199e-05
ko04621	NOD-like receptor signaling pathway	10/1260	157/7206	6.81920896991e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1260	79/7206	7.03988973313e-05
ko04745	Phototransduction - fly	17/1260	38/7206	8.50337831596e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1260	122/7206	9.12158131104e-05
ko04612	Antigen processing and presentation	2/1260	77/7206	0.000107283623479
ko04064	NF-kappa B signaling pathway	4/1260	96/7206	0.000120438988445
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1260	79/7206	0.000130182051599
ko05414	Dilated cardiomyopathy	36/1260	112/7206	0.00013505910539
ko04014	Ras signaling pathway	74/1260	279/7206	0.000142269605587
ko04976	Bile secretion	28/1260	80/7206	0.000150986480696
ko05140	Leishmaniasis	2/1260	75/7206	0.000164186779115
ko05169	Epstein-Barr virus infection	17/1260	206/7206	0.000177023046639
ko04360	Axon guidance	63/1260	233/7206	0.000211582953972
ko05166	HTLV-I infection	29/1260	292/7206	0.0002815060323
ko05110	Vibrio cholerae infection	23/1260	63/7206	0.00030898442717
ko04610	Complement and coagulation cascades	3/1260	79/7206	0.000465513588094
ko00520	Amino sugar and nucleotide sugar metabolism	1/1260	55/7206	0.000523670605145
ko05205	Proteoglycans in cancer	27/1260	271/7206	0.000578236275169
ko04371	Apelin signaling pathway	49/1260	177/7206	0.000607233982142
ko04120	Ubiquitin mediated proteolysis	10/1260	138/7206	0.000632980685286
ko04010	MAPK signaling pathway	80/1260	321/7206	0.000676516587767
ko05162	Measles	8/1260	120/7206	0.0009254322731
ko05161	Hepatitis B	15/1260	173/7206	0.00113149014071
ko04330	Notch signaling pathway	2/1260	62/7206	0.00114011940396
ko04260	Cardiac muscle contraction	30/1260	98/7206	0.00119899869941
ko04923	Regulation of lipolysis in adipocytes	25/1260	77/7206	0.00128109195251
ko04922	Glucagon signaling pathway	37/1260	128/7206	0.00135360416912
ko04626	Plant-pathogen interaction	9/1260	18/7206	0.00158895269652
ko04964	Proximal tubule bicarbonate reclamation	12/1260	29/7206	0.00215273946579
ko04915	Estrogen signaling pathway	37/1260	131/7206	0.00229964923341
ko04657	IL-17 signaling pathway	5/1260	87/7206	0.00247094381365
ko05144	Malaria	1/1260	45/7206	0.00276141663024
ko03420	Nucleotide excision repair	1/1260	46/7206	0.00279095035985
ko05145	Toxoplasmosis	10/1260	126/7206	0.00290340453819
ko05321	Inflammatory bowel disease (IBD)	2/1260	56/7206	0.00386534917053
ko03022	Basal transcription factors	1/1260	44/7206	0.00427910547452
ko04214	Apoptosis - fly	4/1260	72/7206	0.00457859419614
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1260	100/7206	0.00484960004998
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1260	59/7206	0.00528214949666
ko04350	TGF-beta signaling pathway	8/1260	103/7206	0.00596949139289
ko04622	RIG-I-like receptor signaling pathway	3/1260	62/7206	0.0062945169501
ko04658	Th1 and Th2 cell differentiation	7/1260	96/7206	0.00631600817066
ko05133	Pertussis	6/1260	87/7206	0.00650191592457
ko04217	Necroptosis	18/1260	178/7206	0.00685995285248
ko00562	Inositol phosphate metabolism	26/1260	89/7206	0.00691417991318
ko04710	Circadian rhythm	15/1260	43/7206	0.00714468685813
ko00240	Pyrimidine metabolism	9/1260	110/7206	0.00752692283716
ko03018	RNA degradation	6/1260	84/7206	0.00892521079606
ko04510	Focal adhesion	27/1260	240/7206	0.00925953385798
ko05217	Basal cell carcinoma	4/1260	68/7206	0.00931582118205
ko00630	Glyoxylate and dicarboxylate metabolism	1/1260	38/7206	0.00946217586107
ko05231	Choline metabolism in cancer	35/1260	134/7206	0.0111589442121
ko05219	Bladder cancer	2/1260	48/7206	0.0117395420961
ko05131	Shigellosis	6/1260	82/7206	0.0122749697936
ko04115	p53 signaling pathway	5/1260	74/7206	0.0128686272377
ko05206	MicroRNAs in cancer	19/1260	177/7206	0.0158253124913
ko04146	Peroxisome	7/1260	89/7206	0.0159859349252
ko05222	Small cell lung cancer	7/1260	89/7206	0.0159859349252
ko00290	Valine, leucine and isoleucine biosynthesis	3/1260	4/7206	0.0185486891321
ko05200	Pathways in cancer	67/1260	492/7206	0.0193385102742
ko05202	Transcriptional misregulation in cancer	21/1260	188/7206	0.0193452746115
ko00010	Glycolysis / Gluconeogenesis	21/1260	74/7206	0.0198224798297
ko04630	Jak-STAT signaling pathway	13/1260	132/7206	0.0200402331189
ko04210	Apoptosis	20/1260	180/7206	0.0219307129079
ko04270	Vascular smooth muscle contraction	38/1260	154/7206	0.0236877240621
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1260	14/7206	0.0237498219313
ko04152	AMPK signaling pathway	39/1260	161/7206	0.027260867103
ko04659	Th17 cell differentiation	10/1260	106/7206	0.027801577361
ko04930	Type II diabetes mellitus	16/1260	54/7206	0.0287465429205
ko04912	GnRH signaling pathway	31/1260	122/7206	0.0294895467517
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1260	182/7206	0.0298271299921
ko04973	Carbohydrate digestion and absorption	13/1260	42/7206	0.0381638918399
ko04142	Lysosome	17/1260	151/7206	0.0398311965286
ko05418	Fluid shear stress and atherosclerosis	20/1260	173/7206	0.0420490798903
ko00230	Purine metabolism	45/1260	194/7206	0.0435262215132
ko00564	Glycerophospholipid metabolism	25/1260	99/7206	0.0456117944829
ko04620	Toll-like receptor signaling pathway	10/1260	100/7206	0.0466761512064
ko04810	Regulation of actin cytoskeleton	34/1260	264/7206	0.0472553501141
ko00280	Valine, leucine and isoleucine degradation	4/1260	54/7206	0.0483320476674
ko00480	Glutathione metabolism	4/1260	55/7206	0.0485124854313