ko pathway ratio_in_study ratio_in_pop p_value ko04744 Phototransduction 24/516 36/7206 1.10308423607e-19 ko05033 Nicotine addiction 24/516 56/7206 9.84143670443e-14 ko04724 Glutamatergic synapse 40/516 152/7206 1.60835811221e-13 ko04713 Circadian entrainment 35/516 136/7206 1.1286207905e-11 ko04727 GABAergic synapse 30/516 110/7206 7.31066467103e-11 ko04723 Retrograde endocannabinoid signaling 38/516 175/7206 3.43844421721e-10 ko05032 Morphine addiction 29/516 110/7206 3.71607268404e-10 ko04911 Insulin secretion 28/516 117/7206 8.0507569379e-09 ko04728 Dopaminergic synapse 36/516 185/7206 2.26214457276e-08 ko04080 Neuroactive ligand-receptor interaction 62/516 423/7206 2.95663561168e-08 ko04024 cAMP signaling pathway 46/516 279/7206 7.08953156635e-08 ko04726 Serotonergic synapse 29/516 137/7206 8.16781857501e-08 ko04725 Cholinergic synapse 31/516 160/7206 2.43797421926e-07 ko04972 Pancreatic secretion 23/516 111/7206 2.69066381619e-06 ko04970 Salivary secretion 20/516 95/7206 9.37533264233e-06 ko04721 Synaptic vesicle cycle 18/516 80/7206 9.91103634297e-06 ko05031 Amphetamine addiction 19/516 91/7206 1.77342358397e-05 ko04720 Long-term potentiation 20/516 99/7206 1.79247177219e-05 ko05203 Viral carcinogenesis 4/516 277/7206 2.19814796468e-05 ko05030 Cocaine addiction 16/516 73/7206 4.3461866525e-05 ko04020 Calcium signaling pathway 36/516 265/7206 0.000213446639183 ko02010 ABC transporters 10/516 39/7206 0.000310066909735 ko05322 Systemic lupus erythematosus 1/516 151/7206 0.000317221471343 ko04921 Oxytocin signaling pathway 29/516 209/7206 0.000533012920618 ko04261 Adrenergic signaling in cardiomyocytes 28/516 205/7206 0.000820038662795 ko04514 Cell adhesion molecules (CAMs) 20/516 130/7206 0.00092442116799 ko04022 cGMP-PKG signaling pathway 29/516 216/7206 0.00107503436588 ko05169 Epstein-Barr virus infection 4/516 206/7206 0.00137931452502 ko03010 Ribosome 1/516 129/7206 0.00148459567087 ko05166 HTLV-I infection 8/516 292/7206 0.00156642602355 ko05014 Amyotrophic lateral sclerosis (ALS) 13/516 74/7206 0.00204420885877 ko05162 Measles 1/516 120/7206 0.00210488702652 ko04971 Gastric acid secretion 16/516 98/7206 0.00212608542924 ko04070 Phosphatidylinositol signaling system 17/516 112/7206 0.00262420750732 ko03040 Spliceosome 2/516 145/7206 0.00288214551991 ko04710 Circadian rhythm 9/516 43/7206 0.0028903249313 ko04730 Long-term depression 13/516 78/7206 0.00331232781746 ko03013 RNA transport 3/516 166/7206 0.00337291510603 ko05164 Influenza A 3/516 167/7206 0.00340593617617 ko04925 Aldosterone synthesis and secretion 16/516 105/7206 0.00344101071633 ko04120 Ubiquitin mediated proteolysis 2/516 138/7206 0.00407361520508 ko04810 Regulation of actin cytoskeleton 8/516 264/7206 0.00495419798358 ko04740 Olfactory transduction 13/516 80/7206 0.00668614512813 ko04960 Aldosterone-regulated sodium reabsorption 8/516 41/7206 0.00761930567262 ko04014 Ras signaling pathway 32/516 279/7206 0.00856983174519 ko04742 Taste transduction 10/516 61/7206 0.0106393751472 ko04010 MAPK signaling pathway 35/516 321/7206 0.0106875786211 ko05205 Proteoglycans in cancer 9/516 271/7206 0.0109978053904 ko04062 Chemokine signaling pathway 24/516 201/7206 0.0119078160728 ko04141 Protein processing in endoplasmic reticulum 5/516 184/7206 0.013243972133 ko04976 Bile secretion 12/516 80/7206 0.0134777106277 ko04930 Type II diabetes mellitus 9/516 54/7206 0.0135403692751 ko04964 Proximal tubule bicarbonate reclamation 6/516 29/7206 0.0150873344504 ko04745 Phototransduction - fly 7/516 38/7206 0.0167307590218 ko05168 Herpes simplex infection 5/516 182/7206 0.018441435963 ko04540 Gap junction 16/516 128/7206 0.0241135563786 ko05161 Hepatitis B 5/516 173/7206 0.024155485055 ko05224 Breast cancer 5/516 174/7206 0.0242981204983 ko04974 Protein digestion and absorption 13/516 96/7206 0.0252104932446 ko00290 Valine, leucine and isoleucine biosynthesis 2/516 4/7206 0.0278665205237 ko04060 Cytokine-cytokine receptor interaction 6/516 191/7206 0.0312150815377 ko00680 Methane metabolism 6/516 34/7206 0.0315973249346 ko04110 Cell cycle 4/516 145/7206 0.0336497815408 ko04072 Phospholipase D signaling pathway 22/516 197/7206 0.034535721122 ko04626 Plant-pathogen interaction 4/516 18/7206 0.0355517028442 ko04360 Axon guidance 25/516 233/7206 0.0381238756679 ko05130 Pathogenic Escherichia coli infection 1/516 77/7206 0.0426656686281 ko04610 Complement and coagulation cascades 1/516 79/7206 0.0438735316256