ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	155/845	423/7206	1.16128912206e-43
ko05033	Nicotine addiction	47/845	56/7206	1.5045115118e-35
ko04724	Glutamatergic synapse	78/845	152/7206	7.96801291618e-34
ko05032	Morphine addiction	58/845	110/7206	3.72323733143e-26
ko04727	GABAergic synapse	54/845	110/7206	1.78751672302e-22
ko04713	Circadian entrainment	59/845	136/7206	5.01522206965e-21
ko04728	Dopaminergic synapse	69/845	185/7206	5.97115671405e-20
ko04723	Retrograde endocannabinoid signaling	66/845	175/7206	2.00615823462e-19
ko04024	cAMP signaling pathway	87/845	279/7206	5.8349655525e-19
ko04725	Cholinergic synapse	61/845	160/7206	2.66593332759e-18
ko04721	Synaptic vesicle cycle	37/845	80/7206	1.03252569086e-14
ko04911	Insulin secretion	45/845	117/7206	5.7496022903e-14
ko04921	Oxytocin signaling pathway	63/845	209/7206	3.11940789251e-13
ko04020	Calcium signaling pathway	72/845	265/7206	1.91468190947e-12
ko04726	Serotonergic synapse	46/845	137/7206	8.80160625346e-12
ko04742	Taste transduction	28/845	61/7206	2.38742128722e-11
ko05030	Cocaine addiction	31/845	73/7206	2.47814512188e-11
ko05031	Amphetamine addiction	35/845	91/7206	3.80240221371e-11
ko04261	Adrenergic signaling in cardiomyocytes	57/845	205/7206	1.62434331534e-10
ko04720	Long-term potentiation	35/845	99/7206	5.79349442881e-10
ko04010	MAPK signaling pathway	74/845	321/7206	4.38773817668e-09
ko04744	Phototransduction	18/845	36/7206	1.70812221701e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	27/845	74/7206	2.52977287163e-08
ko03040	Spliceosome	1/845	145/7206	3.53069235203e-07
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/845	79/7206	4.90652331876e-07
ko05203	Viral carcinogenesis	10/845	277/7206	2.17765089093e-06
ko04970	Salivary secretion	28/845	95/7206	2.23270920087e-06
ko04972	Pancreatic secretion	30/845	111/7206	7.83641715742e-06
ko04925	Aldosterone synthesis and secretion	29/845	105/7206	8.07602626326e-06
ko04514	Cell adhesion molecules (CAMs)	33/845	130/7206	1.20611451024e-05
ko04360	Axon guidance	50/845	233/7206	1.66947425333e-05
ko05168	Herpes simplex infection	5/845	182/7206	1.88843200745e-05
ko04022	cGMP-PKG signaling pathway	47/845	216/7206	2.10760480057e-05
ko04060	Cytokine-cytokine receptor interaction	6/845	191/7206	3.1052525131e-05
ko04072	Phospholipase D signaling pathway	43/845	197/7206	4.1338380549e-05
ko04260	Cardiac muscle contraction	26/845	98/7206	4.46161712753e-05
ko03013	RNA transport	5/845	166/7206	7.66651094209e-05
ko05164	Influenza A	5/845	167/7206	7.69839110677e-05
ko05414	Dilated cardiomyopathy	28/845	112/7206	7.79910648318e-05
ko05322	Systemic lupus erythematosus	4/845	151/7206	9.3939009604e-05
ko04971	Gastric acid secretion	25/845	98/7206	0.000176538583754
ko04730	Long-term depression	21/845	78/7206	0.000229927578356
ko04740	Olfactory transduction	21/845	80/7206	0.000298831749936
ko04120	Ubiquitin mediated proteolysis	4/845	138/7206	0.000404015825325
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/845	14/7206	0.000484567722873
ko04141	Protein processing in endoplasmic reticulum	8/845	184/7206	0.000683867953484
ko05205	Proteoglycans in cancer	15/845	271/7206	0.000688474135989
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/845	182/7206	0.000951324554749
ko03008	Ribosome biogenesis in eukaryotes	1/845	79/7206	0.00116947158428
ko04540	Gap junction	28/845	128/7206	0.00117843424263
ko04915	Estrogen signaling pathway	28/845	131/7206	0.0013972725557
ko04924	Renin secretion	20/845	86/7206	0.00210199267321
ko05410	Hypertrophic cardiomyopathy (HCM)	22/845	100/7206	0.00275319703929
ko04350	TGF-beta signaling pathway	3/845	103/7206	0.00285963957356
ko00240	Pyrimidine metabolism	4/845	110/7206	0.0042706266111
ko05169	Epstein-Barr virus infection	12/845	206/7206	0.0057253357661
ko05162	Measles	5/845	120/7206	0.00612298041401
ko04070	Phosphatidylinositol signaling system	23/845	112/7206	0.00693440371945
ko04612	Antigen processing and presentation	2/845	77/7206	0.00697630284529
ko04621	NOD-like receptor signaling pathway	8/845	157/7206	0.00782919636641
ko00330	Arginine and proline metabolism	1/845	61/7206	0.00816188487532
ko04930	Type II diabetes mellitus	13/845	54/7206	0.00931898425616
ko04750	Inflammatory mediator regulation of TRP channels	24/845	122/7206	0.00991258037938
ko04014	Ras signaling pathway	47/845	279/7206	0.0100383497742
ko05034	Alcoholism	41/845	238/7206	0.0101619632102
ko04745	Phototransduction - fly	10/845	38/7206	0.0102295728506
ko05140	Leishmaniasis	2/845	75/7206	0.0102296799973
ko04146	Peroxisome	3/845	89/7206	0.0115297948737
ko04964	Proximal tubule bicarbonate reclamation	8/845	29/7206	0.0156310096973
ko03018	RNA degradation	3/845	84/7206	0.015709759406
ko04064	NF-kappa B signaling pathway	4/845	96/7206	0.0159199820087
ko00280	Valine, leucine and isoleucine degradation	1/845	54/7206	0.017688930177
ko04110	Cell cycle	8/845	145/7206	0.0180006400538
ko04140	Autophagy - animal	10/845	164/7206	0.0195421178607
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/845	59/7206	0.0227087908498
ko05161	Hepatitis B	11/845	173/7206	0.0228857075024
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/845	15/7206	0.0240601755202
ko05145	Toxoplasmosis	7/845	126/7206	0.0253302269279
ko00380	Tryptophan metabolism	1/845	50/7206	0.025822039501
ko04966	Collecting duct acid secretion	7/845	26/7206	0.0264369557578
ko04142	Lysosome	9/845	151/7206	0.0285665598294
ko04640	Hematopoietic cell lineage	2/845	64/7206	0.029678179345
ko05016	Huntington's disease	15/845	215/7206	0.0305373689138
ko04371	Apelin signaling pathway	30/845	177/7206	0.0331449035206
ko04976	Bile secretion	16/845	80/7206	0.0334121654702
ko04217	Necroptosis	12/845	178/7206	0.0336177901694
ko00620	Pyruvate metabolism	1/845	46/7206	0.0377628357579
ko03420	Nucleotide excision repair	1/845	46/7206	0.0377628357579
ko00270	Cysteine and methionine metabolism	1/845	47/7206	0.0380681853964
ko04630	Jak-STAT signaling pathway	8/845	132/7206	0.0399938789998
ko05133	Pertussis	4/845	87/7206	0.0419509322226
ko04214	Apoptosis - fly	3/845	72/7206	0.0422337484173
ko00310	Lysine degradation	3/845	73/7206	0.0424979116061
ko04150	mTOR signaling pathway	13/845	184/7206	0.0478705672151