ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 36/587 80/7206 5.3500440079e-19 ko05033 Nicotine addiction 27/587 56/7206 1.72223888371e-15 ko04080 Neuroactive ligand-receptor interaction 82/587 423/7206 2.58142216139e-14 ko04728 Dopaminergic synapse 48/587 185/7206 1.46488111729e-13 ko04724 Glutamatergic synapse 42/587 152/7206 5.26737620981e-13 ko04713 Circadian entrainment 35/587 136/7206 4.18433610923e-10 ko04723 Retrograde endocannabinoid signaling 39/587 175/7206 3.88155967948e-09 ko04727 GABAergic synapse 28/587 110/7206 3.15262867955e-08 ko04360 Axon guidance 44/587 233/7206 1.19704518143e-07 ko05032 Morphine addiction 27/587 110/7206 1.26086567196e-07 ko04911 Insulin secretion 28/587 117/7206 1.31233339445e-07 ko05030 Cocaine addiction 21/587 73/7206 1.81108577614e-07 ko04514 Cell adhesion molecules (CAMs) 29/587 130/7206 3.93409079695e-07 ko04725 Cholinergic synapse 33/587 160/7206 4.36172697968e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 20/587 74/7206 1.07207684412e-06 ko04966 Collecting duct acid secretion 11/587 26/7206 2.37606477503e-06 ko05031 Amphetamine addiction 22/587 91/7206 2.44906085167e-06 ko04024 cAMP signaling pathway 46/587 279/7206 3.02034216157e-06 ko04950 Maturity onset diabetes of the young 11/587 29/7206 8.48045258691e-06 ko04060 Cytokine-cytokine receptor interaction 2/587 191/7206 2.16483752283e-05 ko04261 Adrenergic signaling in cardiomyocytes 35/587 205/7206 2.22781625665e-05 ko04726 Serotonergic synapse 26/587 137/7206 4.24616376884e-05 ko03040 Spliceosome 1/587 145/7206 9.03147742788e-05 ko04742 Taste transduction 14/587 61/7206 0.000299824785467 ko05162 Measles 1/587 120/7206 0.000635237109796 ko04145 Phagosome 26/587 162/7206 0.000694595858595 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/587 59/7206 0.000742231869226 ko03013 RNA transport 3/587 166/7206 0.00080556638356 ko04970 Salivary secretion 18/587 95/7206 0.000852648339012 ko05203 Viral carcinogenesis 9/587 277/7206 0.00107912297428 ko04010 MAPK signaling pathway 43/587 321/7206 0.00109254561334 ko05168 Herpes simplex infection 4/587 182/7206 0.00134446649371 ko04730 Long-term depression 15/587 78/7206 0.00134717592858 ko04120 Ubiquitin mediated proteolysis 2/587 138/7206 0.00135139985783 ko05110 Vibrio cholerae infection 13/587 63/7206 0.00141943277453 ko05120 Epithelial cell signaling in Helicobacter pylori infection 17/587 92/7206 0.00143957985438 ko05322 Systemic lupus erythematosus 3/587 151/7206 0.00230262200147 ko01200 Carbon metabolism 2/587 128/7206 0.00279283165025 ko05164 Influenza A 4/587 167/7206 0.00367156929069 ko04932 Non-alcoholic fatty liver disease (NAFLD) 5/587 182/7206 0.00371344768324 ko04141 Protein processing in endoplasmic reticulum 5/587 184/7206 0.003747520421 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/587 14/7206 0.00379408798193 ko04924 Renin secretion 15/587 86/7206 0.00430298163296 ko05146 Amoebiasis 1/587 99/7206 0.00449839662373 ko04540 Gap junction 20/587 128/7206 0.00470202521541 ko04720 Long-term potentiation 16/587 99/7206 0.00800945987152 ko04146 Peroxisome 1/587 89/7206 0.00956790681511 ko04972 Pancreatic secretion 17/587 111/7206 0.0125342990958 ko04611 Platelet activation 5/587 163/7206 0.0129843907097 ko04110 Cell cycle 4/587 145/7206 0.0130975432355 ko03018 RNA degradation 1/587 84/7206 0.0139261267653 ko04022 cGMP-PKG signaling pathway 28/587 216/7206 0.0154629384029 ko04350 TGF-beta signaling pathway 2/587 103/7206 0.0165356280576 ko05323 Rheumatoid arthritis 14/587 89/7206 0.0167230262061 ko04914 Progesterone-mediated oocyte maturation 2/587 104/7206 0.0168505901196 ko04621 NOD-like receptor signaling pathway 5/587 157/7206 0.0174934483195 ko05169 Epstein-Barr virus infection 8/587 206/7206 0.0195559413066 ko01524 Platinum drug resistance 1/587 76/7206 0.0196360431043 ko03008 Ribosome biogenesis in eukaryotes 1/587 79/7206 0.0202390218337 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 3/587 8/7206 0.0220774893896 ko05205 Proteoglycans in cancer 12/587 271/7206 0.02275685955 ko04064 NF-kappa B signaling pathway 2/587 96/7206 0.0229294812566 ko04630 Jak-STAT signaling pathway 4/587 132/7206 0.0242106086476 ko04964 Proximal tubule bicarbonate reclamation 6/587 29/7206 0.0268649822286 ko04214 Apoptosis - fly 1/587 72/7206 0.0286081976749 ko04140 Autophagy - animal 6/587 164/7206 0.0297703845059 ko00240 Pyrimidine metabolism 3/587 110/7206 0.0335307838566 ko04978 Mineral absorption 7/587 40/7206 0.0404686668945 ko04211 Longevity regulating pathway 4/587 123/7206 0.0447054224853