ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1138	423/7206	6.29438625955e-52
ko04724	Glutamatergic synapse	89/1138	152/7206	4.36202590901e-34
ko05033	Nicotine addiction	47/1138	56/7206	1.66608740879e-29
ko04713	Circadian entrainment	76/1138	136/7206	2.24932567164e-27
ko04727	GABAergic synapse	66/1138	110/7206	2.33165384442e-26
ko05032	Morphine addiction	66/1138	110/7206	2.33165384442e-26
ko04728	Dopaminergic synapse	87/1138	185/7206	3.87166085166e-24
ko04721	Synaptic vesicle cycle	51/1138	80/7206	2.43971295509e-22
ko04725	Cholinergic synapse	77/1138	160/7206	2.98807249634e-22
ko04723	Retrograde endocannabinoid signaling	78/1138	175/7206	5.95497290869e-20
ko04020	Calcium signaling pathway	100/1138	265/7206	1.07261412646e-18
ko04742	Taste transduction	39/1138	61/7206	1.97580159758e-17
ko04911	Insulin secretion	57/1138	117/7206	4.53771228045e-17
ko04024	cAMP signaling pathway	100/1138	279/7206	6.22427612359e-17
ko04726	Serotonergic synapse	62/1138	137/7206	1.76513445701e-16
ko04921	Oxytocin signaling pathway	81/1138	209/7206	4.44160986101e-16
ko04261	Adrenergic signaling in cardiomyocytes	73/1138	205/7206	1.6752548829e-12
ko04970	Salivary secretion	44/1138	95/7206	1.72012618783e-12
ko04720	Long-term potentiation	45/1138	99/7206	2.18327026131e-12
ko05031	Amphetamine addiction	42/1138	91/7206	6.40840146812e-12
ko03040	Spliceosome	1/1138	145/7206	5.15134904132e-10
ko04744	Phototransduction	22/1138	36/7206	7.83196598051e-10
ko04022	cGMP-PKG signaling pathway	69/1138	216/7206	1.84026430439e-09
ko04360	Axon guidance	70/1138	233/7206	2.50460090215e-08
ko04925	Aldosterone synthesis and secretion	40/1138	105/7206	3.33647409994e-08
ko04971	Gastric acid secretion	37/1138	98/7206	1.35325022587e-07
ko04740	Olfactory transduction	32/1138	80/7206	1.44301019515e-07
ko04060	Cytokine-cytokine receptor interaction	7/1138	191/7206	1.61204071043e-07
ko05203	Viral carcinogenesis	16/1138	277/7206	3.31640397502e-07
ko05030	Cocaine addiction	29/1138	73/7206	6.57716934581e-07
ko04010	MAPK signaling pathway	84/1138	321/7206	9.78070036811e-07
ko04540	Gap junction	42/1138	128/7206	1.75863036531e-06
ko04070	Phosphatidylinositol signaling system	38/1138	112/7206	2.39043439856e-06
ko05168	Herpes simplex infection	8/1138	182/7206	2.39187331012e-06
ko04621	NOD-like receptor signaling pathway	6/1138	157/7206	3.66188191195e-06
ko03013	RNA transport	7/1138	166/7206	4.15732786765e-06
ko04141	Protein processing in endoplasmic reticulum	9/1138	184/7206	5.09253091511e-06
ko05322	Systemic lupus erythematosus	6/1138	151/7206	7.3983245644e-06
ko04966	Collecting duct acid secretion	14/1138	26/7206	8.23061743751e-06
ko04120	Ubiquitin mediated proteolysis	5/1138	138/7206	8.77708490433e-06
ko04730	Long-term depression	28/1138	78/7206	1.18807289054e-05
ko05164	Influenza A	8/1138	167/7206	1.32505563154e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1138	74/7206	1.34235576055e-05
ko04972	Pancreatic secretion	35/1138	111/7206	3.14086040238e-05
ko04514	Cell adhesion molecules (CAMs)	39/1138	130/7206	4.41229924902e-05
ko04612	Antigen processing and presentation	1/1138	77/7206	5.04034385347e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1138	79/7206	6.01267428834e-05
ko05110	Vibrio cholerae infection	23/1138	63/7206	6.57534952836e-05
ko04745	Phototransduction - fly	16/1138	38/7206	9.44676952619e-05
ko04371	Apelin signaling pathway	48/1138	177/7206	9.49566056735e-05
ko04072	Phospholipase D signaling pathway	52/1138	197/7206	9.94516116649e-05
ko05414	Dilated cardiomyopathy	34/1138	112/7206	0.000110043577623
ko04924	Renin secretion	28/1138	86/7206	0.000132259555077
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1138	59/7206	0.000188971435654
ko04110	Cell cycle	8/1138	145/7206	0.000199365238021
ko04260	Cardiac muscle contraction	30/1138	98/7206	0.000214250049979
ko04750	Inflammatory mediator regulation of TRP channels	35/1138	122/7206	0.000243936279578
ko04610	Complement and coagulation cascades	2/1138	79/7206	0.000265946336371
ko03008	Ribosome biogenesis in eukaryotes	2/1138	79/7206	0.000265946336371
ko04014	Ras signaling pathway	67/1138	279/7206	0.000289634567782
ko05169	Epstein-Barr virus infection	15/1138	206/7206	0.000305046300625
ko04064	NF-kappa B signaling pathway	4/1138	96/7206	0.000599700677245
ko04915	Estrogen signaling pathway	36/1138	131/7206	0.000603262011185
ko00480	Glutathione metabolism	1/1138	55/7206	0.00133828829245
ko05161	Hepatitis B	13/1138	173/7206	0.00145676549227
ko04923	Regulation of lipolysis in adipocytes	23/1138	77/7206	0.00151800206102
ko04976	Bile secretion	24/1138	80/7206	0.00165559998703
ko04146	Peroxisome	4/1138	89/7206	0.00179522950097
ko05140	Leishmaniasis	3/1138	75/7206	0.0022332227656
ko04964	Proximal tubule bicarbonate reclamation	11/1138	29/7206	0.00320555521202
ko00590	Arachidonic acid metabolism	1/1138	52/7206	0.00324801305385
ko05162	Measles	8/1138	120/7206	0.00351438257397
ko04626	Plant-pathogen interaction	8/1138	18/7206	0.00374452752607
ko04930	Type II diabetes mellitus	17/1138	54/7206	0.00395545563079
ko00330	Arginine and proline metabolism	2/1138	61/7206	0.0040554877025
ko04330	Notch signaling pathway	2/1138	62/7206	0.00423739626188
ko04217	Necroptosis	15/1138	178/7206	0.00476810842039
ko00240	Pyrimidine metabolism	7/1138	110/7206	0.00513650348488
ko04912	GnRH signaling pathway	31/1138	122/7206	0.0055165942464
ko05205	Proteoglycans in cancer	27/1138	271/7206	0.00640259149658
ko05144	Malaria	1/1138	45/7206	0.00680284221006
ko00071	Fatty acid degradation	1/1138	45/7206	0.00680284221006
ko03420	Nucleotide excision repair	1/1138	46/7206	0.00697567084246
ko04270	Vascular smooth muscle contraction	37/1138	154/7206	0.0070331024638
ko04657	IL-17 signaling pathway	5/1138	87/7206	0.00714986734512
ko00562	Inositol phosphate metabolism	24/1138	89/7206	0.00762629430334
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1138	100/7206	0.00809383902142
ko05321	Inflammatory bowel disease (IBD)	2/1138	56/7206	0.00872287884185
ko04350	TGF-beta signaling pathway	7/1138	103/7206	0.00919873619965
ko04115	p53 signaling pathway	4/1138	74/7206	0.00983492504589
ko03018	RNA degradation	5/1138	84/7206	0.00986955298492
ko04916	Melanogenesis	34/1138	142/7206	0.0102018825947
ko01524	Platinum drug resistance	4/1138	76/7206	0.0102648525757
ko03022	Basal transcription factors	1/1138	44/7206	0.0107543792386
ko05145	Toxoplasmosis	10/1138	126/7206	0.0131373556445
ko04622	RIG-I-like receptor signaling pathway	3/1138	62/7206	0.0134647768635
ko05131	Shigellosis	5/1138	82/7206	0.0137813961431
ko04214	Apoptosis - fly	4/1138	72/7206	0.0138514806763
ko00310	Lysine degradation	4/1138	73/7206	0.0141965196722
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1138	14/7206	0.0146816089874
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1138	40/7206	0.0152384544426
ko04630	Jak-STAT signaling pathway	11/1138	132/7206	0.0155680555946
ko00140	Steroid hormone biosynthesis	1/1138	41/7206	0.0157218465292
ko04973	Carbohydrate digestion and absorption	13/1138	42/7206	0.016697222364
ko04210	Apoptosis	17/1138	180/7206	0.0168915006511
ko05133	Pertussis	6/1138	87/7206	0.0177849625966
ko05222	Small cell lung cancer	6/1138	89/7206	0.018120489431
ko04710	Circadian rhythm	13/1138	43/7206	0.0181810436769
ko04922	Glucagon signaling pathway	30/1138	128/7206	0.0201436069996
ko05166	HTLV-I infection	32/1138	292/7206	0.0214573808134
ko00982	Drug metabolism - cytochrome P450	1/1138	37/7206	0.0226240063357
ko03410	Base excision repair	1/1138	38/7206	0.0230665739414
ko04114	Oocyte meiosis	32/1138	139/7206	0.0248697022343
ko05215	Prostate cancer	9/1138	111/7206	0.0249173752737
ko00270	Cysteine and methionine metabolism	2/1138	47/7206	0.0259474409034
ko00260	Glycine, serine and threonine metabolism	2/1138	48/7206	0.0265097175677
ko05418	Fluid shear stress and atherosclerosis	17/1138	173/7206	0.0267107074933
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1138	182/7206	0.0299088755429
ko04510	Focal adhesion	26/1138	240/7206	0.0306647819913
ko04062	Chemokine signaling pathway	43/1138	201/7206	0.0308430153956
ko00640	Propanoate metabolism	1/1138	34/7206	0.0336466955974
ko04015	Rap1 signaling pathway	57/1138	278/7206	0.0355227092061
ko04213	Longevity regulating pathway - multiple species	21/1138	86/7206	0.0360263072287
ko04918	Thyroid hormone synthesis	21/1138	86/7206	0.0360263072287
ko04640	Hematopoietic cell lineage	4/1138	64/7206	0.0371030572894
ko04722	Neurotrophin signaling pathway	35/1138	160/7206	0.0371535177848
ko00620	Pyruvate metabolism	2/1138	46/7206	0.0391270105006
ko05231	Choline metabolism in cancer	30/1138	134/7206	0.0414410890231
ko04711	Circadian rhythm - fly	5/1138	13/7206	0.0415393294205
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1138	92/7206	0.042458319194
ko04668	TNF signaling pathway	11/1138	120/7206	0.043374485707
ko05034	Alcoholism	49/1138	238/7206	0.0462478567513
ko03320	PPAR signaling pathway	5/1138	69/7206	0.0472114730272
ko04658	Th1 and Th2 cell differentiation	8/1138	96/7206	0.0473719960206