ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	210/1351	423/7206	2.99505576935e-50
ko04724	Glutamatergic synapse	92/1351	152/7206	1.14319430358e-30
ko04713	Circadian entrainment	79/1351	136/7206	8.50248118794e-25
ko05033	Nicotine addiction	46/1351	56/7206	9.55607069647e-25
ko04727	GABAergic synapse	69/1351	110/7206	1.49718897657e-24
ko05032	Morphine addiction	69/1351	110/7206	1.49718897657e-24
ko04721	Synaptic vesicle cycle	52/1351	80/7206	8.28928363437e-20
ko04728	Dopaminergic synapse	88/1351	185/7206	1.53146361067e-19
ko04725	Cholinergic synapse	79/1351	160/7206	7.05325076052e-19
ko04020	Calcium signaling pathway	111/1351	265/7206	8.51675581404e-19
ko04723	Retrograde endocannabinoid signaling	81/1351	175/7206	3.52440040356e-17
ko04024	cAMP signaling pathway	111/1351	279/7206	8.12676775506e-17
ko04726	Serotonergic synapse	67/1351	137/7206	6.46309446102e-16
ko04911	Insulin secretion	60/1351	117/7206	1.33104558918e-15
ko04742	Taste transduction	39/1351	61/7206	8.25386339017e-15
ko04921	Oxytocin signaling pathway	86/1351	209/7206	2.34121751448e-14
ko04744	Phototransduction	27/1351	36/7206	3.06522963988e-13
ko04970	Salivary secretion	48/1351	95/7206	1.98904977884e-12
ko05031	Amphetamine addiction	45/1351	91/7206	2.54843545166e-11
ko03010	Ribosome	1/1351	129/7206	1.26252124949e-10
ko04740	Olfactory transduction	40/1351	80/7206	2.13488141726e-10
ko04720	Long-term potentiation	46/1351	99/7206	2.26791404718e-10
ko04261	Adrenergic signaling in cardiomyocytes	75/1351	205/7206	9.73060965395e-10
ko05168	Herpes simplex infection	7/1351	182/7206	2.03516548065e-09
ko04022	cGMP-PKG signaling pathway	77/1351	216/7206	2.54314986087e-09
ko03040	Spliceosome	4/1351	145/7206	8.29428632835e-09
ko04925	Aldosterone synthesis and secretion	45/1351	105/7206	8.89051301966e-09
ko05203	Viral carcinogenesis	19/1351	277/7206	1.59068261283e-08
ko05322	Systemic lupus erythematosus	5/1351	151/7206	1.79871136029e-08
ko03013	RNA transport	7/1351	166/7206	4.8084023588e-08
ko04971	Gastric acid secretion	41/1351	98/7206	1.19629072124e-07
ko04964	Proximal tubule bicarbonate reclamation	18/1351	29/7206	3.10255268697e-07
ko04110	Cell cycle	7/1351	145/7206	1.4021909772e-06
ko04060	Cytokine-cytokine receptor interaction	13/1351	191/7206	3.10165126219e-06
ko04972	Pancreatic secretion	41/1351	111/7206	6.16274186185e-06
ko04070	Phosphatidylinositol signaling system	41/1351	112/7206	7.20183276208e-06
ko04924	Renin secretion	34/1351	86/7206	8.63658664648e-06
ko04540	Gap junction	45/1351	128/7206	9.62627468316e-06
ko04966	Collecting duct acid secretion	15/1351	26/7206	1.10766809257e-05
ko05030	Cocaine addiction	30/1351	73/7206	1.17182692463e-05
ko04730	Long-term depression	31/1351	78/7206	1.3424665642e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1351	79/7206	2.87984008414e-05
ko05164	Influenza A	12/1351	167/7206	3.1345758002e-05
ko04976	Bile secretion	31/1351	80/7206	3.21283723e-05
ko04750	Inflammatory mediator regulation of TRP channels	42/1351	122/7206	3.22366120391e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1351	74/7206	3.4281951022e-05
ko04514	Cell adhesion molecules (CAMs)	44/1351	130/7206	3.45234245157e-05
ko04621	NOD-like receptor signaling pathway	11/1351	157/7206	4.40018335133e-05
ko04745	Phototransduction - fly	18/1351	38/7206	5.37660788491e-05
ko04014	Ras signaling pathway	79/1351	279/7206	8.1851439606e-05
ko04371	Apelin signaling pathway	54/1351	177/7206	0.000126262630415
ko04120	Ubiquitin mediated proteolysis	10/1351	138/7206	0.000160777001138
ko04141	Protein processing in endoplasmic reticulum	16/1351	184/7206	0.000171266831326
ko04010	MAPK signaling pathway	87/1351	321/7206	0.000177563014709
ko04260	Cardiac muscle contraction	34/1351	98/7206	0.000199680258949
ko04270	Vascular smooth muscle contraction	48/1351	154/7206	0.000219771595889
ko05140	Leishmaniasis	3/1351	75/7206	0.000277636539299
ko04360	Axon guidance	66/1351	233/7206	0.000309007696539
ko00520	Amino sugar and nucleotide sugar metabolism	1/1351	55/7206	0.000337571520376
ko05169	Epstein-Barr virus infection	20/1351	206/7206	0.000386256912741
ko04330	Notch signaling pathway	2/1351	62/7206	0.000468404720086
ko04923	Regulation of lipolysis in adipocytes	27/1351	77/7206	0.00060866244041
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1351	59/7206	0.000684795308203
ko05162	Measles	9/1351	120/7206	0.0008345426543
ko05110	Vibrio cholerae infection	23/1351	63/7206	0.000901909136728
ko04915	Estrogen signaling pathway	40/1351	131/7206	0.000964495399225
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1351	79/7206	0.00116596979881
ko05414	Dilated cardiomyopathy	35/1351	112/7206	0.00134685896293
ko05161	Hepatitis B	17/1351	173/7206	0.00151826364437
ko04072	Phospholipase D signaling pathway	55/1351	197/7206	0.0015412624379
ko03022	Basal transcription factors	1/1351	44/7206	0.00170050801185
ko03420	Nucleotide excision repair	1/1351	46/7206	0.00179168300217
ko05166	HTLV-I infection	35/1351	292/7206	0.00211464095412
ko04064	NF-kappa B signaling pathway	7/1351	96/7206	0.00225109926722
ko04626	Plant-pathogen interaction	9/1351	18/7206	0.00264538325615
ko04922	Glucagon signaling pathway	38/1351	128/7206	0.00271646166747
ko04622	RIG-I-like receptor signaling pathway	3/1351	62/7206	0.00277433058644
ko00240	Pyrimidine metabolism	9/1351	110/7206	0.00288315356626
ko04610	Complement and coagulation cascades	5/1351	79/7206	0.00325863330021
ko04657	IL-17 signaling pathway	6/1351	87/7206	0.0032706259708
ko05205	Proteoglycans in cancer	33/1351	271/7206	0.00415898972413
ko04930	Type II diabetes mellitus	19/1351	54/7206	0.00427684269219
ko03018	RNA degradation	6/1351	84/7206	0.0044517903062
ko04710	Circadian rhythm	16/1351	43/7206	0.00481894015493
ko05219	Bladder cancer	2/1351	48/7206	0.00506646803934
ko05131	Shigellosis	6/1351	82/7206	0.00623093778758
ko04916	Melanogenesis	40/1351	142/7206	0.00626004557739
ko04658	Th1 and Th2 cell differentiation	8/1351	96/7206	0.0078290057507
ko05133	Pertussis	7/1351	87/7206	0.00810764977913
ko00562	Inositol phosphate metabolism	27/1351	89/7206	0.00868775316415
ko05321	Inflammatory bowel disease (IBD)	3/1351	56/7206	0.00871062557527
ko04973	Carbohydrate digestion and absorption	15/1351	42/7206	0.00871268314082
ko04214	Apoptosis - fly	5/1351	72/7206	0.00896063498011
ko04612	Antigen processing and presentation	6/1351	77/7206	0.0117487440278
ko04630	Jak-STAT signaling pathway	14/1351	132/7206	0.0131339433296
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1351	100/7206	0.0134274462763
ko04146	Peroxisome	8/1351	89/7206	0.0138831958044
ko04217	Necroptosis	21/1351	178/7206	0.0148197586908
ko05145	Toxoplasmosis	13/1351	126/7206	0.0149497353085
ko04142	Lysosome	17/1351	151/7206	0.0151860854055
ko04350	TGF-beta signaling pathway	10/1351	103/7206	0.0153993971744
ko04960	Aldosterone-regulated sodium reabsorption	14/1351	41/7206	0.0159563092461
ko04213	Longevity regulating pathway - multiple species	25/1351	86/7206	0.0177722959548
ko00471	D-Glutamine and D-glutamate metabolism	3/1351	4/7206	0.022619168942
ko00710	Carbon fixation in photosynthetic organisms	10/1351	27/7206	0.023391885572
ko05416	Viral myocarditis	4/1351	55/7206	0.024146703509
ko04912	GnRH signaling pathway	33/1351	122/7206	0.0253860550212
ko04210	Apoptosis	22/1351	180/7206	0.0255638098218
ko04620	Toll-like receptor signaling pathway	10/1351	100/7206	0.0272036555157
ko04113	Meiosis - yeast	6/1351	70/7206	0.0298760639589
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1351	14/7206	0.0327124821659
ko05212	Pancreatic cancer	8/1351	83/7206	0.0330064357826
ko00280	Valine, leucine and isoleucine degradation	4/1351	54/7206	0.0339993582118
ko05144	Malaria	3/1351	45/7206	0.0346341834737
ko03410	Base excision repair	2/1351	38/7206	0.0346463394386
ko05010	Alzheimer's disease	50/1351	202/7206	0.0349023916321
ko04115	p53 signaling pathway	7/1351	74/7206	0.0364264338631
ko00230	Purine metabolism	48/1351	194/7206	0.0396099848446
ko05214	Glioma	22/1351	79/7206	0.0424329213588
ko00310	Lysine degradation	7/1351	73/7206	0.0487614830664
ko04015	Rap1 signaling pathway	65/1351	278/7206	0.049768391463