ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 37/297 191/7206 9.87498393693e-16 ko05340 Primary immunodeficiency 14/297 30/7206 2.42072640787e-12 ko04380 Osteoclast differentiation 27/297 134/7206 3.53420730576e-12 ko04650 Natural killer cell mediated cytotoxicity 23/297 97/7206 4.3003938116e-12 ko04621 NOD-like receptor signaling pathway 28/297 157/7206 3.06333213915e-11 ko04660 T cell receptor signaling pathway 24/297 124/7206 1.44138624557e-10 ko05140 Leishmaniasis 18/297 75/7206 8.02995931323e-10 ko05162 Measles 22/297 120/7206 2.55594601927e-09 ko04620 Toll-like receptor signaling pathway 20/297 100/7206 2.85955424975e-09 ko04064 NF-kappa B signaling pathway 19/297 96/7206 8.65280640067e-09 ko05152 Tuberculosis 27/297 187/7206 9.15088478232e-09 ko05150 Staphylococcus aureus infection 12/297 36/7206 9.92240822369e-09 ko05164 Influenza A 25/297 167/7206 1.58444201526e-08 ko05145 Toxoplasmosis 21/297 126/7206 3.46707916636e-08 ko05321 Inflammatory bowel disease (IBD) 14/297 56/7206 3.65795972929e-08 ko04610 Complement and coagulation cascades 16/297 79/7206 9.5165756496e-08 ko05330 Allograft rejection 9/297 24/7206 2.30421052616e-07 ko05133 Pertussis 16/297 87/7206 3.87462214495e-07 ko05168 Herpes simplex infection 23/297 182/7206 1.37412418881e-06 ko04662 B cell receptor signaling pathway 15/297 88/7206 2.46442843704e-06 ko05310 Asthma 7/297 17/7206 2.56527090377e-06 ko04659 Th17 cell differentiation 16/297 106/7206 5.92769753392e-06 ko04658 Th1 and Th2 cell differentiation 15/297 96/7206 7.53775487753e-06 ko04062 Chemokine signaling pathway 23/297 201/7206 7.62474352744e-06 ko04640 Hematopoietic cell lineage 12/297 64/7206 9.2181110345e-06 ko05144 Malaria 10/297 45/7206 1.0747085791e-05 ko04664 Fc epsilon RI signaling pathway 13/297 77/7206 1.29952047709e-05 ko05320 Autoimmune thyroid disease 8/297 29/7206 1.52522915652e-05 ko05161 Hepatitis B 20/297 173/7206 2.61170448511e-05 ko04623 Cytosolic DNA-sensing pathway 9/297 41/7206 3.32309138527e-05 ko04666 Fc gamma R-mediated phagocytosis 16/297 122/7206 3.64135590786e-05 ko05332 Graft-versus-host disease 6/297 18/7206 5.68588261326e-05 ko04612 Antigen processing and presentation 12/297 77/7206 6.37985833547e-05 ko04630 Jak-STAT signaling pathway 16/297 132/7206 9.59252698889e-05 ko04672 Intestinal immune network for IgA production 8/297 37/7206 0.000102862924086 ko04611 Platelet activation 18/297 163/7206 0.000120915134858 ko04622 RIG-I-like receptor signaling pathway 10/297 62/7206 0.000194551434112 ko05323 Rheumatoid arthritis 12/297 89/7206 0.000264772728306 ko05142 Chagas disease (American trypanosomiasis) 15/297 130/7206 0.000274655374689 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/297 191/7206 0.000312076439243 ko04217 Necroptosis 18/297 178/7206 0.000366530477677 ko04670 Leukocyte transendothelial migration 16/297 151/7206 0.00045987050696 ko05131 Shigellosis 11/297 82/7206 0.000497051054661 ko05034 Alcoholism 1/297 238/7206 0.000740337892206 ko04145 Phagosome 16/297 162/7206 0.000997000076595 ko04940 Type I diabetes mellitus 6/297 32/7206 0.00170497018268 ko04514 Cell adhesion molecules (CAMs) 13/297 130/7206 0.00261165588727 ko04210 Apoptosis 16/297 180/7206 0.00344981345418 ko04668 TNF signaling pathway 12/297 120/7206 0.00377163717193 ko04142 Lysosome 14/297 151/7206 0.00528184116029 ko05132 Salmonella infection 10/297 98/7206 0.00687298158723 ko04310 Wnt signaling pathway 1/297 181/7206 0.00715708760669 ko04728 Dopaminergic synapse 1/297 185/7206 0.00735357796488 ko05224 Breast cancer 1/297 174/7206 0.0105321253356 ko04723 Retrograde endocannabinoid signaling 1/297 175/7206 0.0106250435592 ko05134 Legionellosis 8/297 74/7206 0.0107523552693 ko05160 Hepatitis C 13/297 153/7206 0.0117774983559 ko04933 AGE-RAGE signaling pathway in diabetic complications 12/297 135/7206 0.012801047309 ko04550 Signaling pathways regulating pluripotency of stem cells 1/297 165/7206 0.0153281637051 ko00590 Arachidonic acid metabolism 6/297 52/7206 0.019278792833 ko03050 Proteasome 6/297 54/7206 0.0228502291245 ko05166 HTLV-I infection 20/297 292/7206 0.0231945558482 ko05020 Prion diseases 5/297 40/7206 0.0232097263066 ko05416 Viral myocarditis 6/297 55/7206 0.0247924080726 ko04390 Hippo signaling pathway 2/297 188/7206 0.024922795224 ko04020 Calcium signaling pathway 4/297 265/7206 0.0261388164444 ko04141 Protein processing in endoplasmic reticulum 2/297 184/7206 0.0358201146156 ko05016 Huntington's disease 3/297 215/7206 0.0358603192508 ko05130 Pathogenic Escherichia coli infection 7/297 77/7206 0.0386663802084 ko05143 African trypanosomiasis 4/297 32/7206 0.0410109286617 ko04915 Estrogen signaling pathway 1/297 131/7206 0.0448103316326