ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1148	423/7206	4.87526713248e-45
ko04724	Glutamatergic synapse	95/1148	152/7206	2.02057533055e-39
ko05033	Nicotine addiction	50/1148	56/7206	6.34934287937e-34
ko04713	Circadian entrainment	81/1148	136/7206	1.52375078749e-31
ko05032	Morphine addiction	71/1148	110/7206	5.97115452114e-31
ko04727	GABAergic synapse	69/1148	110/7206	5.68579707357e-29
ko04728	Dopaminergic synapse	92/1148	185/7206	1.7302308833e-27
ko04725	Cholinergic synapse	78/1148	160/7206	9.93527170109e-23
ko04723	Retrograde endocannabinoid signaling	82/1148	175/7206	2.05144443796e-22
ko04721	Synaptic vesicle cycle	47/1148	80/7206	2.08192365904e-18
ko04911	Insulin secretion	59/1148	117/7206	2.31151902385e-18
ko04024	cAMP signaling pathway	103/1148	279/7206	3.09469228163e-18
ko04020	Calcium signaling pathway	98/1148	265/7206	2.17603643491e-17
ko04726	Serotonergic synapse	62/1148	137/7206	2.72957521472e-16
ko05031	Amphetamine addiction	48/1148	91/7206	3.53676802933e-16
ko04261	Adrenergic signaling in cardiomyocytes	80/1148	205/7206	6.95415289289e-16
ko04921	Oxytocin signaling pathway	80/1148	209/7206	1.9047099892e-15
ko04744	Phototransduction	27/1148	36/7206	4.8333240034e-15
ko04720	Long-term potentiation	48/1148	99/7206	2.56983898273e-14
ko04970	Salivary secretion	46/1148	95/7206	9.55026471754e-14
ko04742	Taste transduction	35/1148	61/7206	1.33711325689e-13
ko05030	Cocaine addiction	37/1148	73/7206	4.49239968563e-12
ko04925	Aldosterone synthesis and secretion	45/1148	105/7206	3.60274229222e-11
ko04971	Gastric acid secretion	42/1148	98/7206	1.63505542911e-10
ko03040	Spliceosome	1/1148	145/7206	5.22000109765e-10
ko04060	Cytokine-cytokine receptor interaction	6/1148	191/7206	1.75391715433e-08
ko04022	cGMP-PKG signaling pathway	67/1148	216/7206	2.22362117564e-08
ko04070	Phosphatidylinositol signaling system	41/1148	112/7206	7.00540483394e-08
ko04740	Olfactory transduction	32/1148	80/7206	1.77682327264e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1148	74/7206	3.03543954878e-07
ko04072	Phospholipase D signaling pathway	59/1148	197/7206	5.23715526566e-07
ko04972	Pancreatic secretion	39/1148	111/7206	5.67040086201e-07
ko04745	Phototransduction - fly	19/1148	38/7206	1.01686985645e-06
ko04730	Long-term depression	30/1148	78/7206	1.16142563545e-06
ko05322	Systemic lupus erythematosus	5/1148	151/7206	1.37289844614e-06
ko04010	MAPK signaling pathway	84/1148	321/7206	1.55292635902e-06
ko05203	Viral carcinogenesis	18/1148	277/7206	2.1665857563e-06
ko03013	RNA transport	7/1148	166/7206	2.81479053309e-06
ko04360	Axon guidance	64/1148	233/7206	6.29860118436e-06
ko05168	Herpes simplex infection	9/1148	182/7206	7.36518224076e-06
ko04915	Estrogen signaling pathway	41/1148	131/7206	9.46068868147e-06
ko04540	Gap junction	40/1148	128/7206	1.31409437692e-05
ko04110	Cell cycle	6/1148	145/7206	1.54109611503e-05
ko04610	Complement and coagulation cascades	1/1148	79/7206	3.29472290647e-05
ko04924	Renin secretion	29/1148	86/7206	3.95232666242e-05
ko04141	Protein processing in endoplasmic reticulum	11/1148	184/7206	5.64341412077e-05
ko05414	Dilated cardiomyopathy	34/1148	112/7206	0.000119264932999
ko05164	Influenza A	10/1148	167/7206	0.000149870369872
ko05110	Vibrio cholerae infection	22/1148	63/7206	0.000183918682567
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1148	59/7206	0.00020596264343
ko04260	Cardiac muscle contraction	30/1148	98/7206	0.000235565430449
ko04923	Regulation of lipolysis in adipocytes	25/1148	77/7206	0.000254640224535
ko03008	Ribosome biogenesis in eukaryotes	2/1148	79/7206	0.000268956335388
ko04976	Bile secretion	26/1148	80/7206	0.00028580896802
ko05169	Epstein-Barr virus infection	15/1148	206/7206	0.000309825796874
ko05162	Measles	6/1148	120/7206	0.000356305202646
ko04912	GnRH signaling pathway	35/1148	122/7206	0.00038528383762
ko04750	Inflammatory mediator regulation of TRP channels	35/1148	122/7206	0.00038528383762
ko04612	Antigen processing and presentation	2/1148	77/7206	0.000411398739418
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1148	79/7206	0.000494547411008
ko04514	Cell adhesion molecules (CAMs)	36/1148	130/7206	0.000603307646234
ko04966	Collecting duct acid secretion	11/1148	26/7206	0.0012157281658
ko04621	NOD-like receptor signaling pathway	11/1148	157/7206	0.00124749875056
ko05205	Proteoglycans in cancer	25/1148	271/7206	0.00164893681004
ko04918	Thyroid hormone synthesis	25/1148	86/7206	0.00171316000134
ko04064	NF-kappa B signaling pathway	5/1148	96/7206	0.00185123921712
ko00590	Arachidonic acid metabolism	1/1148	52/7206	0.00199688639907
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1148	14/7206	0.00312233421767
ko04062	Chemokine signaling pathway	48/1148	201/7206	0.00316810329726
ko04371	Apelin signaling pathway	43/1148	177/7206	0.00341754720387
ko00240	Pyrimidine metabolism	7/1148	110/7206	0.00361092069889
ko04930	Type II diabetes mellitus	17/1148	54/7206	0.00417002756294
ko05034	Alcoholism	54/1148	238/7206	0.00514900478755
ko04630	Jak-STAT signaling pathway	10/1148	132/7206	0.00561040351675
ko03022	Basal transcription factors	1/1148	44/7206	0.00676899450754
ko05144	Malaria	1/1148	45/7206	0.00679913090904
ko04922	Glucagon signaling pathway	32/1148	128/7206	0.00705092414596
ko03420	Nucleotide excision repair	1/1148	46/7206	0.00706585914166
ko04210	Apoptosis	16/1148	180/7206	0.00712323841936
ko04014	Ras signaling pathway	61/1148	279/7206	0.0074787568989
ko04270	Vascular smooth muscle contraction	37/1148	154/7206	0.00748269116852
ko00562	Inositol phosphate metabolism	24/1148	89/7206	0.00790704080109
ko05202	Transcriptional misregulation in cancer	17/1148	188/7206	0.00828802357266
ko05231	Choline metabolism in cancer	33/1148	134/7206	0.00836203732662
ko00480	Glutathione metabolism	2/1148	55/7206	0.00853724634544
ko05321	Inflammatory bowel disease (IBD)	2/1148	56/7206	0.00885209123843
ko04120	Ubiquitin mediated proteolysis	11/1148	138/7206	0.00922288811787
ko04350	TGF-beta signaling pathway	7/1148	103/7206	0.00927567649577
ko04640	Hematopoietic cell lineage	3/1148	64/7206	0.00939774879662
ko04114	Oocyte meiosis	34/1148	139/7206	0.00946673018498
ko04960	Aldosterone-regulated sodium reabsorption	13/1148	41/7206	0.0097078926647
ko04115	p53 signaling pathway	4/1148	74/7206	0.00983395624827
ko05140	Leishmaniasis	4/1148	75/7206	0.0100780683638
ko05016	Huntington's disease	21/1148	215/7206	0.0104518443184
ko04015	Rap1 signaling pathway	60/1148	278/7206	0.0118849375425
ko04146	Peroxisome	6/1148	89/7206	0.0130200132284
ko05222	Small cell lung cancer	6/1148	89/7206	0.0130200132284
ko04622	RIG-I-like receptor signaling pathway	3/1148	62/7206	0.0134989211755
ko04916	Melanogenesis	34/1148	142/7206	0.0143321759986
ko05161	Hepatitis B	16/1148	173/7206	0.0150494586941
ko04626	Plant-pathogen interaction	7/1148	18/7206	0.0161731882531
ko00512	Mucin type O-glycan biosynthesis	10/1148	29/7206	0.0176088505057
ko04964	Proximal tubule bicarbonate reclamation	10/1148	29/7206	0.0176088505057
ko04657	IL-17 signaling pathway	6/1148	87/7206	0.0177091699916
ko05217	Basal cell carcinoma	4/1148	68/7206	0.019083086046
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1148	15/7206	0.0221448009225
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1148	182/7206	0.0235865467236
ko04550	Signaling pathways regulating pluripotency of stem cells	16/1148	165/7206	0.0238729193089
ko03018	RNA degradation	6/1148	84/7206	0.0239433899578
ko05145	Toxoplasmosis	11/1148	126/7206	0.0262668376971
ko05418	Fluid shear stress and atherosclerosis	17/1148	173/7206	0.0266852895082
ko05166	HTLV-I infection	33/1148	292/7206	0.0272735197111
ko05214	Glioma	20/1148	79/7206	0.0293434962584
ko04016	MAPK signaling pathway - plant	7/1148	20/7206	0.0295346691294
ko04510	Focal adhesion	26/1148	240/7206	0.0308048247793
ko00513	Various types of N-glycan biosynthesis	12/1148	42/7206	0.0331408124554
ko04973	Carbohydrate digestion and absorption	12/1148	42/7206	0.0331408124554
ko00860	Porphyrin and chlorophyll metabolism	1/1148	34/7206	0.0334920002845
ko04975	Fat digestion and absorption	1/1148	35/7206	0.0340757579843
ko00500	Starch and sucrose metabolism	1/1148	35/7206	0.0340757579843
ko04214	Apoptosis - fly	5/1148	72/7206	0.0346588012256
ko00310	Lysine degradation	5/1148	73/7206	0.035051008237
ko04330	Notch signaling pathway	4/1148	62/7206	0.0366238360841
ko04213	Longevity regulating pathway - multiple species	21/1148	86/7206	0.0372940573215
ko00071	Fatty acid degradation	2/1148	45/7206	0.0380724640999
ko04711	Circadian rhythm - fly	5/1148	13/7206	0.0429570108037
ko03320	PPAR signaling pathway	5/1148	69/7206	0.0469630190463
ko04113	Meiosis - yeast	5/1148	70/7206	0.0473204816065
ko04658	Th1 and Th2 cell differentiation	8/1148	96/7206	0.0477750317509
ko00515	Mannose type O-glycan biosynthesis	8/1148	25/7206	0.0479757586104
ko04722	Neurotrophin signaling pathway	35/1148	160/7206	0.0483246258001
ko05215	Prostate cancer	10/1148	111/7206	0.0488757534835