ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1295	423/7206	9.9641905457e-56
ko04724	Glutamatergic synapse	98/1295	152/7206	1.22821777368e-37
ko05032	Morphine addiction	75/1295	110/7206	1.940225141e-31
ko05033	Nicotine addiction	50/1295	56/7206	2.57446433197e-31
ko04713	Circadian entrainment	84/1295	136/7206	2.34086294225e-30
ko04727	GABAergic synapse	72/1295	110/7206	1.7503214164e-28
ko04728	Dopaminergic synapse	95/1295	185/7206	1.46956091765e-25
ko04725	Cholinergic synapse	83/1295	160/7206	7.97834798953e-23
ko04723	Retrograde endocannabinoid signaling	83/1295	175/7206	1.36769268319e-19
ko04911	Insulin secretion	64/1295	117/7206	1.99861717407e-19
ko04024	cAMP signaling pathway	113/1295	279/7206	2.03604801329e-19
ko04721	Synaptic vesicle cycle	50/1295	80/7206	7.87129086046e-19
ko04020	Calcium signaling pathway	108/1295	265/7206	9.36594300005e-19
ko04726	Serotonergic synapse	66/1295	137/7206	3.06649305893e-16
ko04921	Oxytocin signaling pathway	87/1295	209/7206	5.00167078734e-16
ko05031	Amphetamine addiction	49/1295	91/7206	8.50043008954e-15
ko04744	Phototransduction	27/1295	36/7206	1.04864824546e-13
ko04742	Taste transduction	37/1295	61/7206	1.13668190278e-13
ko04720	Long-term potentiation	49/1295	99/7206	6.05283361195e-13
ko04261	Adrenergic signaling in cardiomyocytes	79/1295	205/7206	1.78294934995e-12
ko03040	Spliceosome	1/1295	145/7206	1.57276336627e-11
ko04970	Salivary secretion	44/1295	95/7206	1.53625101992e-10
ko04925	Aldosterone synthesis and secretion	47/1295	105/7206	1.56530602628e-10
ko05030	Cocaine addiction	37/1295	73/7206	1.76687508234e-10
ko03010	Ribosome	1/1295	129/7206	3.39353975458e-10
ko04740	Olfactory transduction	38/1295	80/7206	1.12385024294e-09
ko04971	Gastric acid secretion	43/1295	98/7206	2.03867485705e-09
ko05322	Systemic lupus erythematosus	5/1295	151/7206	4.42435690921e-08
ko04022	cGMP-PKG signaling pathway	71/1295	216/7206	1.10224666596e-07
ko03013	RNA transport	7/1295	166/7206	1.71173826284e-07
ko04070	Phosphatidylinositol signaling system	42/1295	112/7206	7.37051751993e-07
ko04010	MAPK signaling pathway	93/1295	321/7206	7.38919351757e-07
ko04961	Endocrine and other factor-regulated calcium reabsorption	27/1295	59/7206	7.47777390699e-07
ko04060	Cytokine-cytokine receptor interaction	11/1295	191/7206	8.02062956373e-07
ko04360	Axon guidance	72/1295	233/7206	1.34174046171e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1295	74/7206	1.65555677518e-06
ko05203	Viral carcinogenesis	22/1295	277/7206	1.99312917793e-06
ko04972	Pancreatic secretion	40/1295	111/7206	4.62038085835e-06
ko04745	Phototransduction - fly	19/1295	38/7206	6.61063899774e-06
ko04141	Protein processing in endoplasmic reticulum	12/1295	184/7206	9.16721636547e-06
ko05168	Herpes simplex infection	12/1295	182/7206	1.292808007e-05
ko04514	Cell adhesion molecules (CAMs)	43/1295	130/7206	2.59354526479e-05
ko04072	Phospholipase D signaling pathway	59/1295	197/7206	2.95492774055e-05
ko04621	NOD-like receptor signaling pathway	10/1295	157/7206	3.3082399111e-05
ko04540	Gap junction	42/1295	128/7206	3.91859973431e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1295	79/7206	4.44190328205e-05
ko04612	Antigen processing and presentation	2/1295	77/7206	6.74973911829e-05
ko04711	Circadian rhythm - fly	9/1295	13/7206	6.79056990061e-05
ko04730	Long-term depression	29/1295	78/7206	7.22665451756e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1295	79/7206	8.08936753576e-05
ko05164	Influenza A	12/1295	167/7206	8.87363444974e-05
ko05414	Dilated cardiomyopathy	37/1295	112/7206	9.84019519739e-05
ko04924	Renin secretion	30/1295	86/7206	0.000171861623122
ko04110	Cell cycle	10/1295	145/7206	0.000171917936164
ko04923	Regulation of lipolysis in adipocytes	27/1295	77/7206	0.000278249578438
ko04610	Complement and coagulation cascades	3/1295	79/7206	0.000302243941682
ko04976	Bile secretion	28/1295	80/7206	0.0003219873884
ko04750	Inflammatory mediator regulation of TRP channels	38/1295	122/7206	0.000323223484509
ko05110	Vibrio cholerae infection	23/1295	63/7206	0.000407494576051
ko00520	Amino sugar and nucleotide sugar metabolism	1/1295	55/7206	0.000545033037885
ko04912	GnRH signaling pathway	37/1295	122/7206	0.000768177661911
ko00590	Arachidonic acid metabolism	1/1295	52/7206	0.000788033043679
ko04915	Estrogen signaling pathway	39/1295	131/7206	0.000794902072916
ko04260	Cardiac muscle contraction	31/1295	98/7206	0.000848914490433
ko04710	Circadian rhythm	17/1295	43/7206	0.000913078796119
ko04918	Thyroid hormone synthesis	28/1295	86/7206	0.000979547406185
ko04371	Apelin signaling pathway	49/1295	177/7206	0.00139026121711
ko05162	Measles	9/1295	120/7206	0.00163646028387
ko03420	Nucleotide excision repair	1/1295	46/7206	0.00177658631912
ko05169	Epstein-Barr virus infection	21/1295	206/7206	0.00228234909858
ko04014	Ras signaling pathway	70/1295	279/7206	0.0024234652486
ko05321	Inflammatory bowel disease (IBD)	2/1295	56/7206	0.00244672710227
ko03022	Basal transcription factors	1/1295	44/7206	0.00268335416054
ko05144	Malaria	1/1295	45/7206	0.00273887933004
ko00071	Fatty acid degradation	1/1295	45/7206	0.00273887933004
ko00310	Lysine degradation	4/1295	73/7206	0.00316230764349
ko04115	p53 signaling pathway	4/1295	74/7206	0.0032820730128
ko04966	Collecting duct acid secretion	11/1295	26/7206	0.00332642830859
ko04622	RIG-I-like receptor signaling pathway	3/1295	62/7206	0.00416678831336
ko04064	NF-kappa B signaling pathway	7/1295	96/7206	0.00451814072108
ko04916	Melanogenesis	39/1295	142/7206	0.00542016192182
ko00240	Pyrimidine metabolism	9/1295	110/7206	0.00551010777377
ko05205	Proteoglycans in cancer	32/1295	271/7206	0.00599746823027
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1295	14/7206	0.00629870653992
ko03018	RNA degradation	6/1295	84/7206	0.0063383728139
ko04930	Type II diabetes mellitus	18/1295	54/7206	0.00654727691816
ko05202	Transcriptional misregulation in cancer	20/1295	188/7206	0.00681435445569
ko04922	Glucagon signaling pathway	35/1295	128/7206	0.00739403282678
ko04626	Plant-pathogen interaction	8/1295	18/7206	0.00845746981563
ko05131	Shigellosis	6/1295	82/7206	0.00874555604747
ko05231	Choline metabolism in cancer	36/1295	134/7206	0.00891918151644
ko03410	Base excision repair	1/1295	38/7206	0.00941985697056
ko04217	Necroptosis	19/1295	178/7206	0.00980490381755
ko04658	Th1 and Th2 cell differentiation	8/1295	96/7206	0.0106291879116
ko04146	Peroxisome	7/1295	89/7206	0.0115774738814
ko04630	Jak-STAT signaling pathway	13/1295	132/7206	0.0116618221386
ko04964	Proximal tubule bicarbonate reclamation	11/1295	29/7206	0.0120029765371
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1295	100/7206	0.012207657644
ko00280	Valine, leucine and isoleucine degradation	3/1295	54/7206	0.0123289914981
ko00480	Glutathione metabolism	3/1295	55/7206	0.0124374227572
ko04960	Aldosterone-regulated sodium reabsorption	14/1295	41/7206	0.0125270213071
ko04640	Hematopoietic cell lineage	4/1295	64/7206	0.0129372444772
ko04270	Vascular smooth muscle contraction	40/1295	154/7206	0.0141354695365
ko04973	Carbohydrate digestion and absorption	14/1295	42/7206	0.0145353871393
ko04657	IL-17 signaling pathway	7/1295	87/7206	0.0158759877263
ko05133	Pertussis	7/1295	87/7206	0.0158759877263
ko03320	PPAR signaling pathway	5/1295	69/7206	0.0172879911256
ko00562	Inositol phosphate metabolism	25/1295	89/7206	0.0174519368695
ko04142	Lysosome	16/1295	151/7206	0.0178469873117
ko00330	Arginine and proline metabolism	4/1295	61/7206	0.017864272118
ko00860	Porphyrin and chlorophyll metabolism	1/1295	34/7206	0.0219987456349
ko05140	Leishmaniasis	6/1295	75/7206	0.0224376432403
ko04210	Apoptosis	21/1295	180/7206	0.0236926221362
ko05016	Huntington's disease	26/1295	215/7206	0.0237407509634
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1295	182/7206	0.0239532446213
ko04120	Ubiquitin mediated proteolysis	15/1295	138/7206	0.0252725458836
ko05145	Toxoplasmosis	13/1295	126/7206	0.0253633154141
ko05222	Small cell lung cancer	8/1295	89/7206	0.0254928221828
ko05418	Fluid shear stress and atherosclerosis	20/1295	173/7206	0.0269617316149
ko05161	Hepatitis B	20/1295	173/7206	0.0269617316149
ko00230	Purine metabolism	47/1295	194/7206	0.028671885067
ko04214	Apoptosis - fly	6/1295	72/7206	0.0302971526187
ko04114	Oocyte meiosis	35/1295	139/7206	0.0332668515772
ko04620	Toll-like receptor signaling pathway	10/1295	100/7206	0.035545335623
ko00260	Glycine, serine and threonine metabolism	3/1295	48/7206	0.0359375964502
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1295	40/7206	0.0359569681154
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1295	15/7206	0.0382637733851
ko00513	Various types of N-glycan biosynthesis	13/1295	42/7206	0.0409584351079
ko04012	ErbB signaling pathway	28/1295	109/7206	0.0433439237243
ko04213	Longevity regulating pathway - multiple species	23/1295	86/7206	0.0463337057888
ko05215	Prostate cancer	12/1295	111/7206	0.0464056277656
ko05320	Autoimmune thyroid disease	1/1295	29/7206	0.0483771052328
ko04062	Chemokine signaling pathway	47/1295	201/7206	0.0499036418232