ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1237	423/7206	1.47490859542e-53
ko04724	Glutamatergic synapse	92/1237	152/7206	8.00082231916e-34
ko05033	Nicotine addiction	49/1237	56/7206	9.48967947601e-31
ko05032	Morphine addiction	72/1237	110/7206	8.45733590136e-30
ko04727	GABAergic synapse	70/1237	110/7206	7.23226409604e-28
ko04713	Circadian entrainment	79/1237	136/7206	1.90996475138e-27
ko04728	Dopaminergic synapse	86/1237	185/7206	6.60985266398e-21
ko04723	Retrograde endocannabinoid signaling	81/1237	175/7206	1.33059856889e-19
ko04725	Cholinergic synapse	76/1237	160/7206	2.77152474433e-19
ko04024	cAMP signaling pathway	109/1237	279/7206	7.72641484965e-19
ko04020	Calcium signaling pathway	105/1237	265/7206	9.35018162283e-19
ko04721	Synaptic vesicle cycle	48/1237	80/7206	6.33690161989e-18
ko04726	Serotonergic synapse	65/1237	137/7206	1.26409061734e-16
ko04921	Oxytocin signaling pathway	80/1237	209/7206	1.9917620531e-13
ko04911	Insulin secretion	54/1237	117/7206	2.1303805561e-13
ko04744	Phototransduction	26/1237	36/7206	4.387872118e-13
ko05031	Amphetamine addiction	44/1237	91/7206	5.12097008823e-12
ko04742	Taste transduction	34/1237	61/7206	8.47213503428e-12
ko04970	Salivary secretion	44/1237	95/7206	3.20189605606e-11
ko04022	cGMP-PKG signaling pathway	76/1237	216/7206	8.70395654127e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1237	205/7206	1.03769760652e-10
ko04720	Long-term potentiation	44/1237	99/7206	1.73464356222e-10
ko03010	Ribosome	1/1237	129/7206	9.3875717244e-10
ko03040	Spliceosome	2/1237	145/7206	9.65543421449e-10
ko05030	Cocaine addiction	34/1237	73/7206	4.73293821426e-09
ko05322	Systemic lupus erythematosus	4/1237	151/7206	2.33053343252e-08
ko04925	Aldosterone synthesis and secretion	42/1237	105/7206	2.33216203965e-08
ko04971	Gastric acid secretion	38/1237	98/7206	4.41240948485e-07
ko05203	Viral carcinogenesis	19/1237	277/7206	5.29055778576e-07
ko03013	RNA transport	7/1237	166/7206	5.82482713512e-07
ko04740	Olfactory transduction	32/1237	80/7206	1.27561503973e-06
ko04070	Phosphatidylinositol signaling system	40/1237	112/7206	1.73880091149e-06
ko04730	Long-term depression	31/1237	78/7206	2.14307895712e-06
ko04924	Renin secretion	33/1237	86/7206	2.16827256214e-06
ko05168	Herpes simplex infection	10/1237	182/7206	3.34141996689e-06
ko04060	Cytokine-cytokine receptor interaction	12/1237	191/7206	9.86147321111e-06
ko05169	Epstein-Barr virus infection	14/1237	206/7206	1.36069993824e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1237	74/7206	1.75041437962e-05
ko04966	Collecting duct acid secretion	14/1237	26/7206	2.22472178225e-05
ko05164	Influenza A	10/1237	167/7206	2.57115374123e-05
ko04141	Protein processing in endoplasmic reticulum	12/1237	184/7206	2.62168436139e-05
ko04072	Phospholipase D signaling pathway	57/1237	197/7206	3.1689177292e-05
ko04972	Pancreatic secretion	37/1237	111/7206	3.32079951049e-05
ko04110	Cell cycle	8/1237	145/7206	4.74507812791e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1237	79/7206	7.16801000959e-05
ko04010	MAPK signaling pathway	82/1237	321/7206	0.000103845701659
ko04371	Apelin signaling pathway	51/1237	177/7206	0.000105006879856
ko04923	Regulation of lipolysis in adipocytes	27/1237	77/7206	0.000177719373259
ko04540	Gap junction	39/1237	128/7206	0.000198120941435
ko04514	Cell adhesion molecules (CAMs)	39/1237	130/7206	0.000241531033594
ko04014	Ras signaling pathway	72/1237	279/7206	0.000244770471187
ko05166	HTLV-I infection	28/1237	292/7206	0.00024992504062
ko04710	Circadian rhythm	17/1237	43/7206	0.000413859655895
ko05161	Hepatitis B	14/1237	173/7206	0.000705565264356
ko04270	Vascular smooth muscle contraction	43/1237	154/7206	0.000737925343962
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1237	79/7206	0.000742956976556
ko00520	Amino sugar and nucleotide sugar metabolism	1/1237	55/7206	0.000866932954745
ko04745	Phototransduction - fly	15/1237	38/7206	0.000913731925801
ko04260	Cardiac muscle contraction	30/1237	98/7206	0.00101437706107
ko05162	Measles	8/1237	120/7206	0.00131465347431
ko05414	Dilated cardiomyopathy	33/1237	112/7206	0.00137466429151
ko04915	Estrogen signaling pathway	37/1237	131/7206	0.00143843813986
ko04750	Inflammatory mediator regulation of TRP channels	35/1237	122/7206	0.00146091263774
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1237	59/7206	0.00154086869999
ko05110	Vibrio cholerae infection	21/1237	63/7206	0.00198364586312
ko05231	Choline metabolism in cancer	37/1237	134/7206	0.0024091753567
ko04120	Ubiquitin mediated proteolysis	11/1237	138/7206	0.00279865264348
ko03420	Nucleotide excision repair	1/1237	46/7206	0.00280667267176
ko04930	Type II diabetes mellitus	18/1237	54/7206	0.00330544266053
ko04612	Antigen processing and presentation	4/1237	77/7206	0.00336473433508
ko04350	TGF-beta signaling pathway	7/1237	103/7206	0.00342850400466
ko04922	Glucagon signaling pathway	35/1237	128/7206	0.00416560838731
ko03022	Basal transcription factors	1/1237	44/7206	0.00424342117517
ko05144	Malaria	1/1237	45/7206	0.00439485567162
ko04630	Jak-STAT signaling pathway	11/1237	132/7206	0.0049114525174
ko05205	Proteoglycans in cancer	30/1237	271/7206	0.00520508672244
ko04360	Axon guidance	56/1237	233/7206	0.0061248260718
ko04330	Notch signaling pathway	3/1237	62/7206	0.00621598404922
ko04622	RIG-I-like receptor signaling pathway	3/1237	62/7206	0.00621598404922
ko04626	Plant-pathogen interaction	8/1237	18/7206	0.00635973089056
ko04658	Th1 and Th2 cell differentiation	7/1237	96/7206	0.0088933799147
ko05217	Basal cell carcinoma	4/1237	68/7206	0.00927902359219
ko04621	NOD-like receptor signaling pathway	15/1237	157/7206	0.00979985840958
ko00240	Pyrimidine metabolism	9/1237	110/7206	0.0102591042883
ko04976	Bile secretion	23/1237	80/7206	0.010299850749
ko03018	RNA degradation	6/1237	84/7206	0.0125201872647
ko04115	p53 signaling pathway	5/1237	74/7206	0.0128763709592
ko00630	Glyoxylate and dicarboxylate metabolism	1/1237	38/7206	0.0151212835151
ko03410	Base excision repair	1/1237	38/7206	0.0151212835151
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1237	100/7206	0.0152753575192
ko04146	Peroxisome	7/1237	89/7206	0.0158659707009
ko05222	Small cell lung cancer	7/1237	89/7206	0.0158659707009
ko00071	Fatty acid degradation	2/1237	45/7206	0.0170704876817
ko05131	Shigellosis	6/1237	82/7206	0.0172904700392
ko00290	Valine, leucine and isoleucine biosynthesis	3/1237	4/7206	0.0175989387103
ko04214	Apoptosis - fly	5/1237	72/7206	0.0177796560409
ko00310	Lysine degradation	5/1237	73/7206	0.0180517617677
ko00280	Valine, leucine and isoleucine degradation	3/1237	54/7206	0.0181428279669
ko00480	Glutathione metabolism	3/1237	55/7206	0.018279901621
ko05416	Viral myocarditis	3/1237	55/7206	0.018279901621
ko04064	NF-kappa B signaling pathway	8/1237	96/7206	0.0197497417156
ko04657	IL-17 signaling pathway	7/1237	87/7206	0.0213894435932
ko05133	Pertussis	7/1237	87/7206	0.0213894435932
ko05215	Prostate cancer	10/1237	111/7206	0.0216057997895
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1237	14/7206	0.021795458971
ko00562	Inositol phosphate metabolism	24/1237	89/7206	0.0223511556066
ko04964	Proximal tubule bicarbonate reclamation	10/1237	29/7206	0.0227307242408
ko05145	Toxoplasmosis	12/1237	126/7206	0.0227369526003
ko04973	Carbohydrate digestion and absorption	13/1237	42/7206	0.0236281414515
ko04210	Apoptosis	20/1237	180/7206	0.0275279148128
ko04550	Signaling pathways regulating pluripotency of stem cells	18/1237	165/7206	0.0283988475606
ko00010	Glycolysis / Gluconeogenesis	20/1237	74/7206	0.0295897753373
ko05200	Pathways in cancer	67/1237	492/7206	0.0301432797524
ko05140	Leishmaniasis	6/1237	75/7206	0.0310755978631
ko05418	Fluid shear stress and atherosclerosis	19/1237	173/7206	0.0314561129426
ko05130	Pathogenic Escherichia coli infection	6/1237	77/7206	0.0318017713901
ko02010	ABC transporters	12/1237	39/7206	0.0320173343991
ko04217	Necroptosis	20/1237	178/7206	0.0341541204126
ko00680	Methane metabolism	11/1237	34/7206	0.0357858619164
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1237	40/7206	0.0358486754861
ko04510	Focal adhesion	29/1237	240/7206	0.0362169795569
ko04912	GnRH signaling pathway	30/1237	122/7206	0.0384657313066
ko04666	Fc gamma R-mediated phagocytosis	30/1237	122/7206	0.0384657313066
ko04918	Thyroid hormone synthesis	22/1237	86/7206	0.0436242087181
ko05321	Inflammatory bowel disease (IBD)	4/1237	56/7206	0.0489186919832
ko05202	Transcriptional misregulation in cancer	22/1237	188/7206	0.049327064513