ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1227	423/7206	1.82802588121e-53
ko04724	Glutamatergic synapse	91/1227	152/7206	3.20992104058e-33
ko05032	Morphine addiction	70/1227	110/7206	4.30486273436e-28
ko05033	Nicotine addiction	47/1227	56/7206	5.40901094678e-28
ko04713	Circadian entrainment	79/1227	136/7206	1.08204668574e-27
ko04727	GABAergic synapse	67/1227	110/7206	2.60800406107e-25
ko04728	Dopaminergic synapse	88/1227	185/7206	1.77871402029e-22
ko04721	Synaptic vesicle cycle	52/1227	80/7206	8.89291755627e-22
ko04725	Cholinergic synapse	77/1227	160/7206	3.56414338929e-20
ko04020	Calcium signaling pathway	106/1227	265/7206	1.31954361591e-19
ko04723	Retrograde endocannabinoid signaling	80/1227	175/7206	3.46996395013e-19
ko04024	cAMP signaling pathway	105/1227	279/7206	3.89857028764e-17
ko04911	Insulin secretion	59/1227	117/7206	6.13747648403e-17
ko04742	Taste transduction	39/1227	61/7206	2.85304539323e-16
ko04921	Oxytocin signaling pathway	84/1227	209/7206	9.50348893614e-16
ko04726	Serotonergic synapse	63/1227	137/7206	1.67058896175e-15
ko04970	Salivary secretion	47/1227	95/7206	2.37828364522e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1227	205/7206	9.31308223758e-12
ko05031	Amphetamine addiction	43/1227	91/7206	1.78562902074e-11
ko04720	Long-term potentiation	45/1227	99/7206	3.1776223165e-11
ko04744	Phototransduction	24/1227	36/7206	4.47554912415e-11
ko03040	Spliceosome	1/1227	145/7206	7.11046675844e-11
ko04925	Aldosterone synthesis and secretion	44/1227	105/7206	1.32721890311e-09
ko04022	cGMP-PKG signaling pathway	72/1227	216/7206	3.24496002947e-09
ko04740	Olfactory transduction	36/1227	80/7206	4.2423499575e-09
ko04971	Gastric acid secretion	41/1227	98/7206	5.151667744e-09
ko05203	Viral carcinogenesis	16/1227	277/7206	1.91614988481e-08
ko04360	Axon guidance	74/1227	233/7206	2.22467115615e-08
ko04060	Cytokine-cytokine receptor interaction	9/1227	191/7206	2.57886151233e-07
ko03013	RNA transport	7/1227	166/7206	5.68457308395e-07
ko04540	Gap junction	45/1227	128/7206	5.8038578931e-07
ko04924	Renin secretion	34/1227	86/7206	6.28405961831e-07
ko05030	Cocaine addiction	30/1227	73/7206	9.36053749841e-07
ko05322	Systemic lupus erythematosus	6/1227	151/7206	9.91118213449e-07
ko05168	Herpes simplex infection	9/1227	182/7206	1.08982786374e-06
ko04972	Pancreatic secretion	40/1227	111/7206	1.21332770343e-06
ko05164	Influenza A	8/1227	167/7206	1.97384717137e-06
ko04966	Collecting duct acid secretion	15/1227	26/7206	3.20288337042e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1227	74/7206	5.39011322071e-06
ko04010	MAPK signaling pathway	86/1227	321/7206	6.46372413258e-06
ko04514	Cell adhesion molecules (CAMs)	43/1227	130/7206	8.42314529605e-06
ko04976	Bile secretion	30/1227	80/7206	1.40243524565e-05
ko04120	Ubiquitin mediated proteolysis	7/1227	138/7206	3.05559681633e-05
ko04070	Phosphatidylinositol signaling system	37/1227	112/7206	3.4100744642e-05
ko04621	NOD-like receptor signaling pathway	9/1227	157/7206	3.52675025194e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1227	122/7206	4.51129564128e-05
ko04730	Long-term depression	28/1227	78/7206	5.15121827542e-05
ko05110	Vibrio cholerae infection	24/1227	63/7206	5.82434374838e-05
ko04745	Phototransduction - fly	17/1227	38/7206	6.0087163707e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1227	59/7206	6.32089964221e-05
ko04141	Protein processing in endoplasmic reticulum	13/1227	184/7206	9.25442812028e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1227	79/7206	0.000111596311226
ko05169	Epstein-Barr virus infection	16/1227	206/7206	0.000147605147752
ko04371	Apelin signaling pathway	50/1227	177/7206	0.000157111797867
ko05414	Dilated cardiomyopathy	35/1227	112/7206	0.000189645063755
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1227	79/7206	0.000211200891906
ko05162	Measles	7/1227	120/7206	0.000344332863052
ko04260	Cardiac muscle contraction	31/1227	98/7206	0.000347639780428
ko04964	Proximal tubule bicarbonate reclamation	13/1227	29/7206	0.000434667753906
ko04014	Ras signaling pathway	70/1227	279/7206	0.000457780511134
ko04110	Cell cycle	10/1227	145/7206	0.000478593227146
ko04072	Phospholipase D signaling pathway	53/1227	197/7206	0.000482828175295
ko04064	NF-kappa B signaling pathway	5/1227	96/7206	0.000874964530959
ko05140	Leishmaniasis	3/1227	75/7206	0.000989279005697
ko04626	Plant-pathogen interaction	9/1227	18/7206	0.00130545648831
ko04916	Melanogenesis	39/1227	142/7206	0.00150522592788
ko00330	Arginine and proline metabolism	2/1227	61/7206	0.00173007913935
ko04923	Regulation of lipolysis in adipocytes	24/1227	77/7206	0.00200561967112
ko05161	Hepatitis B	15/1227	173/7206	0.00201689027322
ko04915	Estrogen signaling pathway	36/1227	131/7206	0.00220814444681
ko04630	Jak-STAT signaling pathway	10/1227	132/7206	0.00221054893676
ko04610	Complement and coagulation cascades	4/1227	79/7206	0.00231952594386
ko04146	Peroxisome	5/1227	89/7206	0.00250594656171
ko03420	Nucleotide excision repair	1/1227	46/7206	0.00283980329749
ko04612	Antigen processing and presentation	4/1227	77/7206	0.00332804954079
ko05321	Inflammatory bowel disease (IBD)	2/1227	56/7206	0.00375245718077
ko05205	Proteoglycans in cancer	29/1227	271/7206	0.00382751334891
ko05145	Toxoplasmosis	10/1227	126/7206	0.00399292151598
ko03022	Basal transcription factors	1/1227	44/7206	0.00426373320169
ko05144	Malaria	1/1227	45/7206	0.00435029224922
ko00071	Fatty acid degradation	1/1227	45/7206	0.00435029224922
ko00240	Pyrimidine metabolism	8/1227	110/7206	0.00453300969715
ko04270	Vascular smooth muscle contraction	40/1227	154/7206	0.00458642161816
ko00480	Glutathione metabolism	2/1227	55/7206	0.00579954382747
ko04217	Necroptosis	17/1227	178/7206	0.00613567738402
ko04622	RIG-I-like receptor signaling pathway	3/1227	62/7206	0.00625170645127
ko00310	Lysine degradation	4/1227	73/7206	0.00690875845342
ko00590	Arachidonic acid metabolism	2/1227	52/7206	0.00826821054272
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1227	182/7206	0.00903408698047
ko04657	IL-17 signaling pathway	6/1227	87/7206	0.00915723072254
ko05133	Pertussis	6/1227	87/7206	0.00915723072254
ko04912	GnRH signaling pathway	32/1227	122/7206	0.0101625683418
ko05215	Prostate cancer	9/1227	111/7206	0.0103344840854
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1227	100/7206	0.0106146840253
ko05219	Bladder cancer	2/1227	48/7206	0.0117715521263
ko00380	Tryptophan metabolism	2/1227	50/7206	0.0123343374054
ko03018	RNA degradation	6/1227	84/7206	0.0124817572734
ko04710	Circadian rhythm	14/1227	43/7206	0.0126015090261
ko04918	Thyroid hormone synthesis	24/1227	86/7206	0.0130889519505
ko01524	Platinum drug resistance	5/1227	76/7206	0.013111695819
ko03410	Base excision repair	1/1227	38/7206	0.0149536956439
ko04620	Toll-like receptor signaling pathway	8/1227	100/7206	0.0150307591389
ko05131	Shigellosis	6/1227	82/7206	0.0171333618863
ko04214	Apoptosis - fly	5/1227	72/7206	0.0178634248825
ko04930	Type II diabetes mellitus	16/1227	54/7206	0.0180830029323
ko04115	p53 signaling pathway	5/1227	74/7206	0.0183487463454
ko04640	Hematopoietic cell lineage	4/1227	64/7206	0.0183981015994
ko04658	Th1 and Th2 cell differentiation	8/1227	96/7206	0.0197448984923
ko04210	Apoptosis	19/1227	180/7206	0.0203517107776
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1227	14/7206	0.0209827829523
ko05222	Small cell lung cancer	7/1227	89/7206	0.0219641643357
ko04330	Notch signaling pathway	4/1227	62/7206	0.0258542771388
ko00280	Valine, leucine and isoleucine degradation	3/1227	54/7206	0.0269167299279
ko05166	HTLV-I infection	36/1227	292/7206	0.0314984948322
ko00562	Inositol phosphate metabolism	23/1227	89/7206	0.0325798877175
ko04922	Glucagon signaling pathway	31/1227	128/7206	0.0327772511255
ko04015	Rap1 signaling pathway	61/1227	278/7206	0.0339267373008
ko03320	PPAR signaling pathway	5/1227	69/7206	0.0345152955534
ko04140	Autophagy - animal	18/1227	164/7206	0.0355298728722
ko04114	Oocyte meiosis	33/1227	139/7206	0.0397516075483
ko01200	Carbon metabolism	13/1227	128/7206	0.042640289697
ko05340	Primary immunodeficiency	1/1227	30/7206	0.0486752192278
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1227	92/7206	0.0496289581261