ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1053	423/7206	2.34379047144e-45
ko04724	Glutamatergic synapse	86/1053	152/7206	4.86110859723e-34
ko05033	Nicotine addiction	47/1053	56/7206	4.52809254045e-31
ko04727	GABAergic synapse	65/1053	110/7206	1.97162255211e-27
ko05032	Morphine addiction	65/1053	110/7206	1.97162255211e-27
ko04713	Circadian entrainment	70/1053	136/7206	1.61714693582e-24
ko04728	Dopaminergic synapse	82/1053	185/7206	5.43476185773e-23
ko04721	Synaptic vesicle cycle	50/1053	80/7206	6.56560996684e-23
ko04725	Cholinergic synapse	74/1053	160/7206	3.31341158853e-22
ko04723	Retrograde endocannabinoid signaling	76/1053	175/7206	1.02262601905e-20
ko04742	Taste transduction	37/1053	61/7206	1.21188848948e-16
ko04024	cAMP signaling pathway	94/1053	279/7206	2.73880027306e-16
ko04744	Phototransduction	27/1053	36/7206	5.21674774591e-16
ko04020	Calcium signaling pathway	90/1053	265/7206	9.41331137665e-16
ko04911	Insulin secretion	52/1053	117/7206	4.86635345363e-15
ko04921	Oxytocin signaling pathway	74/1053	209/7206	2.60953384767e-14
ko04726	Serotonergic synapse	56/1053	137/7206	3.59619446418e-14
ko05031	Amphetamine addiction	40/1053	91/7206	1.12219428694e-11
ko04720	Long-term potentiation	42/1053	99/7206	1.41279692334e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1053	205/7206	3.13492098784e-11
ko04970	Salivary secretion	38/1053	95/7206	1.04758984101e-09
ko03040	Spliceosome	1/1053	145/7206	3.54025073596e-09
ko05168	Herpes simplex infection	5/1053	182/7206	1.08071351777e-07
ko05203	Viral carcinogenesis	13/1053	277/7206	1.28240974993e-07
ko04971	Gastric acid secretion	35/1053	98/7206	1.42853553368e-07
ko04740	Olfactory transduction	30/1053	80/7206	3.28844081139e-07
ko04925	Aldosterone synthesis and secretion	36/1053	105/7206	3.61839515009e-07
ko04966	Collecting duct acid secretion	15/1053	26/7206	4.2570805841e-07
ko05030	Cocaine addiction	28/1053	73/7206	4.71374713335e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1053	74/7206	6.54275526509e-07
ko05164	Influenza A	5/1053	167/7206	1.09658439734e-06
ko04120	Ubiquitin mediated proteolysis	3/1053	138/7206	1.18414039164e-06
ko04621	NOD-like receptor signaling pathway	5/1053	157/7206	3.24824307492e-06
ko04360	Axon guidance	60/1053	233/7206	7.05978435057e-06
ko04745	Phototransduction - fly	17/1053	38/7206	7.63810811785e-06
ko04060	Cytokine-cytokine receptor interaction	9/1053	191/7206	1.60206780955e-05
ko03013	RNA transport	7/1053	166/7206	1.91144433998e-05
ko04924	Renin secretion	28/1053	86/7206	2.0296992484e-05
ko04010	MAPK signaling pathway	75/1053	321/7206	2.23777976403e-05
ko04141	Protein processing in endoplasmic reticulum	9/1053	184/7206	3.11900406895e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1053	79/7206	3.40563903214e-05
ko04972	Pancreatic secretion	33/1053	111/7206	3.45106974733e-05
ko05322	Systemic lupus erythematosus	6/1053	151/7206	3.45555416372e-05
ko04514	Cell adhesion molecules (CAMs)	37/1053	130/7206	4.22266333175e-05
ko05110	Vibrio cholerae infection	22/1053	63/7206	4.44562369047e-05
ko04022	cGMP-PKG signaling pathway	54/1053	216/7206	4.94764827926e-05
ko04730	Long-term depression	25/1053	78/7206	7.50668421935e-05
ko05169	Epstein-Barr virus infection	12/1053	206/7206	8.47387561865e-05
ko05414	Dilated cardiomyopathy	32/1053	112/7206	0.000118273663597
ko04070	Phosphatidylinositol signaling system	32/1053	112/7206	0.000118273663597
ko04612	Antigen processing and presentation	1/1053	77/7206	0.000125525887355
ko04260	Cardiac muscle contraction	29/1053	98/7206	0.000126288282147
ko05205	Proteoglycans in cancer	20/1053	271/7206	0.00029830661993
ko04540	Gap junction	34/1053	128/7206	0.000344125537399
ko05162	Measles	5/1053	120/7206	0.000359421659229
ko04064	NF-kappa B signaling pathway	3/1053	96/7206	0.000380770218672
ko05161	Hepatitis B	10/1053	173/7206	0.000422442834465
ko04610	Complement and coagulation cascades	2/1053	79/7206	0.000627304606715
ko03008	Ribosome biogenesis in eukaryotes	2/1053	79/7206	0.000627304606715
ko04110	Cell cycle	8/1053	145/7206	0.000790866260146
ko04072	Phospholipase D signaling pathway	46/1053	197/7206	0.000966744600322
ko04976	Bile secretion	23/1053	80/7206	0.00112261705971
ko05140	Leishmaniasis	2/1053	75/7206	0.0014093715994
ko04915	Estrogen signaling pathway	33/1053	131/7206	0.00157161215481
ko04014	Ras signaling pathway	60/1053	279/7206	0.00175054862917
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1053	14/7206	0.00186612025127
ko04626	Plant-pathogen interaction	8/1053	18/7206	0.00226121523809
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1053	182/7206	0.00272598362255
ko00480	Glutathione metabolism	1/1053	55/7206	0.00327123512962
ko04146	Peroxisome	4/1053	89/7206	0.00373802836972
ko04630	Jak-STAT signaling pathway	8/1053	132/7206	0.0038409766056
ko04750	Inflammatory mediator regulation of TRP channels	30/1053	122/7206	0.00401147645672
ko00590	Arachidonic acid metabolism	1/1053	52/7206	0.00485810020898
ko01524	Platinum drug resistance	3/1053	76/7206	0.00491804610507
ko04964	Proximal tubule bicarbonate reclamation	10/1053	29/7206	0.00605278398984
ko04214	Apoptosis - fly	3/1053	72/7206	0.00697940375719
ko00240	Pyrimidine metabolism	7/1053	110/7206	0.00963410405424
ko05144	Malaria	1/1053	45/7206	0.0106986015334
ko00071	Fatty acid degradation	1/1053	45/7206	0.0106986015334
ko03420	Nucleotide excision repair	1/1053	46/7206	0.0107087689017
ko05166	HTLV-I infection	28/1053	292/7206	0.011112002795
ko04668	TNF signaling pathway	8/1053	120/7206	0.0124613519539
ko04371	Apelin signaling pathway	38/1053	177/7206	0.0127629845726
ko05321	Inflammatory bowel disease (IBD)	2/1053	56/7206	0.012944047936
ko04912	GnRH signaling pathway	28/1053	122/7206	0.0133028365425
ko04210	Apoptosis	15/1053	180/7206	0.0136837634458
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1053	59/7206	0.0141359668749
ko04657	IL-17 signaling pathway	5/1053	87/7206	0.0141877500232
ko04114	Oocyte meiosis	31/1053	139/7206	0.0145979117407
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1053	15/7206	0.0147547768839
ko05145	Toxoplasmosis	9/1053	126/7206	0.0149747658761
ko04510	Focal adhesion	22/1053	240/7206	0.0152548732982
ko03022	Basal transcription factors	1/1053	44/7206	0.0162480156154
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1053	92/7206	0.0165305040366
ko03018	RNA degradation	5/1053	84/7206	0.0194312890523
ko04923	Regulation of lipolysis in adipocytes	19/1053	77/7206	0.0213856957305
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1053	100/7206	0.0220137699525
ko05418	Fluid shear stress and atherosclerosis	15/1053	173/7206	0.0221074986434
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1053	40/7206	0.0235381988297
ko05016	Huntington's disease	20/1053	215/7206	0.0238976344023
ko04062	Chemokine signaling pathway	41/1053	201/7206	0.0252380074932
ko05131	Shigellosis	5/1053	82/7206	0.0266202492198
ko00330	Arginine and proline metabolism	3/1053	61/7206	0.0279522090535
ko04330	Notch signaling pathway	3/1053	62/7206	0.0283385524641
ko04622	RIG-I-like receptor signaling pathway	3/1053	62/7206	0.0283385524641
ko05215	Prostate cancer	8/1053	111/7206	0.0289564740022
ko05206	MicroRNAs in cancer	16/1053	177/7206	0.0311552527783
ko05222	Small cell lung cancer	6/1053	89/7206	0.0335960191678
ko00982	Drug metabolism - cytochrome P450	1/1053	37/7206	0.0348271385041
ko00630	Glyoxylate and dicarboxylate metabolism	1/1053	38/7206	0.0353018698975
ko04670	Leukocyte transendothelial migration	13/1053	151/7206	0.0354540250939
ko04270	Vascular smooth muscle contraction	32/1053	154/7206	0.0370183533542
ko05219	Bladder cancer	2/1053	48/7206	0.0386818722279
ko05034	Alcoholism	46/1053	238/7206	0.0400185215341
ko05133	Pertussis	6/1053	87/7206	0.0454100176582
ko00562	Inositol phosphate metabolism	20/1053	89/7206	0.0477528205876
ko00910	Nitrogen metabolism	6/1053	19/7206	0.0478810895187
ko04350	TGF-beta signaling pathway	8/1053	103/7206	0.048562388255