ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 47/621 191/7206 1.64001460873e-11 ko04380 Osteoclast differentiation 37/621 134/7206 7.23608320634e-11 ko04650 Natural killer cell mediated cytotoxicity 29/621 97/7206 1.11879696291e-09 ko05152 Tuberculosis 40/621 187/7206 4.20343724907e-08 ko05340 Primary immunodeficiency 13/621 30/7206 3.85868279749e-07 ko05321 Inflammatory bowel disease (IBD) 18/621 56/7206 5.03829753933e-07 ko05140 Leishmaniasis 21/621 75/7206 7.69650670387e-07 ko04137 Mitophagy - animal 21/621 82/7206 3.76162517626e-06 ko05164 Influenza A 33/621 167/7206 4.46281812315e-06 ko04064 NF-kappa B signaling pathway 23/621 96/7206 4.49258120007e-06 ko05145 Toxoplasmosis 27/621 126/7206 6.63295441106e-06 ko04610 Complement and coagulation cascades 20/621 79/7206 7.72830920511e-06 ko04621 NOD-like receptor signaling pathway 31/621 157/7206 8.9974292774e-06 ko05330 Allograft rejection 10/621 24/7206 1.35259497594e-05 ko04660 T cell receptor signaling pathway 26/621 124/7206 1.48096883364e-05 ko04630 Jak-STAT signaling pathway 27/621 132/7206 2.24855704936e-05 ko05162 Measles 25/621 120/7206 2.42234603144e-05 ko04710 Circadian rhythm 13/621 43/7206 4.11030057927e-05 ko04662 B cell receptor signaling pathway 20/621 88/7206 4.27089700805e-05 ko03040 Spliceosome 1/621 145/7206 6.25771398913e-05 ko03013 RNA transport 2/621 166/7206 6.53495997707e-05 ko05144 Malaria 13/621 45/7206 6.98063187257e-05 ko04659 Th17 cell differentiation 22/621 106/7206 7.84553025107e-05 ko04620 Toll-like receptor signaling pathway 21/621 100/7206 9.50220444802e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/621 191/7206 0.000108234853765 ko04217 Necroptosis 31/621 178/7206 0.000121551494524 ko05150 Staphylococcus aureus infection 11/621 36/7206 0.00014455812417 ko04658 Th1 and Th2 cell differentiation 20/621 96/7206 0.00015563854923 ko03010 Ribosome 1/621 129/7206 0.000193192984302 ko04110 Cell cycle 2/621 145/7206 0.000441089810944 ko05332 Graft-versus-host disease 7/621 18/7206 0.000466531476466 ko04068 FoxO signaling pathway 28/621 167/7206 0.000638289861726 ko00051 Fructose and mannose metabolism 11/621 42/7206 0.00063885272591 ko05323 Rheumatoid arthritis 18/621 89/7206 0.000792817168486 ko05146 Amoebiasis 19/621 99/7206 0.000798317609714 ko00120 Primary bile acid biosynthesis 7/621 20/7206 0.000975406726553 ko04668 TNF signaling pathway 21/621 120/7206 0.00149341669725 ko04145 Phagosome 26/621 162/7206 0.0016396826936 ko04666 Fc gamma R-mediated phagocytosis 21/621 122/7206 0.0017625378071 ko04622 RIG-I-like receptor signaling pathway 13/621 62/7206 0.00202768661418 ko05310 Asthma 6/621 17/7206 0.0021634245442 ko05320 Autoimmune thyroid disease 8/621 29/7206 0.00243989282669 ko04640 Hematopoietic cell lineage 13/621 64/7206 0.00273281567263 ko04062 Chemokine signaling pathway 30/621 201/7206 0.00299260163688 ko05133 Pertussis 16/621 87/7206 0.00313624672828 ko04672 Intestinal immune network for IgA production 9/621 37/7206 0.00341324335842 ko03015 mRNA surveillance pathway 1/621 93/7206 0.00435120950154 ko05034 Alcoholism 9/621 238/7206 0.00454197584183 ko05168 Herpes simplex infection 27/621 182/7206 0.00461659265583 ko04940 Type I diabetes mellitus 8/621 32/7206 0.0047486326458 ko04066 HIF-1 signaling pathway 20/621 123/7206 0.00512833337925 ko04921 Oxytocin signaling pathway 30/621 209/7206 0.00542882124074 ko04960 Aldosterone-regulated sodium reabsorption 9/621 41/7206 0.00705147626817 ko05161 Hepatitis B 25/621 173/7206 0.00883300035164 ko04070 Phosphatidylinositol signaling system 18/621 112/7206 0.00956375908674 ko04922 Glucagon signaling pathway 20/621 128/7206 0.00973125867417 ko05142 Chagas disease (American trypanosomiasis) 20/621 130/7206 0.0104745765119 ko05132 Salmonella infection 16/621 98/7206 0.010539712393 ko04390 Hippo signaling pathway 7/621 188/7206 0.011843318518 ko04371 Apelin signaling pathway 25/621 177/7206 0.0136935995625 ko04072 Phospholipase D signaling pathway 27/621 197/7206 0.0140028719878 ko04611 Platelet activation 23/621 163/7206 0.0159771211435 ko04270 Vascular smooth muscle contraction 22/621 154/7206 0.0188376899006 ko00592 alpha-Linolenic acid metabolism 5/621 19/7206 0.0196404711497 ko00140 Steroid hormone biosynthesis 8/621 41/7206 0.0217340938219 ko04623 Cytosolic DNA-sensing pathway 8/621 41/7206 0.0217340938219 ko04930 Type II diabetes mellitus 10/621 54/7206 0.0231627611683 ko05230 Central carbon metabolism in cancer 13/621 81/7206 0.025928166213 ko04138 Autophagy - yeast 13/621 81/7206 0.025928166213 ko04022 cGMP-PKG signaling pathway 28/621 216/7206 0.0262064129171 ko04670 Leukocyte transendothelial migration 21/621 151/7206 0.0267173924985 ko05217 Basal cell carcinoma 1/621 68/7206 0.0282384043524 ko05160 Hepatitis C 21/621 153/7206 0.0285247570551 ko04113 Meiosis - yeast 1/621 70/7206 0.0290274002822 ko04120 Ubiquitin mediated proteolysis 5/621 138/7206 0.0312693006762 ko04919 Thyroid hormone signaling pathway 20/621 143/7206 0.0331131882251 ko05134 Legionellosis 12/621 74/7206 0.0332309676552 ko04014 Ras signaling pathway 34/621 279/7206 0.037900990316 ko05418 Fluid shear stress and atherosclerosis 23/621 173/7206 0.0380267635016 ko04612 Antigen processing and presentation 12/621 77/7206 0.038724381864 ko04664 Fc epsilon RI signaling pathway 12/621 77/7206 0.038724381864 ko00590 Arachidonic acid metabolism 9/621 52/7206 0.0409015175253 ko04931 Insulin resistance 19/621 137/7206 0.0434067913233 ko00950 Isoquinoline alkaloid biosynthesis 3/621 10/7206 0.0483205296067