ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 63/465 423/7206 1.51820476606e-10 ko04724 Glutamatergic synapse 30/465 152/7206 2.44793078363e-08 ko05033 Nicotine addiction 17/465 56/7206 4.0827704954e-08 ko04911 Insulin secretion 24/465 117/7206 2.99050461683e-07 ko04713 Circadian entrainment 26/465 136/7206 4.13945453204e-07 ko04710 Circadian rhythm 13/465 43/7206 1.73955323606e-06 ko04070 Phosphatidylinositol signaling system 22/465 112/7206 2.02669987079e-06 ko04020 Calcium signaling pathway 38/465 265/7206 2.49030222553e-06 ko04720 Long-term potentiation 20/465 99/7206 3.7686732052e-06 ko04726 Serotonergic synapse 24/465 137/7206 5.80752749643e-06 ko04728 Dopaminergic synapse 29/465 185/7206 1.00155800107e-05 ko05031 Amphetamine addiction 18/465 91/7206 1.5651363865e-05 ko04727 GABAergic synapse 20/465 110/7206 1.98484282405e-05 ko04971 Gastric acid secretion 18/465 98/7206 4.46967356548e-05 ko05032 Morphine addiction 19/465 110/7206 6.66509321937e-05 ko04725 Cholinergic synapse 24/465 160/7206 0.000102941417694 ko04745 Phototransduction - fly 10/465 38/7206 0.000103983164653 ko04024 cAMP signaling pathway 35/465 279/7206 0.000146174290013 ko04960 Aldosterone-regulated sodium reabsorption 10/465 41/7206 0.000206967794232 ko04360 Axon guidance 30/465 233/7206 0.000322884212529 ko04925 Aldosterone synthesis and secretion 17/465 105/7206 0.00035720928525 ko04964 Proximal tubule bicarbonate reclamation 8/465 29/7206 0.00036309262561 ko04514 Cell adhesion molecules (CAMs) 19/465 130/7206 0.000782148227212 ko03040 Spliceosome 1/465 145/7206 0.00101117760623 ko04970 Salivary secretion 15/465 95/7206 0.00102402417205 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/465 59/7206 0.00118797075209 ko00562 Inositol phosphate metabolism 14/465 89/7206 0.00154898206981 ko03013 RNA transport 2/465 166/7206 0.00204300718761 ko04723 Retrograde endocannabinoid signaling 22/465 175/7206 0.00254855581137 ko04014 Ras signaling pathway 31/465 279/7206 0.00262174942412 ko04918 Thyroid hormone synthesis 13/465 86/7206 0.00323550748375 ko04730 Long-term depression 12/465 78/7206 0.00396576257979 ko05322 Systemic lupus erythematosus 2/465 151/7206 0.00416398718441 ko04022 cGMP-PKG signaling pathway 25/465 216/7206 0.0043468038173 ko04721 Synaptic vesicle cycle 12/465 80/7206 0.00489479666158 ko04015 Rap1 signaling pathway 30/465 278/7206 0.00563472737899 ko05014 Amyotrophic lateral sclerosis (ALS) 11/465 74/7206 0.00741585391309 ko04750 Inflammatory mediator regulation of TRP channels 16/465 122/7206 0.00760287812869 ko04711 Circadian rhythm - fly 4/465 13/7206 0.00766439177507 ko04261 Adrenergic signaling in cardiomyocytes 23/465 205/7206 0.00869485821842 ko04921 Oxytocin signaling pathway 23/465 209/7206 0.00993431773714 ko04141 Protein processing in endoplasmic reticulum 4/465 184/7206 0.0138163843489 ko04919 Thyroid hormone signaling pathway 17/465 143/7206 0.014332866883 ko04742 Taste transduction 9/465 61/7206 0.0154904743752 ko04972 Pancreatic secretion 14/465 111/7206 0.0167125845891 ko04973 Carbohydrate digestion and absorption 7/465 42/7206 0.0167671912546 ko00471 D-Glutamine and D-glutamate metabolism 2/465 4/7206 0.0228488241543 ko05203 Viral carcinogenesis 9/465 277/7206 0.0241715172128 ko04924 Renin secretion 11/465 86/7206 0.024845560313 ko05164 Influenza A 4/465 167/7206 0.0251567152461 ko04626 Plant-pathogen interaction 4/465 18/7206 0.0253908732998 ko05030 Cocaine addiction 10/465 73/7206 0.0255560778727 ko04540 Gap junction 15/465 128/7206 0.0265051701572 ko04120 Ubiquitin mediated proteolysis 3/465 138/7206 0.0346779249923 ko04740 Olfactory transduction 10/465 80/7206 0.0368216234664 ko04657 IL-17 signaling pathway 1/465 87/7206 0.0440915619015