ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	43/638	56/7206	8.9195162195e-35
ko04080	Neuroactive ligand-receptor interaction	120/638	423/7206	9.36973942637e-34
ko04724	Glutamatergic synapse	69/638	152/7206	1.44239233449e-33
ko05032	Morphine addiction	46/638	110/7206	8.17859280304e-21
ko04723	Retrograde endocannabinoid signaling	58/638	175/7206	5.0299560521e-20
ko04727	GABAergic synapse	45/638	110/7206	6.38348619202e-20
ko04728	Dopaminergic synapse	56/638	185/7206	2.60381649345e-17
ko04713	Circadian entrainment	47/638	136/7206	3.06782097292e-17
ko04024	cAMP signaling pathway	65/638	279/7206	1.00302854893e-13
ko04721	Synaptic vesicle cycle	30/638	80/7206	1.69046145617e-12
ko04725	Cholinergic synapse	44/638	160/7206	3.21703391723e-12
ko04726	Serotonergic synapse	40/638	137/7206	4.02140413408e-12
ko05030	Cocaine addiction	27/638	73/7206	3.25807564244e-11
ko05014	Amyotrophic lateral sclerosis (ALS)	26/638	74/7206	2.85380098451e-10
ko05031	Amphetamine addiction	29/638	91/7206	3.89957081408e-10
ko04742	Taste transduction	23/638	61/7206	6.13033105494e-10
ko04911	Insulin secretion	32/638	117/7206	3.65843803879e-09
ko04720	Long-term potentiation	28/638	99/7206	1.57232401572e-08
ko04744	Phototransduction	15/638	36/7206	1.30694105637e-07
ko04020	Calcium signaling pathway	49/638	265/7206	4.34775484895e-07
ko04514	Cell adhesion molecules (CAMs)	30/638	130/7206	6.87050971458e-07
ko04060	Cytokine-cytokine receptor interaction	1/638	191/7206	7.85527138051e-07
ko04921	Oxytocin signaling pathway	41/638	209/7206	7.85612399346e-07
ko04261	Adrenergic signaling in cardiomyocytes	40/638	205/7206	1.23378991865e-06
ko04010	MAPK signaling pathway	54/638	321/7206	2.73714364775e-06
ko04730	Long-term depression	20/638	78/7206	9.42479918812e-06
ko05203	Viral carcinogenesis	7/638	277/7206	3.14334259918e-05
ko03040	Spliceosome	1/638	145/7206	4.0571119633e-05
ko05164	Influenza A	2/638	167/7206	4.42667728555e-05
ko04120	Ubiquitin mediated proteolysis	1/638	138/7206	5.81006263097e-05
ko04360	Axon guidance	39/638	233/7206	8.5894713918e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	18/638	79/7206	0.000139799669959
ko04740	Olfactory transduction	18/638	80/7206	0.000165823256056
ko04970	Salivary secretion	20/638	95/7206	0.000193201469012
ko05162	Measles	1/638	120/7206	0.000279873054973
ko05168	Herpes simplex infection	4/638	182/7206	0.000472278801424
ko05322	Systemic lupus erythematosus	3/638	151/7206	0.000775910993177
ko04925	Aldosterone synthesis and secretion	20/638	105/7206	0.000821282259663
ko04972	Pancreatic secretion	21/638	111/7206	0.00100097973917
ko05205	Proteoglycans in cancer	10/638	271/7206	0.00102221611364
ko04350	TGF-beta signaling pathway	1/638	103/7206	0.00133399903359
ko05166	HTLV-I infection	12/638	292/7206	0.00214921424039
ko04260	Cardiac muscle contraction	18/638	98/7206	0.00325392892134
ko04022	cGMP-PKG signaling pathway	32/638	216/7206	0.00329049239406
ko04146	Peroxisome	1/638	89/7206	0.00421838544065
ko04630	Jak-STAT signaling pathway	3/638	132/7206	0.00463713935603
ko04932	Non-alcoholic fatty liver disease (NAFLD)	6/638	182/7206	0.00504772289463
ko03013	RNA transport	5/638	166/7206	0.0051130341303
ko03018	RNA degradation	1/638	84/7206	0.00617025561516
ko04930	Type II diabetes mellitus	11/638	54/7206	0.00676941240205
ko05169	Epstein-Barr virus infection	8/638	206/7206	0.00844135100442
ko03008	Ribosome biogenesis in eukaryotes	1/638	79/7206	0.00902819080089
ko04621	NOD-like receptor signaling pathway	5/638	157/7206	0.00963503584751
ko05034	Alcoholism	33/638	238/7206	0.0100650263363
ko04540	Gap junction	20/638	128/7206	0.0111009591171
ko00564	Glycerophospholipid metabolism	2/638	99/7206	0.0113017937904
ko04964	Proximal tubule bicarbonate reclamation	7/638	29/7206	0.0114515118228
ko04141	Protein processing in endoplasmic reticulum	7/638	184/7206	0.0118298629675
ko04142	Lysosome	5/638	151/7206	0.0128542727876
ko04612	Antigen processing and presentation	1/638	77/7206	0.0135185461139
ko04218	Cellular senescence	7/638	177/7206	0.015616006921
ko04140	Autophagy - animal	6/638	164/7206	0.0169294840957
ko00240	Pyrimidine metabolism	3/638	110/7206	0.0170771445117
ko04110	Cell cycle	5/638	145/7206	0.0172162566837
ko01200	Carbon metabolism	4/638	128/7206	0.0174902523564
ko04971	Gastric acid secretion	16/638	98/7206	0.0176894501366
ko04214	Apoptosis - fly	1/638	72/7206	0.0195511453256
ko04924	Renin secretion	14/638	86/7206	0.0211614823772
ko04150	mTOR signaling pathway	8/638	184/7206	0.025169605605
ko05414	Dilated cardiomyopathy	17/638	112/7206	0.0272339687316
ko04915	Estrogen signaling pathway	19/638	131/7206	0.0287270817989
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/638	14/7206	0.0297004871754
ko04014	Ras signaling pathway	35/638	279/7206	0.0313503908757
ko04210	Apoptosis	8/638	180/7206	0.0328506114227
ko04961	Endocrine and other factor-regulated calcium reabsorption	10/638	59/7206	0.0368989767666
ko04217	Necroptosis	8/638	178/7206	0.0434668253275
ko04064	NF-kappa B signaling pathway	3/638	96/7206	0.0453243943231
ko04138	Autophagy - yeast	2/638	81/7206	0.0458496482177
ko04137	Mitophagy - animal	2/638	82/7206	0.046762185406
ko05410	Hypertrophic cardiomyopathy (HCM)	15/638	100/7206	0.0479093315231