ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	214/1274	423/7206	8.53944661393e-58
ko04724	Glutamatergic synapse	96/1274	152/7206	2.17413739409e-36
ko05033	Nicotine addiction	50/1274	56/7206	1.14219782529e-31
ko05032	Morphine addiction	74/1274	110/7206	6.37717427221e-31
ko04713	Circadian entrainment	84/1274	136/7206	6.79109594599e-31
ko04727	GABAergic synapse	71/1274	110/7206	5.41243143247e-28
ko04728	Dopaminergic synapse	92/1274	185/7206	5.27218728718e-24
ko04020	Calcium signaling pathway	113/1274	265/7206	3.57739515011e-22
ko04725	Cholinergic synapse	80/1274	160/7206	3.46087074705e-21
ko04721	Synaptic vesicle cycle	52/1274	80/7206	5.27194052029e-21
ko04024	cAMP signaling pathway	112/1274	279/7206	2.02309287448e-19
ko04723	Retrograde endocannabinoid signaling	82/1274	175/7206	2.04584580234e-19
ko04911	Insulin secretion	63/1274	117/7206	4.76433906437e-19
ko04726	Serotonergic synapse	67/1274	137/7206	2.81153173959e-17
ko04921	Oxytocin signaling pathway	86/1274	209/7206	6.36481457545e-16
ko04744	Phototransduction	28/1274	36/7206	4.63581451952e-15
ko04742	Taste transduction	38/1274	61/7206	8.7462870379e-15
ko05031	Amphetamine addiction	48/1274	91/7206	2.40093889945e-14
ko04970	Salivary secretion	49/1274	95/7206	4.06037594787e-14
ko04720	Long-term potentiation	50/1274	99/7206	6.55340526943e-14
ko04740	Olfactory transduction	42/1274	80/7206	1.26529859591e-12
ko04261	Adrenergic signaling in cardiomyocytes	77/1274	205/7206	6.21806169953e-12
ko03040	Spliceosome	1/1274	145/7206	2.62285304641e-11
ko04925	Aldosterone synthesis and secretion	46/1274	105/7206	3.37471920561e-10
ko05203	Viral carcinogenesis	16/1274	277/7206	4.34358357526e-09
ko04971	Gastric acid secretion	42/1274	98/7206	4.47884712107e-09
ko04022	cGMP-PKG signaling pathway	73/1274	216/7206	6.28141539184e-09
ko04360	Axon guidance	77/1274	233/7206	7.80534374576e-09
ko05030	Cocaine addiction	33/1274	73/7206	4.24960649273e-08
ko04540	Gap junction	47/1274	128/7206	2.32070408089e-07
ko03013	RNA transport	7/1274	166/7206	2.56010595992e-07
ko05168	Herpes simplex infection	9/1274	182/7206	3.3771220683e-07
ko05322	Systemic lupus erythematosus	6/1274	151/7206	4.23740249783e-07
ko04070	Phosphatidylinositol signaling system	42/1274	112/7206	5.17645610876e-07
ko04730	Long-term depression	32/1274	78/7206	1.25469617874e-06
ko04060	Cytokine-cytokine receptor interaction	11/1274	191/7206	1.71044934268e-06
ko04924	Renin secretion	34/1274	86/7206	2.27016160559e-06
ko05164	Influenza A	9/1274	167/7206	2.90036536569e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1274	74/7206	3.48826869324e-06
ko04972	Pancreatic secretion	40/1274	111/7206	3.51842586865e-06
ko04621	NOD-like receptor signaling pathway	8/1274	157/7206	3.75892713084e-06
ko04110	Cell cycle	7/1274	145/7206	4.74938200861e-06
ko04966	Collecting duct acid secretion	15/1274	26/7206	5.21458601096e-06
ko04750	Inflammatory mediator regulation of TRP channels	42/1274	122/7206	6.61768529058e-06
ko04141	Protein processing in endoplasmic reticulum	12/1274	184/7206	1.30153315494e-05
ko04120	Ubiquitin mediated proteolysis	7/1274	138/7206	1.40276325491e-05
ko04072	Phospholipase D signaling pathway	59/1274	197/7206	1.71221865776e-05
ko04010	MAPK signaling pathway	87/1274	321/7206	1.75426862459e-05
ko04514	Cell adhesion molecules (CAMs)	43/1274	130/7206	2.06777289173e-05
ko04745	Phototransduction - fly	18/1274	38/7206	2.36342463076e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1274	59/7206	3.67788274426e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1274	79/7206	4.46182325164e-05
ko05169	Epstein-Barr virus infection	16/1274	206/7206	5.74321988665e-05
ko04612	Antigen processing and presentation	2/1274	77/7206	6.81071409281e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1274	79/7206	7.27081587662e-05
ko05414	Dilated cardiomyopathy	37/1274	112/7206	8.02744722917e-05
ko04976	Bile secretion	29/1274	80/7206	8.03590025099e-05
ko05110	Vibrio cholerae infection	24/1274	63/7206	0.000160514580178
ko05162	Measles	7/1274	120/7206	0.000238333874698
ko04260	Cardiac muscle contraction	32/1274	98/7206	0.000269568781698
ko04014	Ras signaling pathway	73/1274	279/7206	0.00029619250197
ko04146	Peroxisome	4/1274	89/7206	0.000369919064213
ko04923	Regulation of lipolysis in adipocytes	26/1274	77/7206	0.000733169180757
ko05205	Proteoglycans in cancer	28/1274	271/7206	0.000829188380714
ko04371	Apelin signaling pathway	49/1274	177/7206	0.000902794457499
ko04922	Glucagon signaling pathway	38/1274	128/7206	0.000923438021569
ko04915	Estrogen signaling pathway	38/1274	131/7206	0.00113986509633
ko04330	Notch signaling pathway	2/1274	62/7206	0.00115274520645
ko04626	Plant-pathogen interaction	9/1274	18/7206	0.00172374299194
ko04064	NF-kappa B signaling pathway	6/1274	96/7206	0.00173010877854
ko00240	Pyrimidine metabolism	8/1274	110/7206	0.00233179823346
ko04912	GnRH signaling pathway	35/1274	122/7206	0.00252699983225
ko00071	Fatty acid degradation	1/1274	45/7206	0.00273024841756
ko03420	Nucleotide excision repair	1/1274	46/7206	0.00282304476184
ko05166	HTLV-I infection	33/1274	292/7206	0.00283644618532
ko00310	Lysine degradation	4/1274	73/7206	0.00319047007701
ko05140	Leishmaniasis	4/1274	75/7206	0.00330207863908
ko05131	Shigellosis	5/1274	82/7206	0.00332055720453
ko00520	Amino sugar and nucleotide sugar metabolism	2/1274	55/7206	0.00374183452217
ko04622	RIG-I-like receptor signaling pathway	3/1274	62/7206	0.0042098606235
ko03022	Basal transcription factors	1/1274	44/7206	0.00435775303212
ko05161	Hepatitis B	17/1274	173/7206	0.0045989526883
ko04610	Complement and coagulation cascades	5/1274	79/7206	0.00467336006726
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1274	100/7206	0.00510927745441
ko04270	Vascular smooth muscle contraction	41/1274	154/7206	0.00522621512219
ko00590	Arachidonic acid metabolism	2/1274	52/7206	0.00537855250334
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1274	14/7206	0.00573346565654
ko05145	Toxoplasmosis	11/1274	126/7206	0.00637955694416
ko04657	IL-17 signaling pathway	6/1274	87/7206	0.0065720207245
ko00562	Inositol phosphate metabolism	26/1274	89/7206	0.00725658530982
ko04710	Circadian rhythm	15/1274	43/7206	0.00744707510592
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1274	182/7206	0.00773580778426
ko03018	RNA degradation	6/1274	84/7206	0.00893153778124
ko00630	Glyoxylate and dicarboxylate metabolism	1/1274	38/7206	0.00939505424473
ko04918	Thyroid hormone synthesis	25/1274	86/7206	0.00963667669016
ko04015	Rap1 signaling pathway	66/1274	278/7206	0.0100503125275
ko05016	Huntington's disease	24/1274	215/7206	0.0107301436457
ko04964	Proximal tubule bicarbonate reclamation	11/1274	29/7206	0.0113075676615
ko00480	Glutathione metabolism	3/1274	55/7206	0.0124710559741
ko04217	Necroptosis	19/1274	178/7206	0.0125008246884
ko04214	Apoptosis - fly	5/1274	72/7206	0.0126095130198
ko05321	Inflammatory bowel disease (IBD)	3/1274	56/7206	0.0126173952346
ko04115	p53 signaling pathway	5/1274	74/7206	0.0130933166109
ko04973	Carbohydrate digestion and absorption	14/1274	42/7206	0.0132757394658
ko04658	Th1 and Th2 cell differentiation	8/1274	96/7206	0.0145715561045
ko04630	Jak-STAT signaling pathway	13/1274	132/7206	0.0152870277037
ko05133	Pertussis	7/1274	87/7206	0.0155965393347
ko05144	Malaria	2/1274	45/7206	0.0169480811719
ko04210	Apoptosis	20/1274	180/7206	0.0174151922602
ko00330	Arginine and proline metabolism	4/1274	61/7206	0.0179149956166
ko00280	Valine, leucine and isoleucine degradation	3/1274	54/7206	0.0182302086144
ko04916	Melanogenesis	36/1274	142/7206	0.0193530928623
ko05231	Choline metabolism in cancer	34/1274	134/7206	0.0221141218775
ko01524	Platinum drug resistance	6/1274	76/7206	0.0226147387157
ko05132	Salmonella infection	9/1274	98/7206	0.0233104672044
ko04620	Toll-like receptor signaling pathway	9/1274	100/7206	0.0237698735052
ko04960	Aldosterone-regulated sodium reabsorption	13/1274	41/7206	0.0239994213954
ko05217	Basal cell carcinoma	5/1274	68/7206	0.0241633093248
ko05214	Glioma	22/1274	79/7206	0.0248825778892
ko05215	Prostate cancer	11/1274	111/7206	0.0321795262526
ko05418	Fluid shear stress and atherosclerosis	20/1274	173/7206	0.0336905934144
ko05219	Bladder cancer	3/1274	48/7206	0.0358184079598
ko04350	TGF-beta signaling pathway	10/1274	103/7206	0.0362765168119
ko04142	Lysosome	17/1274	151/7206	0.0398211596973
ko04113	Meiosis - yeast	6/1274	70/7206	0.0412778981717
ko04114	Oocyte meiosis	34/1274	139/7206	0.0425338164042
ko04640	Hematopoietic cell lineage	5/1274	64/7206	0.0460967218455