ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	166/1013	423/7206	2.13960165508e-40
ko04724	Glutamatergic synapse	79/1013	152/7206	4.15045517027e-29
ko05033	Nicotine addiction	43/1013	56/7206	3.13989704708e-26
ko05032	Morphine addiction	58/1013	110/7206	4.92011663097e-22
ko04728	Dopaminergic synapse	79/1013	185/7206	5.00342032117e-22
ko04721	Synaptic vesicle cycle	48/1013	80/7206	1.11361612982e-21
ko04713	Circadian entrainment	63/1013	136/7206	5.39854380437e-20
ko04725	Cholinergic synapse	68/1013	160/7206	5.85390355082e-19
ko04727	GABAergic synapse	53/1013	110/7206	6.01098177472e-18
ko04723	Retrograde endocannabinoid signaling	67/1013	175/7206	6.94594032552e-16
ko04024	cAMP signaling pathway	89/1013	279/7206	9.32123592912e-15
ko04020	Calcium signaling pathway	85/1013	265/7206	1.93739527724e-14
ko04911	Insulin secretion	49/1013	117/7206	1.08660023422e-13
ko05031	Amphetamine addiction	41/1013	91/7206	6.21357193117e-13
ko04720	Long-term potentiation	42/1013	99/7206	3.84584920812e-12
ko04726	Serotonergic synapse	51/1013	137/7206	7.79168337801e-12
ko04921	Oxytocin signaling pathway	67/1013	209/7206	1.9445476443e-11
ko04742	Taste transduction	30/1013	61/7206	5.35554107087e-11
ko04925	Aldosterone synthesis and secretion	37/1013	105/7206	3.34288102708e-08
ko04744	Phototransduction	19/1013	36/7206	4.40345772446e-08
ko03040	Spliceosome	2/1013	145/7206	1.65101680509e-07
ko04261	Adrenergic signaling in cardiomyocytes	57/1013	205/7206	1.90937709689e-07
ko04970	Salivary secretion	33/1013	95/7206	2.71934451055e-07
ko05030	Cocaine addiction	27/1013	73/7206	8.02107862253e-07
ko04745	Phototransduction - fly	18/1013	38/7206	8.21960620638e-07
ko04971	Gastric acid secretion	33/1013	98/7206	9.38605948898e-07
ko04730	Long-term depression	28/1013	78/7206	1.01876249228e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1013	74/7206	1.0965474199e-06
ko04966	Collecting duct acid secretion	14/1013	26/7206	1.99895780936e-06
ko04514	Cell adhesion molecules (CAMs)	38/1013	130/7206	5.30778894297e-06
ko04070	Phosphatidylinositol signaling system	34/1013	112/7206	6.71306684597e-06
ko05168	Herpes simplex infection	7/1013	182/7206	7.03067768474e-06
ko04360	Axon guidance	58/1013	233/7206	7.97214553947e-06
ko05322	Systemic lupus erythematosus	5/1013	151/7206	1.50132469547e-05
ko04010	MAPK signaling pathway	73/1013	321/7206	1.67786954217e-05
ko05164	Influenza A	7/1013	167/7206	4.01107408664e-05
ko04972	Pancreatic secretion	32/1013	111/7206	4.38053400753e-05
ko03013	RNA transport	7/1013	166/7206	5.88150911552e-05
ko04740	Olfactory transduction	25/1013	80/7206	6.41859952443e-05
ko05203	Viral carcinogenesis	18/1013	277/7206	9.17354574455e-05
ko04022	cGMP-PKG signaling pathway	51/1013	216/7206	0.000135448526864
ko04621	NOD-like receptor signaling pathway	7/1013	157/7206	0.000162553898661
ko04750	Inflammatory mediator regulation of TRP channels	33/1013	122/7206	0.000174639153649
ko04612	Antigen processing and presentation	1/1013	77/7206	0.000197041800471
ko04141	Protein processing in endoplasmic reticulum	10/1013	184/7206	0.000229976898892
ko04120	Ubiquitin mediated proteolysis	6/1013	138/7206	0.000287396618348
ko04060	Cytokine-cytokine receptor interaction	11/1013	191/7206	0.00030811361279
ko05110	Vibrio cholerae infection	20/1013	63/7206	0.000319474325918
ko05169	Epstein-Barr virus infection	13/1013	206/7206	0.000513798684821
ko04014	Ras signaling pathway	60/1013	279/7206	0.000565461513685
ko05162	Measles	5/1013	120/7206	0.000768957110805
ko04540	Gap junction	32/1013	128/7206	0.000777672403467
ko03008	Ribosome biogenesis in eukaryotes	2/1013	79/7206	0.000954713813166
ko04964	Proximal tubule bicarbonate reclamation	11/1013	29/7206	0.00122451234696
ko04110	Cell cycle	8/1013	145/7206	0.00153548883868
ko04924	Renin secretion	23/1013	86/7206	0.00159653337308
ko04626	Plant-pathogen interaction	8/1013	18/7206	0.001751487827
ko04630	Jak-STAT signaling pathway	7/1013	132/7206	0.0021552318065
ko04064	NF-kappa B signaling pathway	4/1013	96/7206	0.00274094654311
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1013	59/7206	0.00372534203837
ko04072	Phospholipase D signaling pathway	42/1013	197/7206	0.00477500082119
ko04915	Estrogen signaling pathway	30/1013	131/7206	0.00512677673552
ko05161	Hepatitis B	12/1013	173/7206	0.0052880784179
ko04146	Peroxisome	4/1013	89/7206	0.00538880099348
ko05140	Leishmaniasis	3/1013	75/7206	0.00714394417357
ko05166	HTLV-I infection	26/1013	292/7206	0.00767727831263
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	20/1013	79/7206	0.0080974733591
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1013	14/7206	0.00832877776448
ko04114	Oocyte meiosis	31/1013	139/7206	0.00902487033293
ko05145	Toxoplasmosis	8/1013	126/7206	0.00929261058607
ko04960	Aldosterone-regulated sodium reabsorption	12/1013	41/7206	0.0106909469128
ko04710	Circadian rhythm	12/1013	43/7206	0.0144332640999
ko03022	Basal transcription factors	1/1013	44/7206	0.0161951622226
ko05144	Malaria	1/1013	45/7206	0.0162767618461
ko00071	Fatty acid degradation	1/1013	45/7206	0.0162767618461
ko03420	Nucleotide excision repair	1/1013	46/7206	0.0167489415285
ko05205	Proteoglycans in cancer	25/1013	271/7206	0.0201304651909
ko04610	Complement and coagulation cascades	4/1013	79/7206	0.021010560587
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1013	92/7206	0.0222516122606
ko04260	Cardiac muscle contraction	22/1013	98/7206	0.0266128487518
ko00590	Arachidonic acid metabolism	2/1013	52/7206	0.0273674450804
ko00280	Valine, leucine and isoleucine degradation	2/1013	54/7206	0.0280898223375
ko04922	Glucagon signaling pathway	27/1013	128/7206	0.0282051442423
ko04510	Focal adhesion	22/1013	240/7206	0.0292296291144
ko05231	Choline metabolism in cancer	28/1013	134/7206	0.0317632101421
ko05214	Glioma	18/1013	79/7206	0.0330475959094
ko03410	Base excision repair	1/1013	38/7206	0.0354433621671
ko00240	Pyrimidine metabolism	8/1013	110/7206	0.0376806511042
ko00330	Arginine and proline metabolism	3/1013	61/7206	0.0400182057773
ko00910	Nitrogen metabolism	6/1013	19/7206	0.040575941075
ko04622	RIG-I-like receptor signaling pathway	3/1013	62/7206	0.0408580385551
ko05418	Fluid shear stress and atherosclerosis	15/1013	173/7206	0.0452778032577
ko05222	Small cell lung cancer	6/1013	89/7206	0.0454381487922
ko04930	Type II diabetes mellitus	13/1013	54/7206	0.0465075496856
ko00680	Methane metabolism	9/1013	34/7206	0.0465441255478
ko04912	GnRH signaling pathway	25/1013	122/7206	0.0477927487537
ko04217	Necroptosis	16/1013	178/7206	0.0491432426904