ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	65/550	152/7206	1.08689988553e-33
ko05033	Nicotine addiction	40/550	56/7206	6.94760760685e-33
ko04080	Neuroactive ligand-receptor interaction	99/550	423/7206	7.55508053623e-26
ko05032	Morphine addiction	47/550	110/7206	1.60824688752e-24
ko04727	GABAergic synapse	45/550	110/7206	1.44010810914e-22
ko04723	Retrograde endocannabinoid signaling	57/550	175/7206	1.79494404507e-22
ko04713	Circadian entrainment	46/550	136/7206	4.70343296736e-19
ko04728	Dopaminergic synapse	54/550	185/7206	7.31179869842e-19
ko04024	cAMP signaling pathway	60/550	279/7206	5.36045117989e-14
ko04721	Synaptic vesicle cycle	29/550	80/7206	2.51105989626e-13
ko04911	Insulin secretion	34/550	117/7206	3.20510009441e-12
ko05030	Cocaine addiction	26/550	73/7206	7.11543812322e-12
ko04725	Cholinergic synapse	39/550	160/7206	3.3102460096e-11
ko05031	Amphetamine addiction	28/550	91/7206	6.15864033703e-11
ko04720	Long-term potentiation	29/550	99/7206	1.06086298839e-10
ko04020	Calcium signaling pathway	52/550	265/7206	1.12321481907e-10
ko04921	Oxytocin signaling pathway	44/550	209/7206	3.16848625155e-10
ko04742	Taste transduction	21/550	61/7206	1.58993172617e-09
ko04726	Serotonergic synapse	32/550	137/7206	6.34338823272e-09
ko04261	Adrenergic signaling in cardiomyocytes	40/550	205/7206	2.08415621618e-08
ko04010	MAPK signaling pathway	52/550	321/7206	1.3008976245e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	19/550	74/7206	1.74188516404e-06
ko04730	Long-term depression	19/550	78/7206	4.08760594006e-06
ko05203	Viral carcinogenesis	4/550	277/7206	4.72704848513e-06
ko04970	Salivary secretion	21/550	95/7206	6.75742126075e-06
ko04072	Phospholipase D signaling pathway	34/550	197/7206	6.9388790213e-06
ko04514	Cell adhesion molecules (CAMs)	25/550	130/7206	1.28083844388e-05
ko04972	Pancreatic secretion	22/550	111/7206	2.59118471914e-05
ko04925	Aldosterone synthesis and secretion	21/550	105/7206	3.42204174876e-05
ko04360	Axon guidance	36/550	233/7206	4.16169938726e-05
ko04915	Estrogen signaling pathway	24/550	131/7206	7.13955581655e-05
ko05414	Dilated cardiomyopathy	21/550	112/7206	9.23150186121e-05
ko03040	Spliceosome	1/550	145/7206	0.000204037544376
ko04110	Cell cycle	1/550	145/7206	0.000204037544376
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	16/550	79/7206	0.00024939506503
ko04260	Cardiac muscle contraction	18/550	98/7206	0.000376570062159
ko04060	Cytokine-cytokine receptor interaction	3/550	191/7206	0.00042851187051
ko04930	Type II diabetes mellitus	12/550	54/7206	0.000608888341784
ko04621	NOD-like receptor signaling pathway	2/550	157/7206	0.000656920996926
ko05169	Epstein-Barr virus infection	4/550	206/7206	0.000711229359874
ko05231	Choline metabolism in cancer	21/550	134/7206	0.00142059684806
ko04022	cGMP-PKG signaling pathway	30/550	216/7206	0.00153009890896
ko03013	RNA transport	3/550	166/7206	0.00165642340262
ko05164	Influenza A	3/550	167/7206	0.00166977230631
ko04540	Gap junction	20/550	128/7206	0.00197156738844
ko05168	Herpes simplex infection	4/550	182/7206	0.00262857448083
ko04141	Protein processing in endoplasmic reticulum	4/550	184/7206	0.00270689541564
ko00240	Pyrimidine metabolism	1/550	110/7206	0.0030845529336
ko04971	Gastric acid secretion	16/550	98/7206	0.00322695765206
ko05410	Hypertrophic cardiomyopathy (HCM)	16/550	100/7206	0.0038254522562
ko01200	Carbon metabolism	2/550	128/7206	0.00399279594833
ko04350	TGF-beta signaling pathway	1/550	103/7206	0.00442693982103
ko04666	Fc gamma R-mediated phagocytosis	18/550	122/7206	0.00557212014487
ko04070	Phosphatidylinositol signaling system	17/550	112/7206	0.00596147004059
ko05162	Measles	2/550	120/7206	0.00825017976986
ko04120	Ubiquitin mediated proteolysis	3/550	138/7206	0.00910407585063
ko04015	Rap1 signaling pathway	33/550	278/7206	0.0106971132235
ko04014	Ras signaling pathway	33/550	279/7206	0.0109058493366
ko05034	Alcoholism	29/550	238/7206	0.01224298472
ko04630	Jak-STAT signaling pathway	3/550	132/7206	0.0127022378
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/550	14/7206	0.0181290562481
ko05322	Systemic lupus erythematosus	4/550	151/7206	0.018589498755
ko05205	Proteoglycans in cancer	11/550	271/7206	0.0196229740617
ko03018	RNA degradation	1/550	84/7206	0.0204255483612
ko01230	Biosynthesis of amino acids	1/550	85/7206	0.0208406030449
ko04924	Renin secretion	13/550	86/7206	0.0213816073171
ko04932	Non-alcoholic fatty liver disease (NAFLD)	6/550	182/7206	0.022759774163
ko03008	Ribosome biogenesis in eukaryotes	1/550	79/7206	0.0297717510781
ko04217	Necroptosis	6/550	178/7206	0.0305499939369
ko04064	NF-kappa B signaling pathway	2/550	96/7206	0.0326831949714
ko04750	Inflammatory mediator regulation of TRP channels	16/550	122/7206	0.0362070766385
ko00515	Mannose type O-glycan biosynthesis	5/550	25/7206	0.037710211758
ko00310	Lysine degradation	1/550	73/7206	0.0426002403801
ko00010	Glycolysis / Gluconeogenesis	1/550	74/7206	0.0433157940927
ko05215	Prostate cancer	3/550	111/7206	0.0464707890154
ko04144	Endocytosis	36/550	342/7206	0.0466689817253