ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	210/1239	423/7206	4.3642428375e-57
ko04724	Glutamatergic synapse	91/1239	152/7206	7.13169598122e-33
ko05033	Nicotine addiction	50/1239	56/7206	2.85553837309e-32
ko05032	Morphine addiction	70/1239	110/7206	8.01822160841e-28
ko04727	GABAergic synapse	69/1239	110/7206	6.97003339216e-27
ko04713	Circadian entrainment	77/1239	136/7206	1.00709103495e-25
ko04721	Synaptic vesicle cycle	53/1239	80/7206	1.48057298677e-22
ko04728	Dopaminergic synapse	87/1239	185/7206	1.64084318454e-21
ko04725	Cholinergic synapse	78/1239	160/7206	1.36744061295e-20
ko04020	Calcium signaling pathway	105/1239	265/7206	1.03065462825e-18
ko04024	cAMP signaling pathway	108/1239	279/7206	2.36458360284e-18
ko04723	Retrograde endocannabinoid signaling	79/1239	175/7206	2.72955527273e-18
ko04742	Taste transduction	39/1239	61/7206	4.01933912483e-16
ko04911	Insulin secretion	58/1239	117/7206	4.97407787777e-16
ko04726	Serotonergic synapse	61/1239	137/7206	4.73378241401e-14
ko04744	Phototransduction	26/1239	36/7206	4.56346439355e-13
ko04921	Oxytocin signaling pathway	79/1239	209/7206	5.1463096933e-13
ko04261	Adrenergic signaling in cardiomyocytes	77/1239	205/7206	1.45029142208e-12
ko04720	Long-term potentiation	46/1239	99/7206	1.04602552182e-11
ko05031	Amphetamine addiction	43/1239	91/7206	2.48940558902e-11
ko04360	Axon guidance	81/1239	233/7206	4.21984439294e-11
ko03040	Spliceosome	1/1239	145/7206	4.41089804463e-11
ko04740	Olfactory transduction	39/1239	80/7206	6.44810470953e-11
ko04970	Salivary secretion	43/1239	95/7206	1.43508471802e-10
ko05203	Viral carcinogenesis	16/1239	277/7206	1.32650423756e-08
ko05030	Cocaine addiction	32/1239	73/7206	8.4378668944e-08
ko04925	Aldosterone synthesis and secretion	41/1239	105/7206	1.22195749116e-07
ko04022	cGMP-PKG signaling pathway	68/1239	216/7206	1.85782228831e-07
ko05168	Herpes simplex infection	8/1239	182/7206	2.25181478537e-07
ko04060	Cytokine-cytokine receptor interaction	9/1239	191/7206	2.60616609916e-07
ko03013	RNA transport	7/1239	166/7206	3.84509816926e-07
ko04971	Gastric acid secretion	38/1239	98/7206	4.47039835861e-07
ko04540	Gap junction	45/1239	128/7206	7.09254959493e-07
ko05322	Systemic lupus erythematosus	6/1239	151/7206	9.77026072216e-07
ko05164	Influenza A	8/1239	167/7206	1.98457725434e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1239	74/7206	2.43151066193e-06
ko04924	Renin secretion	33/1239	86/7206	3.70749947218e-06
ko04010	MAPK signaling pathway	87/1239	321/7206	4.96538085258e-06
ko04120	Ubiquitin mediated proteolysis	6/1239	138/7206	6.22162889197e-06
ko04141	Protein processing in endoplasmic reticulum	11/1239	184/7206	9.95770427053e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1239	59/7206	1.66500162296e-05
ko04070	Phosphatidylinositol signaling system	38/1239	112/7206	2.01057753348e-05
ko04966	Collecting duct acid secretion	14/1239	26/7206	2.26756864709e-05
ko04972	Pancreatic secretion	37/1239	111/7206	3.37903122774e-05
ko04514	Cell adhesion molecules (CAMs)	41/1239	130/7206	5.13686334907e-05
ko04730	Long-term depression	28/1239	78/7206	5.92024071929e-05
ko04260	Cardiac muscle contraction	33/1239	98/7206	6.57201954604e-05
ko05110	Vibrio cholerae infection	24/1239	63/7206	6.63244618756e-05
ko04745	Phototransduction - fly	17/1239	38/7206	6.82741657292e-05
ko04610	Complement and coagulation cascades	2/1239	79/7206	7.1324482122e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1239	79/7206	7.1324482122e-05
ko04621	NOD-like receptor signaling pathway	10/1239	157/7206	9.6760988388e-05
ko04612	Antigen processing and presentation	2/1239	77/7206	0.000106319020651
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1239	79/7206	0.000115826151683
ko04976	Bile secretion	28/1239	80/7206	0.00012844247757
ko04014	Ras signaling pathway	73/1239	279/7206	0.000128610075696
ko05140	Leishmaniasis	2/1239	75/7206	0.000159408456216
ko05414	Dilated cardiomyopathy	35/1239	112/7206	0.000213573639277
ko05169	Epstein-Barr virus infection	17/1239	206/7206	0.000241247223602
ko04072	Phospholipase D signaling pathway	54/1239	197/7206	0.000254684806256
ko04750	Inflammatory mediator regulation of TRP channels	37/1239	122/7206	0.00036750299174
ko04110	Cell cycle	10/1239	145/7206	0.000488001312154
ko04146	Peroxisome	4/1239	89/7206	0.000553445143365
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1239	14/7206	0.000842016199417
ko04064	NF-kappa B signaling pathway	5/1239	96/7206	0.000893047726993
ko05205	Proteoglycans in cancer	27/1239	271/7206	0.000966492881326
ko04923	Regulation of lipolysis in adipocytes	25/1239	77/7206	0.00113373369037
ko04640	Hematopoietic cell lineage	2/1239	64/7206	0.00120739303602
ko00240	Pyrimidine metabolism	7/1239	110/7206	0.00129028415892
ko05162	Measles	8/1239	120/7206	0.0013216337899
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1239	182/7206	0.00139199757909
ko00330	Arginine and proline metabolism	2/1239	61/7206	0.00173803129604
ko04964	Proximal tubule bicarbonate reclamation	12/1239	29/7206	0.00185389931203
ko00260	Glycine, serine and threonine metabolism	1/1239	48/7206	0.00186163266977
ko04657	IL-17 signaling pathway	5/1239	87/7206	0.00242589245109
ko03420	Nucleotide excision repair	1/1239	46/7206	0.00280195496871
ko04915	Estrogen signaling pathway	36/1239	131/7206	0.00319377521853
ko04371	Apelin signaling pathway	46/1239	177/7206	0.00322457888351
ko03018	RNA degradation	5/1239	84/7206	0.00340923183285
ko00480	Glutathione metabolism	2/1239	55/7206	0.00371408658228
ko05321	Inflammatory bowel disease (IBD)	2/1239	56/7206	0.00376101285028
ko05161	Hepatitis B	16/1239	173/7206	0.00406778650512
ko03022	Basal transcription factors	1/1239	44/7206	0.0042419547154
ko05144	Malaria	1/1239	45/7206	0.00440657860468
ko00071	Fatty acid degradation	1/1239	45/7206	0.00440657860468
ko05131	Shigellosis	5/1239	82/7206	0.00477877681916
ko04622	RIG-I-like receptor signaling pathway	3/1239	62/7206	0.00621390708138
ko04214	Apoptosis - fly	4/1239	72/7206	0.00677165584272
ko00380	Tryptophan metabolism	2/1239	50/7206	0.00800102086458
ko00590	Arachidonic acid metabolism	2/1239	52/7206	0.00840676017512
ko04658	Th1 and Th2 cell differentiation	7/1239	96/7206	0.00892602979595
ko05133	Pertussis	6/1239	87/7206	0.00926545718075
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1239	40/7206	0.00987592071162
ko04620	Toll-like receptor signaling pathway	8/1239	100/7206	0.0109744767208
ko04115	p53 signaling pathway	5/1239	74/7206	0.0128571391994
ko00982	Drug metabolism - cytochrome P450	1/1239	37/7206	0.0145058856425
ko00630	Glyoxylate and dicarboxylate metabolism	1/1239	38/7206	0.0151609515501
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1239	100/7206	0.0153409647384
ko01200	Carbon metabolism	12/1239	128/7206	0.0174604651388
ko00310	Lysine degradation	5/1239	73/7206	0.0180872914582
ko00280	Valine, leucine and isoleucine degradation	3/1239	54/7206	0.0181188116135
ko04015	Rap1 signaling pathway	63/1239	278/7206	0.0183974065417
ko04912	GnRH signaling pathway	31/1239	122/7206	0.0208118292151
ko00562	Inositol phosphate metabolism	24/1239	89/7206	0.02244799893
ko05145	Toxoplasmosis	12/1239	126/7206	0.0227928852726
ko04916	Melanogenesis	35/1239	142/7206	0.0239487995155
ko04626	Plant-pathogen interaction	7/1239	18/7206	0.024081691353
ko05231	Choline metabolism in cancer	33/1239	134/7206	0.0274636208068
ko04210	Apoptosis	20/1239	180/7206	0.0275092539572
ko04918	Thyroid hormone synthesis	23/1239	86/7206	0.0295734950153
ko05132	Salmonella infection	9/1239	98/7206	0.0311361769554
ko01524	Platinum drug resistance	6/1239	76/7206	0.0312267106927
ko05418	Fluid shear stress and atherosclerosis	19/1239	173/7206	0.0315292881675
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1239	26/7206	0.0319361530158
ko04217	Necroptosis	20/1239	178/7206	0.0341748063447
ko00140	Steroid hormone biosynthesis	2/1239	41/7206	0.0359821447702
ko00983	Drug metabolism - other enzymes	2/1239	42/7206	0.0371131650987
ko04668	TNF signaling pathway	12/1239	120/7206	0.0372657032839
ko05166	HTLV-I infection	37/1239	292/7206	0.0391784311314
ko05215	Prostate cancer	11/1239	111/7206	0.0418614372057
ko04930	Type II diabetes mellitus	15/1239	54/7206	0.0459657573134
ko04630	Jak-STAT signaling pathway	14/1239	132/7206	0.0469788887944
ko05320	Autoimmune thyroid disease	1/1239	29/7206	0.0480354697901
ko04142	Lysosome	17/1239	151/7206	0.0499288263959