ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1166	423/7206	1.42731737721e-51
ko05033	Nicotine addiction	50/1166	56/7206	1.38150388551e-33
ko04724	Glutamatergic synapse	89/1166	152/7206	3.10265436559e-33
ko05032	Morphine addiction	68/1166	110/7206	1.37488563849e-27
ko04727	GABAergic synapse	67/1166	110/7206	1.19255132568e-26
ko04713	Circadian entrainment	74/1166	136/7206	5.27999753429e-25
ko04721	Synaptic vesicle cycle	51/1166	80/7206	7.60018617999e-22
ko04728	Dopaminergic synapse	84/1166	185/7206	2.39085635683e-21
ko04725	Cholinergic synapse	75/1166	160/7206	3.51098630927e-20
ko04723	Retrograde endocannabinoid signaling	78/1166	175/7206	2.71911927134e-19
ko04024	cAMP signaling pathway	101/1166	279/7206	8.82161169838e-17
ko04911	Insulin secretion	55/1166	117/7206	3.56108106839e-15
ko04020	Calcium signaling pathway	94/1166	265/7206	5.32077279703e-15
ko04744	Phototransduction	27/1166	36/7206	7.20500564533e-15
ko04742	Taste transduction	36/1166	61/7206	2.89952792946e-14
ko04726	Serotonergic synapse	58/1166	137/7206	1.91849736009e-13
ko04921	Oxytocin signaling pathway	74/1166	209/7206	5.503681705e-12
ko05031	Amphetamine addiction	42/1166	91/7206	1.45462614232e-11
ko04720	Long-term potentiation	44/1166	99/7206	2.3070356796e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1166	205/7206	5.6846806751e-11
ko03040	Spliceosome	1/1166	145/7206	3.16178661404e-10
ko05030	Cocaine addiction	31/1166	73/7206	7.77744857281e-08
ko04925	Aldosterone synthesis and secretion	39/1166	105/7206	1.44384046343e-07
ko04360	Axon guidance	69/1166	233/7206	1.68266012513e-07
ko05203	Viral carcinogenesis	16/1166	277/7206	1.69086311557e-07
ko05168	Herpes simplex infection	7/1166	182/7206	2.09012798862e-07
ko04970	Salivary secretion	36/1166	95/7206	2.78025416261e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1166	74/7206	4.29821411969e-07
ko04971	Gastric acid secretion	36/1166	98/7206	5.9360388307e-07
ko04740	Olfactory transduction	31/1166	80/7206	9.02635054562e-07
ko04966	Collecting duct acid secretion	15/1166	26/7206	1.64407138421e-06
ko03013	RNA transport	7/1166	166/7206	1.90349126151e-06
ko05322	Systemic lupus erythematosus	6/1166	151/7206	3.35167245551e-06
ko04060	Cytokine-cytokine receptor interaction	10/1166	191/7206	5.36697413201e-06
ko05164	Influenza A	8/1166	167/7206	9.2947679744e-06
ko04141	Protein processing in endoplasmic reticulum	10/1166	184/7206	1.02849778064e-05
ko04010	MAPK signaling pathway	82/1166	321/7206	1.20029207909e-05
ko04610	Complement and coagulation cascades	1/1166	79/7206	2.04947349201e-05
ko04972	Pancreatic secretion	36/1166	111/7206	2.06739804536e-05
ko04070	Phosphatidylinositol signaling system	36/1166	112/7206	2.38275822295e-05
ko04621	NOD-like receptor signaling pathway	8/1166	157/7206	2.54530221799e-05
ko04022	cGMP-PKG signaling pathway	59/1166	216/7206	2.96829290185e-05
ko04745	Phototransduction - fly	17/1166	38/7206	3.05489122418e-05
ko04514	Cell adhesion molecules (CAMs)	40/1166	130/7206	3.08834222677e-05
ko04072	Phospholipase D signaling pathway	54/1166	197/7206	4.87954937817e-05
ko05169	Epstein-Barr virus infection	14/1166	206/7206	7.09019268233e-05
ko05110	Vibrio cholerae infection	23/1166	63/7206	8.34428102762e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1166	79/7206	0.000172656326145
ko05162	Measles	6/1166	120/7206	0.000245981942464
ko05205	Proteoglycans in cancer	23/1166	271/7206	0.000272036202317
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1166	79/7206	0.000285225386511
ko04014	Ras signaling pathway	68/1166	279/7206	0.000334256351847
ko05161	Hepatitis B	12/1166	173/7206	0.000348243740818
ko04110	Cell cycle	9/1166	145/7206	0.000375742832921
ko05140	Leishmaniasis	2/1166	75/7206	0.000387460864271
ko05414	Dilated cardiomyopathy	33/1166	112/7206	0.000388995959011
ko04064	NF-kappa B signaling pathway	4/1166	96/7206	0.000404912890374
ko04730	Long-term depression	25/1166	78/7206	0.000497738663252
ko04924	Renin secretion	27/1166	86/7206	0.00053416804745
ko04260	Cardiac muscle contraction	29/1166	98/7206	0.000771460887561
ko04626	Plant-pathogen interaction	9/1166	18/7206	0.000891622568127
ko00240	Pyrimidine metabolism	6/1166	110/7206	0.000967796802599
ko04915	Estrogen signaling pathway	36/1166	131/7206	0.00106360435994
ko04540	Gap junction	35/1166	128/7206	0.00143655723893
ko04612	Antigen processing and presentation	3/1166	77/7206	0.00153787115668
ko00590	Arachidonic acid metabolism	1/1166	52/7206	0.00198324550685
ko04120	Ubiquitin mediated proteolysis	10/1166	138/7206	0.0023155499409
ko04923	Regulation of lipolysis in adipocytes	23/1166	77/7206	0.00261591337911
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1166	14/7206	0.00342225840471
ko04750	Inflammatory mediator regulation of TRP channels	32/1166	122/7206	0.00407233576937
ko03420	Nucleotide excision repair	1/1166	46/7206	0.00445501073442
ko04976	Bile secretion	23/1166	80/7206	0.00523917712944
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/1166	15/7206	0.00552995842268
ko05321	Inflammatory bowel disease (IBD)	2/1166	56/7206	0.00572742020125
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1166	59/7206	0.00654086241744
ko03022	Basal transcription factors	1/1166	44/7206	0.00668703144905
ko05144	Malaria	1/1166	45/7206	0.00687968612589
ko00071	Fatty acid degradation	1/1166	45/7206	0.00687968612589
ko05016	Huntington's disease	21/1166	215/7206	0.00824911815444
ko00480	Glutathione metabolism	2/1166	55/7206	0.00869639845457
ko04630	Jak-STAT signaling pathway	11/1166	132/7206	0.0117766278876
ko05166	HTLV-I infection	32/1166	292/7206	0.0118162696264
ko04510	Focal adhesion	25/1166	240/7206	0.0123508639928
ko04146	Peroxisome	6/1166	89/7206	0.0129950544898
ko04371	Apelin signaling pathway	41/1166	177/7206	0.0130945679459
ko00330	Arginine and proline metabolism	3/1166	61/7206	0.0133547296841
ko03320	PPAR signaling pathway	4/1166	69/7206	0.0135768635543
ko04622	RIG-I-like receptor signaling pathway	3/1166	62/7206	0.013767796253
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1166	40/7206	0.0154738604527
ko04658	Th1 and Th2 cell differentiation	7/1166	96/7206	0.0167181582127
ko04912	GnRH signaling pathway	30/1166	122/7206	0.0176117544691
ko04657	IL-17 signaling pathway	6/1166	87/7206	0.0179297103725
ko05133	Pertussis	6/1166	87/7206	0.0179297103725
ko04964	Proximal tubule bicarbonate reclamation	10/1166	29/7206	0.0183394080128
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1166	182/7206	0.0186555636813
ko00562	Inositol phosphate metabolism	23/1166	89/7206	0.0193686629194
ko05145	Toxoplasmosis	11/1166	126/7206	0.0199840378678
ko00982	Drug metabolism - cytochrome P450	1/1166	37/7206	0.0226905864639
ko04210	Apoptosis	18/1166	180/7206	0.023553813335
ko00630	Glyoxylate and dicarboxylate metabolism	1/1166	38/7206	0.0237811036
ko05131	Shigellosis	6/1166	82/7206	0.0237853068096
ko03018	RNA degradation	6/1166	84/7206	0.0241068348819
ko00310	Lysine degradation	5/1166	73/7206	0.0252301074282
ko04115	p53 signaling pathway	5/1166	74/7206	0.0253072838994
ko04640	Hematopoietic cell lineage	4/1166	64/7206	0.0262706709364
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1166	135/7206	0.0339092527923
ko04214	Apoptosis - fly	5/1166	72/7206	0.0348786871493
ko05202	Transcriptional misregulation in cancer	20/1166	188/7206	0.0350435653217
ko04330	Notch signaling pathway	4/1166	62/7206	0.0364495640384
ko05215	Prostate cancer	10/1166	111/7206	0.0374143690479
ko04015	Rap1 signaling pathway	58/1166	278/7206	0.0374182987593
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1166	100/7206	0.0395502427538
ko00512	Mucin type O-glycan biosynthesis	9/1166	29/7206	0.040517642866
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1166	92/7206	0.0466091267925
ko05034	Alcoholism	50/1166	238/7206	0.0483619505178
ko05206	MicroRNAs in cancer	19/1166	177/7206	0.0490915157029
ko04217	Necroptosis	19/1166	178/7206	0.0494280457726