ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1166	423/7206	9.48785769534e-49
ko04724	Glutamatergic synapse	87/1166	152/7206	1.80864939643e-31
ko05033	Nicotine addiction	48/1166	56/7206	1.77722716936e-30
ko05032	Morphine addiction	68/1166	110/7206	1.37488563849e-27
ko04727	GABAergic synapse	65/1166	110/7206	7.99109256319e-25
ko04721	Synaptic vesicle cycle	52/1166	80/7206	7.81309039736e-23
ko04713	Circadian entrainment	71/1166	136/7206	1.29968907262e-22
ko04725	Cholinergic synapse	76/1166	160/7206	7.14642247247e-21
ko04728	Dopaminergic synapse	83/1166	185/7206	1.08654054205e-20
ko04024	cAMP signaling pathway	105/1166	279/7206	9.76550105939e-19
ko04723	Retrograde endocannabinoid signaling	77/1166	175/7206	1.18932075475e-18
ko04742	Taste transduction	38/1166	61/7206	4.28205012377e-16
ko04911	Insulin secretion	54/1166	117/7206	1.68655505369e-14
ko04020	Calcium signaling pathway	91/1166	265/7206	1.84298988827e-13
ko04744	Phototransduction	25/1166	36/7206	1.31217497182e-12
ko04726	Serotonergic synapse	56/1166	137/7206	2.88393967163e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1166	205/7206	6.24002347844e-12
ko04921	Oxytocin signaling pathway	73/1166	209/7206	2.14627600724e-11
ko04360	Axon guidance	77/1166	233/7206	9.69978567657e-11
ko03040	Spliceosome	1/1166	145/7206	3.16178661404e-10
ko05031	Amphetamine addiction	39/1166	91/7206	1.18249530659e-09
ko05030	Cocaine addiction	33/1166	73/7206	4.38847642988e-09
ko04720	Long-term potentiation	39/1166	99/7206	2.09183672128e-08
ko05203	Viral carcinogenesis	15/1166	277/7206	4.13226303158e-08
ko05168	Herpes simplex infection	6/1166	182/7206	5.68208619828e-08
ko03013	RNA transport	5/1166	166/7206	8.73607950207e-08
ko04970	Salivary secretion	37/1166	95/7206	1.14833206574e-07
ko04971	Gastric acid secretion	36/1166	98/7206	5.9360388307e-07
ko04060	Cytokine-cytokine receptor interaction	9/1166	191/7206	1.20465310665e-06
ko05164	Influenza A	7/1166	167/7206	1.91450332868e-06
ko05322	Systemic lupus erythematosus	6/1166	151/7206	3.35167245551e-06
ko04925	Aldosterone synthesis and secretion	36/1166	105/7206	5.53217303948e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1166	74/7206	7.21222087853e-06
ko04740	Olfactory transduction	29/1166	80/7206	1.0235990959e-05
ko04010	MAPK signaling pathway	82/1166	321/7206	1.20029207909e-05
ko04022	cGMP-PKG signaling pathway	60/1166	216/7206	1.25668029389e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1166	79/7206	2.04947349201e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1166	79/7206	3.53530283016e-05
ko04141	Protein processing in endoplasmic reticulum	11/1166	184/7206	4.01179197463e-05
ko04966	Collecting duct acid secretion	13/1166	26/7206	6.37899807899e-05
ko04972	Pancreatic secretion	35/1166	111/7206	6.83546678343e-05
ko04070	Phosphatidylinositol signaling system	35/1166	112/7206	7.38219601657e-05
ko04514	Cell adhesion molecules (CAMs)	39/1166	130/7206	9.08391865997e-05
ko04120	Ubiquitin mediated proteolysis	7/1166	138/7206	9.42605175156e-05
ko05205	Proteoglycans in cancer	22/1166	271/7206	9.98888020785e-05
ko05414	Dilated cardiomyopathy	34/1166	112/7206	0.000144112477294
ko04924	Renin secretion	28/1166	86/7206	0.000161143316375
ko05169	Epstein-Barr virus infection	15/1166	206/7206	0.000165800700185
ko04540	Gap junction	37/1166	128/7206	0.000238437112097
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1166	59/7206	0.000243676515269
ko04621	NOD-like receptor signaling pathway	10/1166	157/7206	0.00027084691212
ko00240	Pyrimidine metabolism	5/1166	110/7206	0.000336670798517
ko04260	Cardiac muscle contraction	30/1166	98/7206	0.000430853010302
ko04915	Estrogen signaling pathway	37/1166	131/7206	0.000437742782449
ko04730	Long-term depression	25/1166	78/7206	0.000497738663252
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1166	14/7206	0.000550703664449
ko04014	Ras signaling pathway	67/1166	279/7206	0.00062658834254
ko04976	Bile secretion	25/1166	80/7206	0.000662641456166
ko05110	Vibrio cholerae infection	21/1166	63/7206	0.000784489449378
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1166	182/7206	0.00100794425448
ko04146	Peroxisome	4/1166	89/7206	0.00121045729927
ko00480	Glutathione metabolism	1/1166	55/7206	0.00133730743218
ko04072	Phospholipase D signaling pathway	49/1166	197/7206	0.00156834047868
ko04640	Hematopoietic cell lineage	2/1166	64/7206	0.00181629823646
ko04064	NF-kappa B signaling pathway	5/1166	96/7206	0.00185527713196
ko00590	Arachidonic acid metabolism	1/1166	52/7206	0.00198324550685
ko05140	Leishmaniasis	3/1166	75/7206	0.00227490210298
ko03018	RNA degradation	4/1166	84/7206	0.00247569330286
ko05162	Measles	8/1166	120/7206	0.00253159031646
ko04923	Regulation of lipolysis in adipocytes	23/1166	77/7206	0.00261591337911
ko00330	Arginine and proline metabolism	2/1166	61/7206	0.00266726409696
ko04964	Proximal tubule bicarbonate reclamation	11/1166	29/7206	0.00389748804903
ko03420	Nucleotide excision repair	1/1166	46/7206	0.00445501073442
ko05161	Hepatitis B	15/1166	173/7206	0.00468563755209
ko00260	Glycine, serine and threonine metabolism	1/1166	48/7206	0.00470215703039
ko04612	Antigen processing and presentation	4/1166	77/7206	0.00488804194615
ko04658	Th1 and Th2 cell differentiation	6/1166	96/7206	0.00499899379012
ko04745	Phototransduction - fly	13/1166	38/7206	0.00618359161409
ko03022	Basal transcription factors	1/1166	44/7206	0.00668703144905
ko05144	Malaria	1/1166	45/7206	0.00687968612589
ko00071	Fatty acid degradation	1/1166	45/7206	0.00687968612589
ko04110	Cell cycle	12/1166	145/7206	0.00831052989932
ko00280	Valine, leucine and isoleucine degradation	2/1166	54/7206	0.00841594046125
ko04750	Inflammatory mediator regulation of TRP channels	31/1166	122/7206	0.00866516661534
ko04371	Apelin signaling pathway	42/1166	177/7206	0.00935493874955
ko04391	Hippo signaling pathway - fly	24/1166	90/7206	0.00937861620737
ko04214	Apoptosis - fly	4/1166	72/7206	0.00967649957636
ko05131	Shigellosis	5/1166	82/7206	0.00971236468601
ko05145	Toxoplasmosis	10/1166	126/7206	0.00984939821823
ko04630	Jak-STAT signaling pathway	11/1166	132/7206	0.0117766278876
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1166	100/7206	0.0129061210586
ko03320	PPAR signaling pathway	4/1166	69/7206	0.0135768635543
ko04622	RIG-I-like receptor signaling pathway	3/1166	62/7206	0.013767796253
ko01200	Carbon metabolism	11/1166	128/7206	0.0153521012089
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1166	40/7206	0.0154738604527
ko04015	Rap1 signaling pathway	60/1166	278/7206	0.0157888020647
ko05219	Bladder cancer	2/1166	48/7206	0.0176709296429
ko04657	IL-17 signaling pathway	6/1166	87/7206	0.0179297103725
ko00380	Tryptophan metabolism	2/1166	50/7206	0.0185088220035
ko00982	Drug metabolism - cytochrome P450	1/1166	37/7206	0.0226905864639
ko04140	Autophagy - animal	16/1166	164/7206	0.0237604504766
ko04137	Mitophagy - animal	6/1166	82/7206	0.0237853068096
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1166	15/7206	0.0237966919119
ko04115	p53 signaling pathway	5/1166	74/7206	0.0253072838994
ko00620	Pyruvate metabolism	2/1166	46/7206	0.0256567305921
ko04918	Thyroid hormone synthesis	22/1166	86/7206	0.0257558652736
ko05321	Inflammatory bowel disease (IBD)	3/1166	56/7206	0.0269619044657
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1166	26/7206	0.0270104758413
ko04620	Toll-like receptor signaling pathway	8/1166	100/7206	0.0274595851699
ko05133	Pertussis	7/1166	87/7206	0.0393176102079
ko04210	Apoptosis	19/1166	180/7206	0.0398368403213
ko00562	Inositol phosphate metabolism	22/1166	89/7206	0.040901678497
ko05034	Alcoholism	50/1166	238/7206	0.0483619505178
ko04916	Melanogenesis	32/1166	142/7206	0.0493485133761
ko04136	Autophagy - other	1/1166	31/7206	0.0494005440338
ko04217	Necroptosis	19/1166	178/7206	0.0494280457726
ko04962	Vasopressin-regulated water reabsorption	15/1166	58/7206	0.0496464582083