ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 28/332 191/7206 3.95902457143e-08 ko04380 Osteoclast differentiation 22/332 134/7206 1.5821709998e-07 ko04650 Natural killer cell mediated cytotoxicity 18/332 97/7206 3.33205503875e-07 ko05162 Measles 20/332 120/7206 4.57309693097e-07 ko05164 Influenza A 24/332 167/7206 5.58716482073e-07 ko04621 NOD-like receptor signaling pathway 22/332 157/7206 2.58298152443e-06 ko05340 Primary immunodeficiency 9/332 30/7206 5.08644155872e-06 ko04217 Necroptosis 23/332 178/7206 6.23054806404e-06 ko05152 Tuberculosis 23/332 187/7206 1.42644645927e-05 ko05140 Leishmaniasis 13/332 75/7206 3.1652339288e-05 ko05321 Inflammatory bowel disease (IBD) 11/332 56/7206 3.88126389846e-05 ko04630 Jak-STAT signaling pathway 17/332 132/7206 0.000107157518673 ko05145 Toxoplasmosis 16/332 126/7206 0.000201342427925 ko00120 Primary bile acid biosynthesis 6/332 20/7206 0.00020452478985 ko04610 Complement and coagulation cascades 12/332 79/7206 0.000236600314424 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/332 191/7206 0.000282579003813 ko05161 Hepatitis B 19/332 173/7206 0.000359124513476 ko05168 Herpes simplex infection 19/332 182/7206 0.000846436117406 ko05150 Staphylococcus aureus infection 7/332 36/7206 0.00108609891581 ko04658 Th1 and Th2 cell differentiation 12/332 96/7206 0.00142998305759 ko04660 T cell receptor signaling pathway 14/332 124/7206 0.00161494222586 ko04145 Phagosome 17/332 162/7206 0.00165587043213 ko04620 Toll-like receptor signaling pathway 12/332 100/7206 0.00203940933781 ko04662 B cell receptor signaling pathway 11/332 88/7206 0.0022358323354 ko04390 Hippo signaling pathway 1/332 188/7206 0.00230087132026 ko04612 Antigen processing and presentation 10/332 77/7206 0.00263636762448 ko04664 Fc epsilon RI signaling pathway 10/332 77/7206 0.00263636762448 ko00051 Fructose and mannose metabolism 7/332 42/7206 0.00276926110862 ko04668 TNF signaling pathway 13/332 120/7206 0.0033843320921 ko04611 Platelet activation 16/332 163/7206 0.00375023821352 ko04064 NF-kappa B signaling pathway 11/332 96/7206 0.00444258213568 ko04670 Leukocyte transendothelial migration 15/332 151/7206 0.00469700484068 ko05133 Pertussis 10/332 87/7206 0.00640970003929 ko00590 Arachidonic acid metabolism 7/332 52/7206 0.00927273270979 ko04659 Th17 cell differentiation 11/332 106/7206 0.00932003703746 ko00592 alpha-Linolenic acid metabolism 4/332 19/7206 0.00989657174314 ko04623 Cytosolic DNA-sensing pathway 6/332 41/7206 0.0105043419053 ko05230 Central carbon metabolism in cancer 9/332 81/7206 0.0117625268036 ko04137 Mitophagy - animal 9/332 82/7206 0.0126952907358 ko04710 Circadian rhythm 6/332 43/7206 0.0131903235282 ko04666 Fc gamma R-mediated phagocytosis 12/332 122/7206 0.0132388560893 ko05132 Salmonella infection 10/332 98/7206 0.0143966122053 ko03040 Spliceosome 1/332 145/7206 0.0149132983254 ko05418 Fluid shear stress and atherosclerosis 15/332 173/7206 0.0158944779957 ko05160 Hepatitis C 14/332 153/7206 0.0165124759876 ko04310 Wnt signaling pathway 2/332 181/7206 0.0178603838842 ko05330 Allograft rejection 4/332 24/7206 0.0226501539069 ko01524 Platinum drug resistance 8/332 76/7206 0.023020266286 ko04723 Retrograde endocannabinoid signaling 2/332 175/7206 0.0257988041102 ko04672 Intestinal immune network for IgA production 5/332 37/7206 0.0261399023139 ko00982 Drug metabolism - cytochrome P450 5/332 37/7206 0.0261399023139 ko05034 Alcoholism 4/332 238/7206 0.0261723309477 ko04210 Apoptosis 15/332 180/7206 0.0277905621067 ko04142 Lysosome 13/332 151/7206 0.0279925305653 ko04066 HIF-1 signaling pathway 11/332 123/7206 0.0288372920237 ko03010 Ribosome 1/332 129/7206 0.0313141328517 ko04070 Phosphatidylinositol signaling system 10/332 112/7206 0.0380630511312 ko05310 Asthma 3/332 17/7206 0.0407775885035 ko04080 Neuroactive ligand-receptor interaction 11/332 423/7206 0.041577322123 ko05320 Autoimmune thyroid disease 4/332 29/7206 0.0423342912959 ko05332 Graft-versus-host disease 3/332 18/7206 0.0473127338984 ko05012 Parkinson's disease 2/332 155/7206 0.0494551960526