ko pathway ratio_in_study ratio_in_pop p_value ko00380 Tryptophan metabolism 14/331 50/7206 2.9547130846e-08 ko00120 Primary bile acid biosynthesis 9/331 20/7206 8.76797522089e-08 ko00592 alpha-Linolenic acid metabolism 8/331 19/7206 8.83290880585e-07 ko04146 Peroxisome 16/331 89/7206 2.26477082627e-06 ko00071 Fatty acid degradation 10/331 45/7206 2.76528177921e-05 ko00362 Benzoate degradation 4/331 6/7206 6.09500648698e-05 ko01200 Carbon metabolism 17/331 128/7206 6.98672585101e-05 ko03320 PPAR signaling pathway 11/331 69/7206 0.00027082519034 ko04972 Pancreatic secretion 14/331 111/7206 0.000519906635919 ko00051 Fructose and mannose metabolism 8/331 42/7206 0.000545894479499 ko04710 Circadian rhythm 8/331 43/7206 0.00064433919592 ko00950 Isoquinoline alkaloid biosynthesis 4/331 10/7206 0.000736488161639 ko00680 Methane metabolism 7/331 34/7206 0.00074417456641 ko00360 Phenylalanine metabolism 5/331 17/7206 0.000776938216126 ko00500 Starch and sucrose metabolism 7/331 35/7206 0.0008941759331 ko01212 Fatty acid metabolism 9/331 60/7206 0.00151810289715 ko01230 Biosynthesis of amino acids 11/331 85/7206 0.00164510511676 ko00330 Arginine and proline metabolism 9/331 61/7206 0.00171053272504 ko00564 Glycerophospholipid metabolism 12/331 99/7206 0.00182310107142 ko00561 Glycerolipid metabolism 9/331 63/7206 0.00215390977865 ko00590 Arachidonic acid metabolism 8/331 52/7206 0.00233424801325 ko00983 Drug metabolism - other enzymes 7/331 42/7206 0.00272261654251 ko00591 Linoleic acid metabolism 5/331 22/7206 0.00273599702372 ko04976 Bile secretion 10/331 80/7206 0.00342813094258 ko05166 HTLV-I infection 4/331 292/7206 0.00390260151214 ko04151 PI3K-Akt signaling pathway 7/331 390/7206 0.0039560188607 ko00640 Propanoate metabolism 6/331 34/7206 0.00405435857216 ko00220 Arginine biosynthesis 5/331 24/7206 0.00409515687476 ko04974 Protein digestion and absorption 11/331 96/7206 0.00434276710595 ko00340 Histidine metabolism 5/331 25/7206 0.00492982575788 ko00260 Glycine, serine and threonine metabolism 7/331 48/7206 0.00587274343322 ko00310 Lysine degradation 9/331 73/7206 0.00591454145607 ko05169 Epstein-Barr virus infection 2/331 206/7206 0.00622674878993 ko00710 Carbon fixation in photosynthetic organisms 5/331 27/7206 0.00694847817954 ko05200 Pathways in cancer 11/331 492/7206 0.00711647342355 ko00250 Alanine, aspartate and glutamate metabolism 6/331 38/7206 0.00713496037366 ko00630 Glyoxylate and dicarboxylate metabolism 6/331 38/7206 0.00713496037366 ko05203 Viral carcinogenesis 4/331 277/7206 0.00759281012001 ko02010 ABC transporters 6/331 39/7206 0.00811464403999 ko00290 Valine, leucine and isoleucine biosynthesis 2/331 4/7206 0.0118675489991 ko04136 Autophagy - other 5/331 31/7206 0.0125907360645 ko04010 MAPK signaling pathway 6/331 321/7206 0.0133889824589 ko04110 Cell cycle 1/331 145/7206 0.0148923515747 ko00350 Tyrosine metabolism 5/331 33/7206 0.0163233029356 ko04977 Vitamin digestion and absorption 4/331 22/7206 0.016588352309 ko04144 Endocytosis 7/331 342/7206 0.0167778613719 ko04070 Phosphatidylinositol signaling system 11/331 112/7206 0.0184578096561 ko04975 Fat digestion and absorption 5/331 35/7206 0.0207270462882 ko04380 Osteoclast differentiation 1/331 134/7206 0.0214698307259 ko01040 Biosynthesis of unsaturated fatty acids 4/331 25/7206 0.0257600834892 ko00982 Drug metabolism - cytochrome P450 5/331 37/7206 0.025841635636 ko00650 Butanoate metabolism 4/331 26/7206 0.0293749405364 ko04270 Vascular smooth muscle contraction 13/331 154/7206 0.0301706484826 ko03010 Ribosome 1/331 129/7206 0.0312398197581 ko04138 Autophagy - yeast 8/331 81/7206 0.0317804274589 ko04978 Mineral absorption 5/331 40/7206 0.0349157443144 ko03013 RNA transport 2/331 166/7206 0.0359163495415 ko00280 Valine, leucine and isoleucine degradation 6/331 54/7206 0.0362893799817 ko04960 Aldosterone-regulated sodium reabsorption 5/331 41/7206 0.0383265577223 ko00565 Ether lipid metabolism 5/331 42/7206 0.0419341421458 ko00901 Indole alkaloid biosynthesis 1/331 1/7206 0.0459339439355 ko04660 T cell receptor signaling pathway 1/331 124/7206 0.0465807733171 ko05322 Systemic lupus erythematosus 2/331 151/7206 0.0485331977471 ko04390 Hippo signaling pathway 3/331 188/7206 0.0495392721193 ko05202 Transcriptional misregulation in cancer 3/331 188/7206 0.0495392721193