ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 17/198 80/7206 3.24077326747e-11 ko04724 Glutamatergic synapse 21/198 152/7206 7.48684425332e-10 ko05033 Nicotine addiction 13/198 56/7206 2.2991877976e-09 ko04728 Dopaminergic synapse 22/198 185/7206 5.21976954453e-09 ko04080 Neuroactive ligand-receptor interaction 34/198 423/7206 1.01101018359e-08 ko04713 Circadian entrainment 18/198 136/7206 2.60934401685e-08 ko04727 GABAergic synapse 16/198 110/7206 4.15142047945e-08 ko05032 Morphine addiction 15/198 110/7206 2.67677401145e-07 ko04911 Insulin secretion 15/198 117/7206 6.06880784017e-07 ko04723 Retrograde endocannabinoid signaling 18/198 175/7206 1.24725941819e-06 ko05030 Cocaine addiction 10/198 73/7206 2.68948566302e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 10/198 74/7206 3.03633840961e-05 ko05031 Amphetamine addiction 11/198 91/7206 3.5361197982e-05 ko04972 Pancreatic secretion 12/198 111/7206 4.82077477008e-05 ko05110 Vibrio cholerae infection 9/198 63/7206 4.87612007341e-05 ko04966 Collecting duct acid secretion 6/198 26/7206 5.80200573494e-05 ko04024 cAMP signaling pathway 20/198 279/7206 7.49573236747e-05 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/198 92/7206 0.000198396047792 ko04970 Salivary secretion 10/198 95/7206 0.000258863012262 ko04726 Serotonergic synapse 12/198 137/7206 0.000363899039778 ko04725 Cholinergic synapse 13/198 160/7206 0.000433895505401 ko04145 Phagosome 13/198 162/7206 0.000489089492587 ko04514 Cell adhesion molecules (CAMs) 11/198 130/7206 0.000854265035127 ko04730 Long-term depression 8/198 78/7206 0.00127285668162 ko04742 Taste transduction 7/198 61/7206 0.00132014301257 ko04261 Adrenergic signaling in cardiomyocytes 14/198 205/7206 0.00147941365309 ko05323 Rheumatoid arthritis 8/198 89/7206 0.00296630303225 ko05034 Alcoholism 15/198 238/7206 0.00341908732983 ko05166 HTLV-I infection 1/198 292/7206 0.00506903078714 ko04720 Long-term potentiation 8/198 99/7206 0.00569882465238 ko04964 Proximal tubule bicarbonate reclamation 4/198 29/7206 0.00766602029352 ko04020 Calcium signaling pathway 14/198 265/7206 0.0189029991383 ko00190 Oxidative phosphorylation 8/198 127/7206 0.0233681634718 ko04015 Rap1 signaling pathway 14/198 278/7206 0.024036801327 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/198 1/7206 0.0274771024147