ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 36/502 191/7206 2.63369388784e-08 ko00120 Primary bile acid biosynthesis 9/502 20/7206 3.02014041895e-06 ko04672 Intestinal immune network for IgA production 12/502 37/7206 4.24511221284e-06 ko04380 Osteoclast differentiation 24/502 134/7206 1.43980415428e-05 ko05321 Inflammatory bowel disease (IBD) 14/502 56/7206 2.01305630213e-05 ko04658 Th1 and Th2 cell differentiation 19/502 96/7206 2.67334656461e-05 ko05140 Leishmaniasis 16/502 75/7206 4.41972806966e-05 ko04610 Complement and coagulation cascades 16/502 79/7206 8.59440283176e-05 ko04650 Natural killer cell mediated cytotoxicity 18/502 97/7206 0.00010517334139 ko04621 NOD-like receptor signaling pathway 24/502 157/7206 0.00020961623404 ko05164 Influenza A 25/502 167/7206 0.000275651540344 ko00350 Tyrosine metabolism 9/502 33/7206 0.000305884740295 ko04659 Th17 cell differentiation 18/502 106/7206 0.000336132516942 ko04710 Circadian rhythm 10/502 43/7206 0.000580809305791 ko05150 Staphylococcus aureus infection 9/502 36/7206 0.000618824762401 ko03040 Spliceosome 1/502 145/7206 0.000712602440053 ko00590 Arachidonic acid metabolism 11/502 52/7206 0.000739416284299 ko05340 Primary immunodeficiency 8/502 30/7206 0.000780328811375 ko03013 RNA transport 2/502 166/7206 0.000974874683027 ko05145 Toxoplasmosis 19/502 126/7206 0.00116981180254 ko04640 Hematopoietic cell lineage 12/502 64/7206 0.00133527218379 ko00592 alpha-Linolenic acid metabolism 6/502 19/7206 0.00137545725243 ko04137 Mitophagy - animal 14/502 82/7206 0.00142550156107 ko03010 Ribosome 1/502 129/7206 0.00144882353435 ko05320 Autoimmune thyroid disease 7/502 29/7206 0.00309623015491 ko04064 NF-kappa B signaling pathway 15/502 96/7206 0.00337408709766 ko04660 T cell receptor signaling pathway 18/502 124/7206 0.00346562838924 ko00950 Isoquinoline alkaloid biosynthesis 4/502 10/7206 0.00348363714933 ko05034 Alcoholism 6/502 238/7206 0.00397078783845 ko04146 Peroxisome 14/502 89/7206 0.00471271531394 ko05310 Asthma 5/502 17/7206 0.0049293518023 ko00360 Phenylalanine metabolism 5/502 17/7206 0.0049293518023 ko05330 Allograft rejection 6/502 24/7206 0.00506408061733 ko05162 Measles 17/502 120/7206 0.00539210712042 ko04217 Necroptosis 22/502 178/7206 0.00707340359939 ko00565 Ether lipid metabolism 8/502 42/7206 0.00752474843612 ko05152 Tuberculosis 23/502 187/7206 0.00788437454513 ko04068 FoxO signaling pathway 21/502 167/7206 0.00799523613327 ko00330 Arginine and proline metabolism 10/502 61/7206 0.00884564354185 ko05323 Rheumatoid arthritis 13/502 89/7206 0.00981005657484 ko04611 Platelet activation 20/502 163/7206 0.011894432847 ko00982 Drug metabolism - cytochrome P450 7/502 37/7206 0.0126041889885 ko04110 Cell cycle 3/502 145/7206 0.012936041416 ko04390 Hippo signaling pathway 5/502 188/7206 0.0132970120058 ko04670 Leukocyte transendothelial migration 19/502 151/7206 0.0137895661558 ko04630 Jak-STAT signaling pathway 17/502 132/7206 0.0139106521635 ko04933 AGE-RAGE signaling pathway in diabetic complications 17/502 135/7206 0.0155966111743 ko04662 B cell receptor signaling pathway 12/502 88/7206 0.0199991295477 ko04111 Cell cycle - yeast 1/502 90/7206 0.0203593942559 ko04664 Fc epsilon RI signaling pathway 11/502 77/7206 0.0207050477676 ko03015 mRNA surveillance pathway 1/502 93/7206 0.0211742249107 ko00140 Steroid hormone biosynthesis 7/502 41/7206 0.0216639334095 ko05203 Viral carcinogenesis 10/502 277/7206 0.0218359556787 ko04514 Cell adhesion molecules (CAMs) 16/502 130/7206 0.0226526379416 ko04310 Wnt signaling pathway 5/502 181/7206 0.024904702873 ko05168 Herpes simplex infection 21/502 182/7206 0.0252372687724 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/502 4/7206 0.0264448080407 ko00643 Styrene degradation 2/502 4/7206 0.0264448080407 ko04620 Toll-like receptor signaling pathway 13/502 100/7206 0.0268111935761 ko03320 PPAR signaling pathway 10/502 69/7206 0.0270034370868 ko05332 Graft-versus-host disease 4/502 18/7206 0.0325530816307 ko05224 Breast cancer 5/502 174/7206 0.0330257253837 ko04540 Gap junction 3/502 128/7206 0.0343336413682 ko05144 Malaria 7/502 45/7206 0.0344668091896 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/502 5/7206 0.0420597582578 ko00281 Geraniol degradation 2/502 5/7206 0.0420597582578 ko04721 Synaptic vesicle cycle 1/502 80/7206 0.0432511553066 ko04668 TNF signaling pathway 14/502 120/7206 0.0470005439481