ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 111/710 423/7206 9.80074621306e-24 ko05033 Nicotine addiction 27/710 56/7206 1.93412816276e-13 ko04724 Glutamatergic synapse 46/710 152/7206 1.08840311936e-12 ko04713 Circadian entrainment 43/710 136/7206 1.16214051512e-12 ko05032 Morphine addiction 37/710 110/7206 5.67518049942e-12 ko04727 GABAergic synapse 36/710 110/7206 2.73279159113e-11 ko04911 Insulin secretion 35/710 117/7206 8.39258784424e-10 ko04020 Calcium signaling pathway 59/710 265/7206 1.21967510582e-09 ko04728 Dopaminergic synapse 44/710 185/7206 2.04003265876e-08 ko04725 Cholinergic synapse 39/710 160/7206 5.48941588685e-08 ko04726 Serotonergic synapse 35/710 137/7206 7.64038517064e-08 ko04723 Retrograde endocannabinoid signaling 41/710 175/7206 9.24963427322e-08 ko04024 cAMP signaling pathway 55/710 279/7206 3.31825506942e-07 ko05031 Amphetamine addiction 25/710 91/7206 1.32628922263e-06 ko04921 Oxytocin signaling pathway 43/710 209/7206 2.50340793864e-06 ko04742 Taste transduction 19/710 61/7206 3.26568377829e-06 ko04721 Synaptic vesicle cycle 22/710 80/7206 5.61136734128e-06 ko04971 Gastric acid secretion 25/710 98/7206 5.76095233985e-06 ko04710 Circadian rhythm 15/710 43/7206 7.50911449604e-06 ko03010 Ribosome 1/710 129/7206 3.64203325834e-05 ko05322 Systemic lupus erythematosus 2/710 151/7206 4.17169856535e-05 ko03013 RNA transport 3/710 166/7206 5.78735665664e-05 ko04925 Aldosterone synthesis and secretion 24/710 105/7206 7.96667315833e-05 ko04970 Salivary secretion 22/710 95/7206 0.000151087235844 ko04261 Adrenergic signaling in cardiomyocytes 37/710 205/7206 0.000292862861582 ko04070 Phosphatidylinositol signaling system 24/710 112/7206 0.000293300243288 ko05164 Influenza A 4/710 167/7206 0.000309520990568 ko04972 Pancreatic secretion 23/710 111/7206 0.000536409702886 ko04720 Long-term potentiation 21/710 99/7206 0.000558267632858 ko04022 cGMP-PKG signaling pathway 37/710 216/7206 0.000696125100313 ko04730 Long-term depression 18/710 78/7206 0.000740021936248 ko04120 Ubiquitin mediated proteolysis 3/710 138/7206 0.000743994313515 ko04711 Circadian rhythm - fly 6/710 13/7206 0.000837613064546 ko04976 Bile secretion 18/710 80/7206 0.000856597975939 ko04514 Cell adhesion molecules (CAMs) 25/710 130/7206 0.000916951404409 ko04964 Proximal tubule bicarbonate reclamation 9/710 29/7206 0.00135937758272 ko05168 Herpes simplex infection 6/710 182/7206 0.00141753727872 ko04960 Aldosterone-regulated sodium reabsorption 11/710 41/7206 0.00156713007232 ko04750 Inflammatory mediator regulation of TRP channels 23/710 122/7206 0.00192965923802 ko05030 Cocaine addiction 16/710 73/7206 0.00213576389488 ko04919 Thyroid hormone signaling pathway 26/710 143/7206 0.00249489935848 ko04621 NOD-like receptor signaling pathway 5/710 157/7206 0.00256000264046 ko04745 Phototransduction - fly 10/710 38/7206 0.00296475609273 ko00643 Styrene degradation 3/710 4/7206 0.00353091550515 ko04922 Glucagon signaling pathway 23/710 128/7206 0.00399654741532 ko05203 Viral carcinogenesis 14/710 277/7206 0.00519422635309 ko05140 Leishmaniasis 1/710 75/7206 0.00593379432381 ko05130 Pathogenic Escherichia coli infection 1/710 77/7206 0.00602463174177 ko04612 Antigen processing and presentation 1/710 77/7206 0.00602463174177 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/710 59/7206 0.00629234073929 ko04110 Cell cycle 5/710 145/7206 0.0067662734862 ko04360 Axon guidance 36/710 233/7206 0.00686198796381 ko05016 Huntington's disease 10/710 215/7206 0.00715566038825 ko04141 Protein processing in endoplasmic reticulum 8/710 184/7206 0.00812303995443 ko04371 Apelin signaling pathway 28/710 177/7206 0.0103124290249 ko04924 Renin secretion 16/710 86/7206 0.0103231810655 ko00120 Primary bile acid biosynthesis 6/710 20/7206 0.0103805943902 ko05133 Pertussis 2/710 87/7206 0.0107433183973 ko05162 Measles 4/710 120/7206 0.0124357887538 ko00350 Tyrosine metabolism 8/710 33/7206 0.012765273456 ko04217 Necroptosis 8/710 178/7206 0.0146361556166 ko00362 Benzoate degradation 3/710 6/7206 0.0151698221361 ko05014 Amyotrophic lateral sclerosis (ALS) 14/710 74/7206 0.0162434190091 ko04540 Gap junction 21/710 128/7206 0.0164363624493 ko04620 Toll-like receptor signaling pathway 3/710 100/7206 0.0167139871543 ko04973 Carbohydrate digestion and absorption 9/710 42/7206 0.0190027935667 ko05161 Hepatitis B 8/710 173/7206 0.019102168718 ko04658 Th1 and Th2 cell differentiation 3/710 96/7206 0.0233512427626 ko04918 Thyroid hormone synthesis 15/710 86/7206 0.0267658984597 ko04072 Phospholipase D signaling pathway 29/710 197/7206 0.0280971354304 ko00562 Inositol phosphate metabolism 15/710 89/7206 0.0317568116056 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/710 79/7206 0.0334840580401 ko04260 Cardiac muscle contraction 16/710 98/7206 0.0391015175064 ko04014 Ras signaling pathway 38/710 279/7206 0.0396591941583 ko05416 Viral myocarditis 1/710 55/7206 0.0396813931348 ko04214 Apoptosis - fly 2/710 72/7206 0.0442149896233 ko04657 IL-17 signaling pathway 3/710 87/7206 0.0445394200156