ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1237	423/7206	1.03129348477e-50
ko04724	Glutamatergic synapse	92/1237	152/7206	8.00082231916e-34
ko05033	Nicotine addiction	49/1237	56/7206	9.48967947601e-31
ko04713	Circadian entrainment	79/1237	136/7206	1.90996475138e-27
ko05032	Morphine addiction	67/1237	110/7206	4.24923410635e-25
ko04727	GABAergic synapse	66/1237	110/7206	3.29282877184e-24
ko04721	Synaptic vesicle cycle	52/1237	80/7206	1.30726200839e-21
ko04725	Cholinergic synapse	78/1237	160/7206	1.23366148423e-20
ko04728	Dopaminergic synapse	85/1237	185/7206	2.91537665913e-20
ko04024	cAMP signaling pathway	107/1237	279/7206	9.10110545134e-18
ko04020	Calcium signaling pathway	102/1237	265/7206	3.17792477984e-17
ko04723	Retrograde endocannabinoid signaling	77/1237	175/7206	4.16886527552e-17
ko04742	Taste transduction	39/1237	61/7206	3.79720591032e-16
ko04744	Phototransduction	28/1237	36/7206	2.11106902375e-15
ko04911	Insulin secretion	57/1237	117/7206	2.2502432048e-15
ko04726	Serotonergic synapse	63/1237	137/7206	2.49979469341e-15
ko04740	Olfactory transduction	42/1237	80/7206	4.51978158593e-13
ko04921	Oxytocin signaling pathway	79/1237	209/7206	4.805512708e-13
ko04720	Long-term potentiation	47/1237	99/7206	2.2140643711e-12
ko03040	Spliceosome	1/1237	145/7206	7.46585997122e-11
ko05031	Amphetamine addiction	42/1237	91/7206	1.03735249884e-10
ko04970	Salivary secretion	42/1237	95/7206	5.53685896704e-10
ko04261	Adrenergic signaling in cardiomyocytes	70/1237	205/7206	2.43735734931e-09
ko04360	Axon guidance	74/1237	233/7206	2.73133063659e-08
ko05203	Viral carcinogenesis	17/1237	277/7206	5.40707583558e-08
ko04925	Aldosterone synthesis and secretion	40/1237	105/7206	2.71385526576e-07
ko05030	Cocaine addiction	31/1237	73/7206	3.09577875154e-07
ko03013	RNA transport	7/1237	166/7206	5.82482713512e-07
ko05168	Herpes simplex infection	9/1237	182/7206	7.45007194346e-07
ko04060	Cytokine-cytokine receptor interaction	10/1237	191/7206	8.23129997408e-07
ko04022	cGMP-PKG signaling pathway	66/1237	216/7206	8.57360177287e-07
ko05322	Systemic lupus erythematosus	6/1237	151/7206	9.74568937261e-07
ko04971	Gastric acid secretion	37/1237	98/7206	9.93017791329e-07
ko04621	NOD-like receptor signaling pathway	7/1237	157/7206	1.68575713427e-06
ko04120	Ubiquitin mediated proteolysis	5/1237	138/7206	1.72705808356e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1237	74/7206	2.39552774674e-06
ko04966	Collecting duct acid secretion	15/1237	26/7206	3.55945829933e-06
ko04540	Gap junction	43/1237	128/7206	4.79169819261e-06
ko05164	Influenza A	9/1237	167/7206	6.19715993464e-06
ko04141	Protein processing in endoplasmic reticulum	11/1237	184/7206	9.87713486277e-06
ko04110	Cell cycle	7/1237	145/7206	1.03800843795e-05
ko04514	Cell adhesion molecules (CAMs)	42/1237	130/7206	1.86334641557e-05
ko04730	Long-term depression	29/1237	78/7206	2.41867931325e-05
ko04972	Pancreatic secretion	37/1237	111/7206	3.32079951049e-05
ko04010	MAPK signaling pathway	84/1237	321/7206	3.82405585593e-05
ko04924	Renin secretion	30/1237	86/7206	6.70832984596e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1237	79/7206	7.16801000959e-05
ko04612	Antigen processing and presentation	2/1237	77/7206	0.000106608364541
ko05169	Epstein-Barr virus infection	16/1237	206/7206	0.000107929978261
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1237	79/7206	0.000114928269578
ko04014	Ras signaling pathway	73/1237	279/7206	0.000126797227551
ko04976	Bile secretion	28/1237	80/7206	0.000126835588797
ko05140	Leishmaniasis	2/1237	75/7206	0.00015949664894
ko04064	NF-kappa B signaling pathway	4/1237	96/7206	0.000180791508983
ko04070	Phosphatidylinositol signaling system	35/1237	112/7206	0.000209104501921
ko04072	Phospholipase D signaling pathway	54/1237	197/7206	0.000249266399217
ko04745	Phototransduction - fly	16/1237	38/7206	0.000259956170214
ko04750	Inflammatory mediator regulation of TRP channels	37/1237	122/7206	0.000364058907954
ko04260	Cardiac muscle contraction	31/1237	98/7206	0.000379990483657
ko04610	Complement and coagulation cascades	3/1237	79/7206	0.000459454191794
ko05414	Dilated cardiomyopathy	34/1237	112/7206	0.000542769452538
ko04146	Peroxisome	4/1237	89/7206	0.000551948062812
ko05110	Vibrio cholerae infection	22/1237	63/7206	0.000592396701658
ko04371	Apelin signaling pathway	48/1237	177/7206	0.000791291516407
ko05205	Proteoglycans in cancer	27/1237	271/7206	0.000962261683247
ko05162	Measles	8/1237	120/7206	0.00131465347431
ko04214	Apoptosis - fly	3/1237	72/7206	0.00142682408081
ko04915	Estrogen signaling pathway	37/1237	131/7206	0.00143843813986
ko04330	Notch signaling pathway	2/1237	62/7206	0.00182448748196
ko04964	Proximal tubule bicarbonate reclamation	12/1237	29/7206	0.00182735820687
ko05161	Hepatitis B	15/1237	173/7206	0.00203649672414
ko03420	Nucleotide excision repair	1/1237	46/7206	0.00280667267176
ko05166	HTLV-I infection	32/1237	292/7206	0.00328282440341
ko03022	Basal transcription factors	1/1237	44/7206	0.00424342117517
ko00562	Inositol phosphate metabolism	26/1237	89/7206	0.00431165760509
ko05144	Malaria	1/1237	45/7206	0.00439485567162
ko00071	Fatty acid degradation	1/1237	45/7206	0.00439485567162
ko00240	Pyrimidine metabolism	8/1237	110/7206	0.004607121648
ko00310	Lysine degradation	4/1237	73/7206	0.00464791336824
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1237	59/7206	0.00468750169758
ko05131	Shigellosis	5/1237	82/7206	0.00478212825579
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1237	14/7206	0.00483482050474
ko04923	Regulation of lipolysis in adipocytes	23/1237	77/7206	0.00560350102943
ko04622	RIG-I-like receptor signaling pathway	3/1237	62/7206	0.00621598404922
ko04626	Plant-pathogen interaction	8/1237	18/7206	0.00635973089056
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1237	182/7206	0.00696174084257
ko05418	Fluid shear stress and atherosclerosis	17/1237	173/7206	0.00777968521263
ko00590	Arachidonic acid metabolism	2/1237	52/7206	0.0083791306314
ko05145	Toxoplasmosis	11/1237	126/7206	0.00858693948302
ko04657	IL-17 signaling pathway	6/1237	87/7206	0.00923914928922
ko05133	Pertussis	6/1237	87/7206	0.00923914928922
ko03018	RNA degradation	6/1237	84/7206	0.0125201872647
ko04922	Glucagon signaling pathway	33/1237	128/7206	0.0126027796957
ko04115	p53 signaling pathway	5/1237	74/7206	0.0128763709592
ko04710	Circadian rhythm	14/1237	43/7206	0.0131049714164
ko00630	Glyoxylate and dicarboxylate metabolism	1/1237	38/7206	0.0151212835151
ko00600	Sphingolipid metabolism	4/1237	63/7206	0.0182517744401
ko00480	Glutathione metabolism	3/1237	55/7206	0.018279901621
ko04015	Rap1 signaling pathway	63/1237	278/7206	0.0183170708765
ko05321	Inflammatory bowel disease (IBD)	3/1237	56/7206	0.0188621504861
ko04668	TNF signaling pathway	11/1237	120/7206	0.0195714942146
ko04658	Th1 and Th2 cell differentiation	8/1237	96/7206	0.0197497417156
ko04217	Necroptosis	19/1237	178/7206	0.0201408669146
ko04912	GnRH signaling pathway	31/1237	122/7206	0.020675072048
ko00860	Porphyrin and chlorophyll metabolism	1/1237	34/7206	0.0215697725694
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1237	100/7206	0.022882500337
ko04973	Carbohydrate digestion and absorption	13/1237	42/7206	0.0236281414515
ko04350	TGF-beta signaling pathway	9/1237	103/7206	0.0241859897037
ko03320	PPAR signaling pathway	5/1237	69/7206	0.0244113193728
ko00330	Arginine and proline metabolism	4/1237	61/7206	0.0255241135623
ko04930	Type II diabetes mellitus	16/1237	54/7206	0.0273421867093
ko05016	Huntington's disease	25/1237	215/7206	0.0274392814159
ko05132	Salmonella infection	9/1237	98/7206	0.0311892764369
ko01524	Platinum drug resistance	6/1237	76/7206	0.031205535551
ko05217	Basal cell carcinoma	5/1237	68/7206	0.0339627702966
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1237	40/7206	0.0358486754861
ko04640	Hematopoietic cell lineage	5/1237	64/7206	0.0454290379081
ko04630	Jak-STAT signaling pathway	14/1237	132/7206	0.0469339799339
ko05340	Primary immunodeficiency	1/1237	30/7206	0.0488146411174