ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 27/129 423/7206 4.52502269021e-09 ko04024 cAMP signaling pathway 18/129 279/7206 2.01051263625e-06 ko04022 cGMP-PKG signaling pathway 15/129 216/7206 6.32471961431e-06 ko04724 Glutamatergic synapse 12/129 152/7206 1.57177837895e-05 ko04261 Adrenergic signaling in cardiomyocytes 14/129 205/7206 1.5912563243e-05 ko04727 GABAergic synapse 10/129 110/7206 2.4545928221e-05 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/129 59/7206 7.87577651106e-05 ko04514 Cell adhesion molecules (CAMs) 10/129 130/7206 0.000103058580275 ko04964 Proximal tubule bicarbonate reclamation 5/129 29/7206 0.000143071048601 ko04911 Insulin secretion 9/129 117/7206 0.000231047528378 ko04970 Salivary secretion 8/129 95/7206 0.000279664470993 ko04971 Gastric acid secretion 8/129 98/7206 0.000346206370994 ko04540 Gap junction 9/129 128/7206 0.000452044627292 ko04925 Aldosterone synthesis and secretion 8/129 105/7206 0.000552555513777 ko04972 Pancreatic secretion 8/129 111/7206 0.000800122130734 ko04918 Thyroid hormone synthesis 7/129 86/7206 0.000831816713219 ko04020 Calcium signaling pathway 13/129 265/7206 0.000871456933758 ko04015 Rap1 signaling pathway 13/129 278/7206 0.00135233153559 ko04728 Dopaminergic synapse 10/129 185/7206 0.00170496090048 ko04720 Long-term potentiation 7/129 99/7206 0.00190257211434 ko05014 Amyotrophic lateral sclerosis (ALS) 6/129 74/7206 0.00200581703898 ko04725 Cholinergic synapse 9/129 160/7206 0.00221015181417 ko04713 Circadian entrainment 8/129 136/7206 0.00293994302153 ko04976 Bile secretion 6/129 80/7206 0.00298233649466 ko04921 Oxytocin signaling pathway 10/129 209/7206 0.004142121289 ko04924 Renin secretion 6/129 86/7206 0.00427756712324 ko04978 Mineral absorption 4/129 40/7206 0.00544199016278 ko05031 Amphetamine addiction 6/129 91/7206 0.00564135703318 ko04960 Aldosterone-regulated sodium reabsorption 4/129 41/7206 0.00594811616464 ko04973 Carbohydrate digestion and absorption 4/129 42/7206 0.00648467255768 ko04260 Cardiac muscle contraction 6/129 98/7206 0.00805213644741 ko04360 Axon guidance 10/129 233/7206 0.00876614505454 ko05030 Cocaine addiction 5/129 73/7206 0.00967396617183 ko04723 Retrograde endocannabinoid signaling 8/129 175/7206 0.0130078868289 ko04916 Melanogenesis 7/129 142/7206 0.0135238159357 ko04371 Apelin signaling pathway 8/129 177/7206 0.0138575436316 ko05033 Nicotine addiction 4/129 56/7206 0.0175756735498 ko04270 Vascular smooth muscle contraction 7/129 154/7206 0.0202753644617 ko04750 Inflammatory mediator regulation of TRP channels 6/129 122/7206 0.0219006625835 ko04742 Taste transduction 4/129 61/7206 0.0233326227143 ko04072 Phospholipase D signaling pathway 8/129 197/7206 0.0247157994478 ko05010 Alzheimer's disease 8/129 202/7206 0.0281676712955 ko02024 Quorum sensing 2/129 15/7206 0.0286732642039 ko04726 Serotonergic synapse 6/129 137/7206 0.0359445070055 ko05032 Morphine addiction 5/129 110/7206 0.0469632169044