ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	104/890	145/7206	2.7223073802e-63
ko03013	RNA transport	82/890	166/7206	2.7944913506e-32
ko04110	Cell cycle	71/890	145/7206	9.85958262792e-28
ko05322	Systemic lupus erythematosus	72/890	151/7206	3.42847052323e-27
ko04111	Cell cycle - yeast	51/890	90/7206	5.22435123137e-24
ko03030	DNA replication	32/890	38/7206	6.90326108595e-24
ko03460	Fanconi anemia pathway	36/890	51/7206	5.35161678382e-22
ko03440	Homologous recombination	32/890	41/7206	6.05220095216e-22
ko03008	Ribosome biogenesis in eukaryotes	41/890	79/7206	1.20357117349e-17
ko05034	Alcoholism	78/890	238/7206	3.76555787974e-17
ko04113	Meiosis - yeast	36/890	70/7206	1.75962486548e-15
ko05203	Viral carcinogenesis	81/890	277/7206	1.72371320408e-14
ko03430	Mismatch repair	18/890	22/7206	1.72506247149e-13
ko03018	RNA degradation	37/890	84/7206	3.60529589006e-13
ko04144	Endocytosis	6/890	342/7206	3.72369968706e-13
ko03420	Nucleotide excision repair	26/890	46/7206	8.38039276003e-13
ko03022	Basal transcription factors	25/890	44/7206	1.97941147693e-12
ko03410	Base excision repair	23/890	38/7206	2.44966356587e-12
ko00240	Pyrimidine metabolism	42/890	110/7206	3.16003847151e-12
ko03015	mRNA surveillance pathway	36/890	93/7206	7.26215250824e-11
ko04060	Cytokine-cytokine receptor interaction	1/890	191/7206	4.16694251197e-10
ko03020	RNA polymerase	17/890	29/7206	3.81597033755e-09
ko04024	cAMP signaling pathway	7/890	279/7206	4.13747045132e-09
ko04810	Regulation of actin cytoskeleton	8/890	264/7206	9.64337290395e-08
ko05010	Alzheimer's disease	4/890	202/7206	1.03364205431e-07
ko04724	Glutamatergic synapse	2/890	152/7206	6.4312622865e-07
ko04270	Vascular smooth muscle contraction	2/890	154/7206	6.63867922881e-07
ko04022	cGMP-PKG signaling pathway	6/890	216/7206	8.43046834727e-07
ko00190	Oxidative phosphorylation	1/890	127/7206	1.73933839208e-06
ko04723	Retrograde endocannabinoid signaling	4/890	175/7206	2.18568376577e-06
ko04010	MAPK signaling pathway	15/890	321/7206	3.27029711771e-06
ko04621	NOD-like receptor signaling pathway	3/890	157/7206	3.37515146666e-06
ko04014	Ras signaling pathway	12/890	279/7206	4.28308627384e-06
ko04510	Focal adhesion	9/890	240/7206	5.18938086803e-06
ko05012	Parkinson's disease	3/890	155/7206	5.20858124889e-06
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/890	182/7206	5.94095709386e-06
ko04151	PI3K-Akt signaling pathway	22/890	390/7206	8.1243374333e-06
ko04921	Oxytocin signaling pathway	7/890	209/7206	8.60365425491e-06
ko04070	Phosphatidylinositol signaling system	1/890	112/7206	8.72494032878e-06
ko05414	Dilated cardiomyopathy	1/890	112/7206	8.72494032878e-06
ko04514	Cell adhesion molecules (CAMs)	2/890	130/7206	1.03543521225e-05
ko04015	Rap1 signaling pathway	13/890	278/7206	1.55291704462e-05
ko04062	Chemokine signaling pathway	7/890	201/7206	1.66971328048e-05
ko05169	Epstein-Barr virus infection	47/890	206/7206	2.12495503514e-05
ko04072	Phospholipase D signaling pathway	7/890	197/7206	2.33854891855e-05
ko04713	Circadian entrainment	3/890	136/7206	3.27156987313e-05
ko04261	Adrenergic signaling in cardiomyocytes	8/890	205/7206	3.56440331067e-05
ko05410	Hypertrophic cardiomyopathy (HCM)	1/890	100/7206	4.42717951944e-05
ko05146	Amoebiasis	1/890	99/7206	4.43564877856e-05
ko04911	Insulin secretion	2/890	117/7206	4.95798786114e-05
ko04120	Ubiquitin mediated proteolysis	34/890	138/7206	6.2088245701e-05
ko04971	Gastric acid secretion	1/890	98/7206	6.84832591539e-05
ko03010	Ribosome	3/890	129/7206	6.93731244372e-05
ko04725	Cholinergic synapse	5/890	160/7206	7.55702085849e-05
ko00230	Purine metabolism	43/890	194/7206	9.3017991249e-05
ko04727	GABAergic synapse	2/890	110/7206	0.000107098061106
ko05032	Morphine addiction	2/890	110/7206	0.000107098061106
ko04972	Pancreatic secretion	2/890	111/7206	0.000109004430229
ko04371	Apelin signaling pathway	7/890	177/7206	0.000177717255892
ko04726	Serotonergic synapse	4/890	137/7206	0.000185302580185
ko00562	Inositol phosphate metabolism	1/890	89/7206	0.000237715126703
ko04360	Axon guidance	12/890	233/7206	0.000246608065808
ko04630	Jak-STAT signaling pathway	4/890	132/7206	0.000258259280386
ko05152	Tuberculosis	8/890	187/7206	0.000261617199375
ko05231	Choline metabolism in cancer	4/890	134/7206	0.000267754837054
ko04114	Oocyte meiosis	32/890	139/7206	0.000370598632782
ko04915	Estrogen signaling pathway	4/890	131/7206	0.00038678429441
ko04721	Synaptic vesicle cycle	1/890	80/7206	0.000494353221482
ko04611	Platelet activation	7/890	163/7206	0.000653920277335
ko04750	Inflammatory mediator regulation of TRP channels	4/890	122/7206	0.000745410750437
ko04066	HIF-1 signaling pathway	4/890	123/7206	0.0007544312185
ko04380	Osteoclast differentiation	5/890	134/7206	0.000822630452266
ko05168	Herpes simplex infection	38/890	182/7206	0.000872047324659
ko04659	Th17 cell differentiation	3/890	106/7206	0.000914126546808
ko04530	Tight junction	13/890	228/7206	0.000997678704792
ko00010	Glycolysis / Gluconeogenesis	1/890	74/7206	0.00110071939795
ko03450	Non-homologous end-joining	7/890	15/7206	0.00112122795523
ko05200	Pathways in cancer	39/890	492/7206	0.00137402135239
ko04924	Renin secretion	2/890	86/7206	0.00154243603194
ko04146	Peroxisome	2/890	89/7206	0.00163414156308
ko05142	Chagas disease (American trypanosomiasis)	5/890	130/7206	0.00168645384642
ko04620	Toll-like receptor signaling pathway	3/890	100/7206	0.00188932241999
ko04728	Dopaminergic synapse	10/890	185/7206	0.00209671320569
ko05145	Toxoplasmosis	5/890	126/7206	0.00230834627134
ko04931	Insulin resistance	6/890	137/7206	0.00231605562026
ko04218	Cellular senescence	36/890	177/7206	0.00238517584022
ko04142	Lysosome	7/890	151/7206	0.00239600918281
ko04670	Leukocyte transendothelial migration	7/890	151/7206	0.00239600918281
ko03050	Proteasome	15/890	54/7206	0.00250824651873
ko04650	Natural killer cell mediated cytotoxicity	3/890	97/7206	0.00271469823363
ko04668	TNF signaling pathway	5/890	120/7206	0.00311634939859
ko04912	GnRH signaling pathway	5/890	122/7206	0.00316510429381
ko04666	Fc gamma R-mediated phagocytosis	5/890	122/7206	0.00316510429381
ko05166	HTLV-I infection	53/890	292/7206	0.00350068913199
ko04925	Aldosterone synthesis and secretion	4/890	105/7206	0.00415705382603
ko03060	Protein export	8/890	23/7206	0.00467071290152
ko04923	Regulation of lipolysis in adipocytes	2/890	77/7206	0.00472091874358
ko05031	Amphetamine addiction	3/890	91/7206	0.00559109148643
ko04712	Circadian rhythm - plant	4/890	7/7206	0.0059420130047
ko04914	Progesterone-mediated oocyte maturation	23/890	104/7206	0.0060879716463
ko01200	Carbon metabolism	6/890	128/7206	0.00609746228553
ko04922	Glucagon signaling pathway	6/890	128/7206	0.00609746228553
ko05030	Cocaine addiction	2/890	73/7206	0.00679620577363
ko05134	Legionellosis	2/890	74/7206	0.00685097931565
ko05140	Leishmaniasis	2/890	75/7206	0.00701330060918
ko04152	AMPK signaling pathway	9/890	161/7206	0.00716342928515
ko05133	Pertussis	3/890	87/7206	0.00779716556158
ko04933	AGE-RAGE signaling pathway in diabetic complications	7/890	135/7206	0.00781660966155
ko04662	B cell receptor signaling pathway	3/890	88/7206	0.00800847308454
ko05132	Salmonella infection	4/890	98/7206	0.00810090879424
ko00564	Glycerophospholipid metabolism	4/890	99/7206	0.00817373083754
ko04660	T cell receptor signaling pathway	6/890	124/7206	0.0082107343061
ko04330	Notch signaling pathway	15/890	62/7206	0.0098661915547
ko04930	Type II diabetes mellitus	1/890	54/7206	0.0116617957697
ko04910	Insulin signaling pathway	11/890	172/7206	0.0134469894504
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	3/890	79/7206	0.0152616016908
ko04512	ECM-receptor interaction	3/890	79/7206	0.0152616016908
ko04730	Long-term depression	3/890	78/7206	0.0152725775324
ko05120	Epithelial cell signaling in Helicobacter pylori infection	4/890	92/7206	0.0156966244038
ko04138	Autophagy - yeast	3/890	81/7206	0.0157886150654
ko05205	Proteoglycans in cancer	21/890	271/7206	0.0182421021101
ko00561	Glycerolipid metabolism	2/890	63/7206	0.0201672206092
ko04115	p53 signaling pathway	16/890	74/7206	0.0204625836182
ko05100	Bacterial invasion of epithelial cells	5/890	99/7206	0.0209269075149
ko04720	Long-term potentiation	5/890	99/7206	0.0209269075149
ko05202	Transcriptional misregulation in cancer	34/890	188/7206	0.0238311166737
ko05160	Hepatitis C	10/890	153/7206	0.0248960762991
ko05204	Chemical carcinogenesis	1/890	48/7206	0.0255013880831
ko04012	ErbB signaling pathway	6/890	109/7206	0.0268207166824
ko05211	Renal cell carcinoma	5/890	96/7206	0.0283411555186
ko04658	Th1 and Th2 cell differentiation	5/890	96/7206	0.0283411555186
ko00670	One carbon pool by folate	6/890	20/7206	0.0293699480657
ko04540	Gap junction	8/890	128/7206	0.0301416523107
ko04918	Thyroid hormone synthesis	4/890	86/7206	0.0301695835418
ko05167	Kaposi's sarcoma-associated herpesvirus infection	14/890	191/7206	0.0334800409766
ko04216	Ferroptosis	1/890	44/7206	0.037167907685
ko04139	Mitophagy - yeast	9/890	37/7206	0.0400835724169
ko05230	Central carbon metabolism in cancer	4/890	81/7206	0.0404497551555
ko04962	Vasopressin-regulated water reabsorption	2/890	58/7206	0.042003320761
ko05164	Influenza A	12/890	167/7206	0.04222194439