ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 18/65 423/7206 1.83743398241e-08 ko04724 Glutamatergic synapse 10/65 152/7206 8.58536521552e-07 ko05030 Cocaine addiction 7/65 73/7206 3.56249053144e-06 ko05033 Nicotine addiction 6/65 56/7206 9.71766996713e-06 ko05031 Amphetamine addiction 7/65 91/7206 1.55805762662e-05 ko04726 Serotonergic synapse 8/65 137/7206 2.81849248012e-05 ko04728 Dopaminergic synapse 8/65 185/7206 0.000234201567471 ko04720 Long-term potentiation 6/65 99/7206 0.000247873073516 ko05034 Alcoholism 9/65 238/7206 0.000255650930319 ko04020 Calcium signaling pathway 9/65 265/7206 0.000563998100768 ko04713 Circadian entrainment 6/65 136/7206 0.00134093476056 ko04730 Long-term depression 4/65 78/7206 0.00521934283221 ko04650 Natural killer cell mediated cytotoxicity 4/65 97/7206 0.0111647189981 ko04014 Ras signaling pathway 7/65 279/7206 0.0123493620383 ko04012 ErbB signaling pathway 4/65 109/7206 0.0165482103315 ko04727 GABAergic synapse 4/65 110/7206 0.0170587447898 ko05032 Morphine addiction 4/65 110/7206 0.0170587447898 ko04360 Axon guidance 6/65 233/7206 0.0180525771325 ko04723 Retrograde endocannabinoid signaling 5/65 175/7206 0.020387128198 ko04540 Gap junction 4/65 128/7206 0.0279704746685 ko05014 Amyotrophic lateral sclerosis (ALS) 3/65 74/7206 0.0288377010392 ko04915 Estrogen signaling pathway 4/65 131/7206 0.030115485587 ko04320 Dorso-ventral axis formation 2/65 31/7206 0.0314946991503 ko04072 Phospholipase D signaling pathway 5/65 197/7206 0.0319278451916 ko05231 Choline metabolism in cancer 4/65 134/7206 0.0323559165548 ko05214 Glioma 3/65 79/7206 0.0340867775372 ko04740 Olfactory transduction 3/65 80/7206 0.0351923661211 ko04015 Rap1 signaling pathway 6/65 278/7206 0.0385222214028 ko04024 cAMP signaling pathway 6/65 279/7206 0.0390974490807 ko04921 Oxytocin signaling pathway 5/65 209/7206 0.0396664101553