ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 11/418 20/7206 2.29773652811e-09 ko03320 PPAR signaling pathway 18/418 69/7206 4.25188742658e-08 ko04710 Circadian rhythm 12/418 43/7206 3.66887932252e-06 ko00592 alpha-Linolenic acid metabolism 8/418 19/7206 5.14273162179e-06 ko00350 Tyrosine metabolism 10/418 33/7206 1.07239718585e-05 ko00360 Phenylalanine metabolism 7/418 17/7206 2.45911525338e-05 ko00071 Fatty acid degradation 11/418 45/7206 3.69911017179e-05 ko04974 Protein digestion and absorption 16/418 96/7206 0.000111435216959 ko00950 Isoquinoline alkaloid biosynthesis 5/418 10/7206 0.000126744836193 ko00590 Arachidonic acid metabolism 11/418 52/7206 0.000152311032577 ko00380 Tryptophan metabolism 10/418 50/7206 0.000489464360504 ko04146 Peroxisome 14/418 89/7206 0.000547207008879 ko00330 Arginine and proline metabolism 11/418 61/7206 0.000657642463928 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/418 4/7206 0.000741958836932 ko00982 Drug metabolism - cytochrome P450 8/418 37/7206 0.00104282483726 ko03013 RNA transport 1/418 166/7206 0.00107232280456 ko00591 Linoleic acid metabolism 6/418 22/7206 0.00123652095067 ko04610 Complement and coagulation cascades 12/418 79/7206 0.00183153817106 ko00140 Steroid hormone biosynthesis 8/418 41/7206 0.00210525760601 ko01212 Fatty acid metabolism 10/418 60/7206 0.0021377562712 ko04144 Endocytosis 8/418 342/7206 0.00284394993733 ko03040 Spliceosome 1/418 145/7206 0.00332193717368 ko04110 Cell cycle 1/418 145/7206 0.00332193717368 ko00362 Benzoate degradation 3/418 6/7206 0.0033974520244 ko04975 Fat digestion and absorption 7/418 35/7206 0.00342757872609 ko00500 Starch and sucrose metabolism 7/418 35/7206 0.00342757872609 ko05204 Chemical carcinogenesis 8/418 48/7206 0.00583078623478 ko04390 Hippo signaling pathway 3/418 188/7206 0.00686044372882 ko03010 Ribosome 1/418 129/7206 0.00688645964202 ko05200 Pathways in cancer 16/418 492/7206 0.00928663781022 ko00561 Glycerolipid metabolism 9/418 63/7206 0.00990531579318 ko05034 Alcoholism 5/418 238/7206 0.0102587053463 ko00052 Galactose metabolism 6/418 33/7206 0.0106917210395 ko00640 Propanoate metabolism 6/418 34/7206 0.0123650464433 ko05203 Viral carcinogenesis 7/418 277/7206 0.0125714088844 ko04270 Vascular smooth muscle contraction 17/418 154/7206 0.0128998809676 ko04972 Pancreatic secretion 13/418 111/7206 0.0129071391359 ko01040 Biosynthesis of unsaturated fatty acids 5/418 25/7206 0.0129830939204 ko04060 Cytokine-cytokine receptor interaction 19/418 191/7206 0.01814982946 ko04672 Intestinal immune network for IgA production 6/418 37/7206 0.0184732027652 ko00643 Styrene degradation 2/418 4/7206 0.0186260925436 ko00260 Glycine, serine and threonine metabolism 7/418 48/7206 0.0196666460002 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/418 11/7206 0.0225498426504 ko04976 Bile secretion 10/418 80/7206 0.0248524676686 ko00980 Metabolism of xenobiotics by cytochrome P450 6/418 40/7206 0.0263772289889 ko05340 Primary immunodeficiency 5/418 30/7206 0.0274840989006 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/418 5/7206 0.0298601693123 ko05100 Bacterial invasion of epithelial cells 1/418 99/7206 0.0302211274016 ko00100 Steroid biosynthesis 4/418 21/7206 0.0304247395877 ko04350 TGF-beta signaling pathway 1/418 103/7206 0.0307440802882 ko00983 Drug metabolism - other enzymes 6/418 42/7206 0.0327334439221 ko00830 Retinol metabolism 6/418 42/7206 0.0327334439221 ko00051 Fructose and mannose metabolism 6/418 42/7206 0.0327334439221 ko00565 Ether lipid metabolism 6/418 42/7206 0.0327334439221 ko04711 Circadian rhythm - fly 3/418 13/7206 0.0358644110673 ko04022 cGMP-PKG signaling pathway 20/418 216/7206 0.0368846337774 ko00480 Glutathione metabolism 7/418 55/7206 0.0384256173148 ko05321 Inflammatory bowel disease (IBD) 7/418 56/7206 0.0418191242378 ko05211 Renal cell carcinoma 1/418 96/7206 0.0442788716333 ko00220 Arginine biosynthesis 4/418 24/7206 0.0471572192759 ko05322 Systemic lupus erythematosus 3/418 151/7206 0.0497212362532