ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1274	423/7206	2.73501053304e-51
ko04724	Glutamatergic synapse	90/1274	152/7206	5.07186348626e-31
ko04713	Circadian entrainment	84/1274	136/7206	6.79109594599e-31
ko05032	Morphine addiction	71/1274	110/7206	5.41243143247e-28
ko05033	Nicotine addiction	47/1274	56/7206	3.0534475288e-27
ko04727	GABAergic synapse	67/1274	110/7206	2.48354996467e-24
ko04725	Cholinergic synapse	80/1274	160/7206	3.46087074705e-21
ko04728	Dopaminergic synapse	87/1274	185/7206	1.1410975679e-20
ko04721	Synaptic vesicle cycle	50/1274	80/7206	3.79456086932e-19
ko04020	Calcium signaling pathway	107/1274	265/7206	1.19472335889e-18
ko04024	cAMP signaling pathway	109/1274	279/7206	6.43091269327e-18
ko04723	Retrograde endocannabinoid signaling	79/1274	175/7206	1.51495760012e-17
ko04911	Insulin secretion	60/1274	117/7206	7.52632633899e-17
ko04742	Taste transduction	39/1274	61/7206	1.0686576259e-15
ko04921	Oxytocin signaling pathway	85/1274	209/7206	3.26139609917e-15
ko04726	Serotonergic synapse	63/1274	137/7206	1.06825837587e-14
ko04970	Salivary secretion	48/1274	95/7206	2.05303587896e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1274	205/7206	2.40208363849e-12
ko03040	Spliceosome	1/1274	145/7206	2.62285304641e-11
ko04720	Long-term potentiation	46/1274	99/7206	2.84898242981e-11
ko05031	Amphetamine addiction	43/1274	91/7206	6.40213025836e-11
ko04022	cGMP-PKG signaling pathway	75/1274	216/7206	1.00188618518e-09
ko04925	Aldosterone synthesis and secretion	45/1274	105/7206	1.25360844702e-09
ko04360	Axon guidance	79/1274	233/7206	1.36696169958e-09
ko04740	Olfactory transduction	37/1274	80/7206	2.94950784646e-09
ko04744	Phototransduction	22/1274	36/7206	7.11109001079e-09
ko04971	Gastric acid secretion	41/1274	98/7206	2.05203734022e-08
ko05203	Viral carcinogenesis	18/1274	277/7206	5.02657582538e-08
ko05322	Systemic lupus erythematosus	5/1274	151/7206	6.88534111955e-08
ko03013	RNA transport	7/1274	166/7206	2.56010595992e-07
ko04730	Long-term depression	32/1274	78/7206	1.25469617874e-06
ko04060	Cytokine-cytokine receptor interaction	11/1274	191/7206	1.71044934268e-06
ko04540	Gap junction	45/1274	128/7206	1.71873689794e-06
ko04924	Renin secretion	34/1274	86/7206	2.27016160559e-06
ko05030	Cocaine addiction	30/1274	73/7206	2.74883279082e-06
ko04010	MAPK signaling pathway	90/1274	321/7206	2.8586091758e-06
ko05164	Influenza A	9/1274	167/7206	2.90036536569e-06
ko05168	Herpes simplex infection	11/1274	182/7206	4.64473175557e-06
ko04514	Cell adhesion molecules (CAMs)	44/1274	130/7206	7.09610751173e-06
ko04972	Pancreatic secretion	39/1274	111/7206	7.92855188353e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1274	74/7206	1.01107949834e-05
ko04371	Apelin signaling pathway	55/1274	177/7206	1.34789338951e-05
ko04070	Phosphatidylinositol signaling system	39/1274	112/7206	1.37733139292e-05
ko04976	Bile secretion	30/1274	80/7206	2.17549537607e-05
ko04014	Ras signaling pathway	77/1274	279/7206	2.76893692958e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1274	59/7206	3.67788274426e-05
ko04072	Phospholipase D signaling pathway	58/1274	197/7206	3.90041435542e-05
ko04621	NOD-like receptor signaling pathway	10/1274	157/7206	4.74092957179e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1274	79/7206	7.27081587662e-05
ko04745	Phototransduction - fly	17/1274	38/7206	9.81620070838e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1274	122/7206	0.000103916425403
ko04923	Regulation of lipolysis in adipocytes	28/1274	77/7206	0.000112127982854
ko04141	Protein processing in endoplasmic reticulum	14/1274	184/7206	0.00011556161844
ko04966	Collecting duct acid secretion	13/1274	26/7206	0.00016422497199
ko04120	Ubiquitin mediated proteolysis	9/1274	138/7206	0.000175015027395
ko04110	Cell cycle	10/1274	145/7206	0.000243199187397
ko05110	Vibrio cholerae infection	23/1274	63/7206	0.000342215696653
ko05169	Epstein-Barr virus infection	18/1274	206/7206	0.000385588847538
ko05414	Dilated cardiomyopathy	35/1274	112/7206	0.000401889764253
ko04612	Antigen processing and presentation	3/1274	77/7206	0.000442978949061
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1274	79/7206	0.00048570447964
ko05162	Measles	8/1274	120/7206	0.000647070100746
ko05140	Leishmaniasis	3/1274	75/7206	0.000652482337112
ko04260	Cardiac muscle contraction	31/1274	98/7206	0.000718816449104
ko05205	Proteoglycans in cancer	28/1274	271/7206	0.000829188380714
ko00330	Arginine and proline metabolism	2/1274	61/7206	0.00112014593463
ko04915	Estrogen signaling pathway	38/1274	131/7206	0.00113986509633
ko04146	Peroxisome	5/1274	89/7206	0.00117995159343
ko04610	Complement and coagulation cascades	4/1274	79/7206	0.0015729305768
ko04626	Plant-pathogen interaction	9/1274	18/7206	0.00172374299194
ko04064	NF-kappa B signaling pathway	6/1274	96/7206	0.00173010877854
ko04710	Circadian rhythm	16/1274	43/7206	0.00204659802199
ko00240	Pyrimidine metabolism	8/1274	110/7206	0.00233179823346
ko04964	Proximal tubule bicarbonate reclamation	12/1274	29/7206	0.00237364154251
ko00071	Fatty acid degradation	1/1274	45/7206	0.00273024841756
ko03420	Nucleotide excision repair	1/1274	46/7206	0.00282304476184
ko00310	Lysine degradation	4/1274	73/7206	0.00319047007701
ko04711	Circadian rhythm - fly	7/1274	13/7206	0.00337749106972
ko00480	Glutathione metabolism	2/1274	55/7206	0.00374183452217
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1274	182/7206	0.00413846366273
ko04622	RIG-I-like receptor signaling pathway	3/1274	62/7206	0.0042098606235
ko03022	Basal transcription factors	1/1274	44/7206	0.00435775303212
ko04270	Vascular smooth muscle contraction	41/1274	154/7206	0.00522621512219
ko00590	Arachidonic acid metabolism	2/1274	52/7206	0.00537855250334
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1274	14/7206	0.00573346565654
ko04930	Type II diabetes mellitus	18/1274	54/7206	0.00606509622911
ko04657	IL-17 signaling pathway	6/1274	87/7206	0.0065720207245
ko05133	Pertussis	6/1274	87/7206	0.0065720207245
ko04217	Necroptosis	18/1274	178/7206	0.00690802423644
ko00380	Tryptophan metabolism	2/1274	50/7206	0.00799452671949
ko04912	GnRH signaling pathway	33/1274	122/7206	0.00837463130861
ko03018	RNA degradation	6/1274	84/7206	0.00893153778124
ko03410	Base excision repair	1/1274	38/7206	0.00939505424473
ko04918	Thyroid hormone synthesis	25/1274	86/7206	0.00963667669016
ko01200	Carbon metabolism	12/1274	128/7206	0.0100466521489
ko04015	Rap1 signaling pathway	66/1274	278/7206	0.0100503125275
ko04916	Melanogenesis	37/1274	142/7206	0.0105374973721
ko05161	Hepatitis B	18/1274	173/7206	0.0112395877144
ko00260	Glycine, serine and threonine metabolism	2/1274	48/7206	0.0118999166038
ko05131	Shigellosis	6/1274	82/7206	0.0123866611386
ko04214	Apoptosis - fly	5/1274	72/7206	0.0126095130198
ko05321	Inflammatory bowel disease (IBD)	3/1274	56/7206	0.0126173952346
ko04115	p53 signaling pathway	5/1274	74/7206	0.0130933166109
ko04922	Glucagon signaling pathway	34/1274	128/7206	0.0134316343428
ko00500	Starch and sucrose metabolism	1/1274	35/7206	0.014144061238
ko04658	Th1 and Th2 cell differentiation	8/1274	96/7206	0.0145715561045
ko05144	Malaria	2/1274	45/7206	0.0169480811719
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1274	100/7206	0.0174057527282
ko00280	Valine, leucine and isoleucine degradation	3/1274	54/7206	0.0182302086144
ko05231	Choline metabolism in cancer	34/1274	134/7206	0.0221141218775
ko05166	HTLV-I infection	37/1274	292/7206	0.0228485298533
ko04620	Toll-like receptor signaling pathway	9/1274	100/7206	0.0237698735052
ko03320	PPAR signaling pathway	5/1274	69/7206	0.0247872653553
ko04630	Jak-STAT signaling pathway	14/1274	132/7206	0.0287739190175
ko05016	Huntington's disease	26/1274	215/7206	0.0291250737005
ko05145	Toxoplasmosis	13/1274	126/7206	0.0329976193746
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1274	40/7206	0.0355438061154
ko04071	Sphingolipid signaling pathway	39/1274	162/7206	0.0367844162719
ko04973	Carbohydrate digestion and absorption	13/1274	42/7206	0.0391249807507
ko04142	Lysosome	17/1274	151/7206	0.0398211596973
ko04113	Meiosis - yeast	6/1274	70/7206	0.0412778981717
ko05012	Parkinson's disease	18/1274	155/7206	0.0434183036596
ko04640	Hematopoietic cell lineage	5/1274	64/7206	0.0460967218455
ko04722	Neurotrophin signaling pathway	38/1274	160/7206	0.0463580399221
ko01524	Platinum drug resistance	7/1274	76/7206	0.0498909742407