ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	150/808	423/7206	1.06965204481e-42
ko05033	Nicotine addiction	47/808	56/7206	1.81622482628e-36
ko04724	Glutamatergic synapse	77/808	152/7206	2.81348443647e-34
ko04727	GABAergic synapse	55/808	110/7206	2.4328343082e-24
ko05032	Morphine addiction	55/808	110/7206	2.4328343082e-24
ko04728	Dopaminergic synapse	71/808	185/7206	1.69452575312e-22
ko04713	Circadian entrainment	58/808	136/7206	3.22465387307e-21
ko04723	Retrograde endocannabinoid signaling	66/808	175/7206	1.72511419168e-20
ko04725	Cholinergic synapse	59/808	160/7206	7.16299721197e-18
ko04024	cAMP signaling pathway	81/808	279/7206	7.74138805407e-17
ko04721	Synaptic vesicle cycle	38/808	80/7206	3.29189273473e-16
ko04911	Insulin secretion	47/808	117/7206	3.68237499018e-16
ko04020	Calcium signaling pathway	72/808	265/7206	2.01819648041e-13
ko05031	Amphetamine addiction	37/808	91/7206	3.5301929439e-13
ko04720	Long-term potentiation	37/808	99/7206	7.36292299515e-12
ko04726	Serotonergic synapse	45/808	137/7206	7.40001946643e-12
ko04261	Adrenergic signaling in cardiomyocytes	57/808	205/7206	4.37684543536e-11
ko04742	Taste transduction	27/808	61/7206	5.43950448422e-11
ko04921	Oxytocin signaling pathway	57/808	209/7206	7.12906007316e-11
ko05030	Cocaine addiction	28/808	73/7206	1.35745010354e-09
ko04970	Salivary secretion	31/808	95/7206	1.70345248638e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	26/808	74/7206	4.45603046893e-08
ko04925	Aldosterone synthesis and secretion	32/808	105/7206	6.31619172011e-08
ko04010	MAPK signaling pathway	68/808	321/7206	1.55499911101e-07
ko04514	Cell adhesion molecules (CAMs)	35/808	130/7206	6.24732526776e-07
ko03040	Spliceosome	1/808	145/7206	8.45869676632e-07
ko04972	Pancreatic secretion	31/808	111/7206	8.77149125223e-07
ko05203	Viral carcinogenesis	9/808	277/7206	1.45340132897e-06
ko04971	Gastric acid secretion	28/808	98/7206	1.80288943577e-06
ko05168	Herpes simplex infection	4/808	182/7206	7.46911154273e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/808	79/7206	1.06363262231e-05
ko04744	Phototransduction	14/808	36/7206	1.5764639816e-05
ko04060	Cytokine-cytokine receptor interaction	5/808	191/7206	2.01145915053e-05
ko04260	Cardiac muscle contraction	26/808	98/7206	2.62363199405e-05
ko04360	Axon guidance	48/808	233/7206	2.93123655507e-05
ko05164	Influenza A	4/808	167/7206	3.23918522785e-05
ko04022	cGMP-PKG signaling pathway	44/808	216/7206	6.59607723638e-05
ko04072	Phospholipase D signaling pathway	41/808	197/7206	7.68705316084e-05
ko04730	Long-term depression	21/808	78/7206	9.12362171639e-05
ko05322	Systemic lupus erythematosus	4/808	151/7206	0.000201844760246
ko04740	Olfactory transduction	21/808	80/7206	0.000205250836119
ko04621	NOD-like receptor signaling pathway	5/808	157/7206	0.000456078952041
ko04141	Protein processing in endoplasmic reticulum	7/808	184/7206	0.00051143020905
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/808	59/7206	0.000562237239545
ko05162	Measles	3/808	120/7206	0.000680741737237
ko05414	Dilated cardiomyopathy	25/808	112/7206	0.000689241689053
ko04964	Proximal tubule bicarbonate reclamation	10/808	29/7206	0.000808938431585
ko04976	Bile secretion	19/808	80/7206	0.00114238253784
ko04110	Cell cycle	5/808	145/7206	0.00123419345421
ko04612	Antigen processing and presentation	1/808	77/7206	0.00173544482353
ko04915	Estrogen signaling pathway	27/808	131/7206	0.00177300502678
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/808	182/7206	0.00178377469315
ko04745	Phototransduction - fly	11/808	38/7206	0.00228403613521
ko03013	RNA transport	7/808	166/7206	0.00251239376278
ko04540	Gap junction	26/808	128/7206	0.00257662151982
ko04924	Renin secretion	19/808	86/7206	0.00305058970769
ko04630	Jak-STAT signaling pathway	5/808	132/7206	0.00328444191421
ko05169	Epstein-Barr virus infection	11/808	206/7206	0.00482304257756
ko04973	Carbohydrate digestion and absorption	11/808	42/7206	0.00535320040878
ko04120	Ubiquitin mediated proteolysis	6/808	138/7206	0.00620830349017
ko04014	Ras signaling pathway	46/808	279/7206	0.00652123572901
ko04930	Type II diabetes mellitus	13/808	54/7206	0.00719557048862
ko05205	Proteoglycans in cancer	17/808	271/7206	0.00771423842441
ko04140	Autophagy - animal	8/808	164/7206	0.00795167034119
ko04640	Hematopoietic cell lineage	1/808	64/7206	0.00836684010296
ko05410	Hypertrophic cardiomyopathy (HCM)	20/808	100/7206	0.00958222329305
ko03008	Ribosome biogenesis in eukaryotes	2/808	79/7206	0.0105833347845
ko04750	Inflammatory mediator regulation of TRP channels	23/808	122/7206	0.0127772521488
ko00310	Lysine degradation	2/808	73/7206	0.0146445641783
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/808	14/7206	0.014749433881
ko04070	Phosphatidylinositol signaling system	21/808	112/7206	0.0153098967039
ko04217	Necroptosis	10/808	178/7206	0.0154312150008
ko04146	Peroxisome	3/808	89/7206	0.0163289393148
ko04350	TGF-beta signaling pathway	4/808	103/7206	0.0168089248173
ko04550	Signaling pathways regulating pluripotency of stem cells	9/808	165/7206	0.0168789015776
ko00480	Glutathione metabolism	1/808	55/7206	0.0178664373583
ko05161	Hepatitis B	10/808	173/7206	0.0198812066863
ko04966	Collecting duct acid secretion	7/808	26/7206	0.0211427211301
ko05034	Alcoholism	38/808	238/7206	0.0214816548231
ko00240	Pyrimidine metabolism	5/808	110/7206	0.0216664445135
ko05215	Prostate cancer	5/808	111/7206	0.0218214944832
ko04214	Apoptosis - fly	2/808	72/7206	0.0218481974794
ko04064	NF-kappa B signaling pathway	4/808	96/7206	0.0222474203962
ko03018	RNA degradation	3/808	84/7206	0.0223188159287
ko05166	HTLV-I infection	21/808	292/7206	0.0231091474993
ko04918	Thyroid hormone synthesis	17/808	86/7206	0.0232566517785
ko04150	mTOR signaling pathway	11/808	184/7206	0.0236070166195
ko04210	Apoptosis	11/808	180/7206	0.0302501476213
ko00512	Mucin type O-glycan biosynthesis	7/808	29/7206	0.0373574788484
ko00260	Glycine, serine and threonine metabolism	1/808	48/7206	0.0382829753549
ko05219	Bladder cancer	1/808	48/7206	0.0382829753549
ko04978	Mineral absorption	9/808	40/7206	0.0384529550121
ko04015	Rap1 signaling pathway	42/808	278/7206	0.0413824753372
ko04912	GnRH signaling pathway	21/808	122/7206	0.0418114804789
ko04330	Notch signaling pathway	2/808	62/7206	0.0422310515113
ko04960	Aldosterone-regulated sodium reabsorption	9/808	41/7206	0.0422506841685
ko05140	Leishmaniasis	3/808	75/7206	0.0427744522655
ko01524	Platinum drug resistance	3/808	76/7206	0.0429199478384
ko04626	Plant-pathogen interaction	5/808	18/7206	0.0433077937621