ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	210/1264	423/7206	1.74053975037e-55
ko04724	Glutamatergic synapse	91/1264	152/7206	3.65089489121e-32
ko05033	Nicotine addiction	48/1264	56/7206	8.12970142091e-29
ko05032	Morphine addiction	69/1264	110/7206	2.42761327664e-26
ko04713	Circadian entrainment	77/1264	136/7206	3.85557969465e-25
ko04727	GABAergic synapse	67/1264	110/7206	1.55069426529e-24
ko04721	Synaptic vesicle cycle	55/1264	80/7206	3.81964278349e-24
ko04725	Cholinergic synapse	77/1264	160/7206	2.27039586457e-19
ko04728	Dopaminergic synapse	84/1264	185/7206	5.21943749166e-19
ko04020	Calcium signaling pathway	105/1264	265/7206	4.95726060232e-18
ko04024	cAMP signaling pathway	108/1264	279/7206	1.10810723339e-17
ko04723	Retrograde endocannabinoid signaling	78/1264	175/7206	3.78200770139e-17
ko04742	Taste transduction	39/1264	61/7206	8.10790550951e-16
ko04911	Insulin secretion	58/1264	117/7206	1.2774433801e-15
ko04921	Oxytocin signaling pathway	83/1264	209/7206	1.54996019319e-14
ko04744	Phototransduction	27/1264	36/7206	5.66393755154e-14
ko04726	Serotonergic synapse	61/1264	137/7206	1.20674500252e-13
ko04970	Salivary secretion	45/1264	95/7206	1.55933520672e-11
ko04720	Long-term potentiation	46/1264	99/7206	2.14816981511e-11
ko04740	Olfactory transduction	40/1264	80/7206	2.52993396396e-11
ko03040	Spliceosome	1/1264	145/7206	2.61233418494e-11
ko04261	Adrenergic signaling in cardiomyocytes	75/1264	205/7206	3.83578645493e-11
ko05031	Amphetamine addiction	41/1264	91/7206	8.63204490754e-10
ko05168	Herpes simplex infection	6/1264	182/7206	4.26097817194e-09
ko04360	Axon guidance	76/1264	233/7206	1.25562641611e-08
ko05203	Viral carcinogenesis	17/1264	277/7206	1.83951458049e-08
ko04060	Cytokine-cytokine receptor interaction	9/1264	191/7206	1.15696773801e-07
ko04971	Gastric acid secretion	39/1264	98/7206	1.49893219873e-07
ko04925	Aldosterone synthesis and secretion	41/1264	105/7206	1.61661191102e-07
ko03013	RNA transport	7/1264	166/7206	2.50843931224e-07
ko04022	cGMP-PKG signaling pathway	68/1264	216/7206	3.96147895329e-07
ko04540	Gap junction	46/1264	128/7206	4.62503388422e-07
ko04966	Collecting duct acid secretion	16/1264	26/7206	6.66066396227e-07
ko04120	Ubiquitin mediated proteolysis	5/1264	138/7206	7.2773727872e-07
ko05164	Influenza A	8/1264	167/7206	8.98112879785e-07
ko05322	Systemic lupus erythematosus	7/1264	151/7206	2.32504345858e-06
ko05030	Cocaine addiction	30/1264	73/7206	2.49940537233e-06
ko04621	NOD-like receptor signaling pathway	8/1264	157/7206	3.81833388843e-06
ko04924	Renin secretion	33/1264	86/7206	4.50983649681e-06
ko04260	Cardiac muscle contraction	36/1264	98/7206	5.39678281567e-06
ko04972	Pancreatic secretion	39/1264	111/7206	6.84305382081e-06
ko05169	Epstein-Barr virus infection	14/1264	206/7206	9.72418218137e-06
ko04730	Long-term depression	30/1264	78/7206	1.3706208452e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1264	74/7206	3.51410377013e-05
ko04514	Cell adhesion molecules (CAMs)	42/1264	130/7206	3.52415105664e-05
ko04010	MAPK signaling pathway	85/1264	321/7206	4.49331818846e-05
ko04141	Protein processing in endoplasmic reticulum	13/1264	184/7206	4.74790628402e-05
ko04610	Complement and coagulation cascades	2/1264	79/7206	7.08137965142e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1264	79/7206	7.08137965142e-05
ko04976	Bile secretion	29/1264	80/7206	7.61917339958e-05
ko05162	Measles	6/1264	120/7206	8.02553178996e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1264	59/7206	8.76805815333e-05
ko05110	Vibrio cholerae infection	24/1264	63/7206	8.82357037988e-05
ko04745	Phototransduction - fly	17/1264	38/7206	8.86142238638e-05
ko04110	Cell cycle	9/1264	145/7206	9.19819728456e-05
ko05140	Leishmaniasis	2/1264	75/7206	0.000103750013802
ko04064	NF-kappa B signaling pathway	4/1264	96/7206	0.000119915090324
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1264	79/7206	0.000133992666255
ko04964	Proximal tubule bicarbonate reclamation	14/1264	29/7206	0.000136369650486
ko04146	Peroxisome	4/1264	89/7206	0.000367254436628
ko05414	Dilated cardiomyopathy	35/1264	112/7206	0.000372103386965
ko04014	Ras signaling pathway	72/1264	279/7206	0.000390844337214
ko04612	Antigen processing and presentation	3/1264	77/7206	0.00044792744534
ko05161	Hepatitis B	14/1264	173/7206	0.000519851846072
ko00480	Glutathione metabolism	1/1264	55/7206	0.00052317834347
ko05205	Proteoglycans in cancer	27/1264	271/7206	0.00058327851282
ko04371	Apelin signaling pathway	49/1264	177/7206	0.000629468309651
ko04072	Phospholipase D signaling pathway	53/1264	197/7206	0.000836577919981
ko00240	Pyrimidine metabolism	7/1264	110/7206	0.000904523025715
ko05166	HTLV-I infection	31/1264	292/7206	0.000946246577979
ko04214	Apoptosis - fly	3/1264	72/7206	0.000959152079332
ko04070	Phosphatidylinositol signaling system	34/1264	112/7206	0.000962044311051
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1264	14/7206	0.000967271643216
ko04750	Inflammatory mediator regulation of TRP channels	36/1264	122/7206	0.00104721976678
ko04626	Plant-pathogen interaction	9/1264	18/7206	0.00162654009486
ko01524	Platinum drug resistance	4/1264	76/7206	0.00225435960369
ko04668	TNF signaling pathway	9/1264	120/7206	0.00226881541475
ko05321	Inflammatory bowel disease (IBD)	2/1264	56/7206	0.00248221624114
ko00071	Fatty acid degradation	1/1264	45/7206	0.00274951026622
ko03420	Nucleotide excision repair	1/1264	46/7206	0.00279687627584
ko05145	Toxoplasmosis	10/1264	126/7206	0.00290476343423
ko04923	Regulation of lipolysis in adipocytes	24/1264	77/7206	0.00363075678177
ko03022	Basal transcription factors	1/1264	44/7206	0.00429713938709
ko00310	Lysine degradation	4/1264	73/7206	0.00469827706943
ko05131	Shigellosis	5/1264	82/7206	0.00489233898887
ko04915	Estrogen signaling pathway	36/1264	131/7206	0.00500367390386
ko00590	Arachidonic acid metabolism	2/1264	52/7206	0.00537411226
ko04350	TGF-beta signaling pathway	8/1264	103/7206	0.0059408105005
ko04622	RIG-I-like receptor signaling pathway	3/1264	62/7206	0.0063312131515
ko04658	Th1 and Th2 cell differentiation	7/1264	96/7206	0.00633992678128
ko04657	IL-17 signaling pathway	6/1264	87/7206	0.00650957463289
ko05133	Pertussis	6/1264	87/7206	0.00650957463289
ko04270	Vascular smooth muscle contraction	40/1264	154/7206	0.00730324143658
ko00380	Tryptophan metabolism	2/1264	50/7206	0.00794563990684
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1264	100/7206	0.00795179023265
ko03018	RNA degradation	6/1264	84/7206	0.00891190309767
ko00630	Glyoxylate and dicarboxylate metabolism	1/1264	38/7206	0.00943617397791
ko03410	Base excision repair	1/1264	38/7206	0.00943617397791
ko04620	Toll-like receptor signaling pathway	8/1264	100/7206	0.011103974119
ko05418	Fluid shear stress and atherosclerosis	18/1264	173/7206	0.0111271750888
ko04115	p53 signaling pathway	5/1264	74/7206	0.0129150481452
ko04912	GnRH signaling pathway	32/1264	122/7206	0.0157048079502
ko05222	Small cell lung cancer	7/1264	89/7206	0.0160746340484
ko05144	Malaria	2/1264	45/7206	0.0168941649342
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1264	182/7206	0.0175162681526
ko04330	Notch signaling pathway	4/1264	62/7206	0.0180311212384
ko04916	Melanogenesis	36/1264	142/7206	0.0186626675138
ko04630	Jak-STAT signaling pathway	13/1264	132/7206	0.0201346952137
ko04210	Apoptosis	20/1264	180/7206	0.0219700490019
ko00562	Inositol phosphate metabolism	24/1264	89/7206	0.0242104721182
ko00330	Arginine and proline metabolism	4/1264	61/7206	0.0260382930961
ko04217	Necroptosis	20/1264	178/7206	0.0275179565306
ko05212	Pancreatic cancer	7/1264	83/7206	0.0284181891668
ko05132	Salmonella infection	9/1264	98/7206	0.0312230204631
ko05215	Prostate cancer	11/1264	111/7206	0.0321182023146
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1264	40/7206	0.0354958843853
ko00260	Glycine, serine and threonine metabolism	3/1264	48/7206	0.0359411936901
ko00910	Nitrogen metabolism	7/1264	19/7206	0.0360106304807
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1264	92/7206	0.0376311333399
ko04974	Protein digestion and absorption	25/1264	96/7206	0.0412963108452
ko00600	Sphingolipid metabolism	5/1264	63/7206	0.0450188124246
ko05206	MicroRNAs in cancer	21/1264	177/7206	0.0451300375207
ko04640	Hematopoietic cell lineage	5/1264	64/7206	0.0456672002042
ko04140	Autophagy - animal	19/1264	164/7206	0.0477131653041
ko05320	Autoimmune thyroid disease	1/1264	29/7206	0.0478611982033
ko00280	Valine, leucine and isoleucine degradation	4/1264	54/7206	0.0482284317702
ko05340	Primary immunodeficiency	1/1264	30/7206	0.0496402626879