ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1137	423/7206	6.50899554069e-55
ko04724	Glutamatergic synapse	89/1137	152/7206	4.06243225741e-34
ko05033	Nicotine addiction	48/1137	56/7206	5.36951638672e-31
ko04713	Circadian entrainment	75/1137	136/7206	1.50168115335e-26
ko04727	GABAergic synapse	66/1137	110/7206	2.21214841791e-26
ko05032	Morphine addiction	66/1137	110/7206	2.21214841791e-26
ko04721	Synaptic vesicle cycle	54/1137	80/7206	1.9637341241e-25
ko04725	Cholinergic synapse	76/1137	160/7206	1.46923325424e-21
ko04728	Dopaminergic synapse	82/1137	185/7206	9.24333211634e-21
ko04723	Retrograde endocannabinoid signaling	77/1137	175/7206	2.54389404888e-19
ko04024	cAMP signaling pathway	101/1137	279/7206	1.45703012273e-17
ko04020	Calcium signaling pathway	96/1137	265/7206	9.68538309889e-17
ko04911	Insulin secretion	56/1137	117/7206	2.27893028709e-16
ko04921	Oxytocin signaling pathway	80/1137	209/7206	1.17034440037e-15
ko04742	Taste transduction	37/1137	61/7206	1.58074837642e-15
ko04726	Serotonergic synapse	59/1137	137/7206	1.48473232007e-14
ko04744	Phototransduction	26/1137	36/7206	5.6114444218e-14
ko04720	Long-term potentiation	46/1137	99/7206	4.45950209744e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1137	205/7206	6.79470096751e-13
ko04970	Salivary secretion	44/1137	95/7206	1.66717712966e-12
ko04740	Olfactory transduction	39/1137	80/7206	4.1912275936e-12
ko05031	Amphetamine addiction	42/1137	91/7206	6.2204152317e-12
ko03040	Spliceosome	1/1137	145/7206	5.16597985884e-10
ko04925	Aldosterone synthesis and secretion	41/1137	105/7206	5.77987562864e-09
ko04971	Gastric acid secretion	38/1137	98/7206	2.61543623234e-08
ko04060	Cytokine-cytokine receptor interaction	6/1137	191/7206	2.69432186155e-08
ko05203	Viral carcinogenesis	14/1137	277/7206	2.94388919807e-08
ko04022	cGMP-PKG signaling pathway	66/1137	216/7206	3.49216249887e-08
ko05168	Herpes simplex infection	6/1137	182/7206	8.29466236343e-08
ko04360	Axon guidance	68/1137	233/7206	1.31787954503e-07
ko05030	Cocaine addiction	29/1137	73/7206	6.45394817703e-07
ko04745	Phototransduction - fly	19/1137	38/7206	8.73265653451e-07
ko04260	Cardiac muscle contraction	35/1137	98/7206	9.96246315428e-07
ko04966	Collecting duct acid secretion	15/1137	26/7206	1.1799893731e-06
ko04924	Renin secretion	32/1137	86/7206	1.32925313444e-06
ko04120	Ubiquitin mediated proteolysis	4/1137	138/7206	1.4752706815e-06
ko04010	MAPK signaling pathway	83/1137	321/7206	2.09116304995e-06
ko04540	Gap junction	41/1137	128/7206	3.63602670002e-06
ko03013	RNA transport	7/1137	166/7206	4.1487242557e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1137	79/7206	5.49102475594e-06
ko05322	Systemic lupus erythematosus	6/1137	151/7206	7.38021776888e-06
ko04972	Pancreatic secretion	36/1137	111/7206	9.84828540734e-06
ko04730	Long-term depression	28/1137	78/7206	1.1720918383e-05
ko04621	NOD-like receptor signaling pathway	7/1137	157/7206	1.1973248569e-05
ko05164	Influenza A	8/1137	167/7206	1.32541309221e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1137	74/7206	1.32819725391e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1137	59/7206	1.34146897095e-05
ko05110	Vibrio cholerae infection	24/1137	63/7206	1.38705240197e-05
ko05414	Dilated cardiomyopathy	36/1137	112/7206	1.78692299535e-05
ko04141	Protein processing in endoplasmic reticulum	10/1137	184/7206	2.09971749795e-05
ko05169	Epstein-Barr virus infection	13/1137	206/7206	4.05773933755e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1137	122/7206	4.48150163072e-05
ko04014	Ras signaling pathway	70/1137	279/7206	5.01256432648e-05
ko04612	Antigen processing and presentation	1/1137	77/7206	5.03148554377e-05
ko04110	Cell cycle	7/1137	145/7206	7.04925276131e-05
ko04514	Cell adhesion molecules (CAMs)	38/1137	130/7206	8.34507748871e-05
ko04072	Phospholipase D signaling pathway	52/1137	197/7206	9.81589277706e-05
ko05162	Measles	5/1137	120/7206	0.00011537432418
ko04626	Plant-pathogen interaction	10/1137	18/7206	0.000119190109658
ko04976	Bile secretion	26/1137	80/7206	0.000162246323167
ko04610	Complement and coagulation cascades	2/1137	79/7206	0.000265875040834
ko03008	Ribosome biogenesis in eukaryotes	2/1137	79/7206	0.000265875040834
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1137	14/7206	0.000461189601955
ko04915	Estrogen signaling pathway	36/1137	131/7206	0.000599069031736
ko04064	NF-kappa B signaling pathway	4/1137	96/7206	0.000599675359149
ko05140	Leishmaniasis	2/1137	75/7206	0.000610857586426
ko04214	Apoptosis - fly	2/1137	72/7206	0.000884323537988
ko00520	Amino sugar and nucleotide sugar metabolism	1/1137	55/7206	0.00133992364947
ko00480	Glutathione metabolism	1/1137	55/7206	0.00133992364947
ko05161	Hepatitis B	13/1137	173/7206	0.00145793319508
ko04912	GnRH signaling pathway	33/1137	122/7206	0.00151156151294
ko04371	Apelin signaling pathway	44/1137	177/7206	0.00159651194649
ko05205	Proteoglycans in cancer	25/1137	271/7206	0.00211377489399
ko04070	Phosphatidylinositol signaling system	30/1137	112/7206	0.00245014708691
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1137	100/7206	0.00347999673601
ko04923	Regulation of lipolysis in adipocytes	22/1137	77/7206	0.00409584864736
ko04146	Peroxisome	5/1137	89/7206	0.00511265360545
ko04916	Melanogenesis	35/1137	142/7206	0.00511625322766
ko05166	HTLV-I infection	30/1137	292/7206	0.00679496765082
ko05144	Malaria	1/1137	45/7206	0.00680510854519
ko00071	Fatty acid degradation	1/1137	45/7206	0.00680510854519
ko03420	Nucleotide excision repair	1/1137	46/7206	0.00696868479933
ko04657	IL-17 signaling pathway	5/1137	87/7206	0.00714632026701
ko05321	Inflammatory bowel disease (IBD)	2/1137	56/7206	0.00871292652886
ko04350	TGF-beta signaling pathway	7/1137	103/7206	0.00919677977014
ko03018	RNA degradation	5/1137	84/7206	0.00986812325817
ko01524	Platinum drug resistance	4/1137	76/7206	0.0102441488502
ko03022	Basal transcription factors	1/1137	44/7206	0.0107364915802
ko04668	TNF signaling pathway	9/1137	120/7206	0.0109088857913
ko00240	Pyrimidine metabolism	8/1137	110/7206	0.0116689605747
ko00590	Arachidonic acid metabolism	2/1137	52/7206	0.0123695923272
ko05145	Toxoplasmosis	10/1137	126/7206	0.0131295473573
ko04270	Vascular smooth muscle contraction	36/1137	154/7206	0.0133940156643
ko04330	Notch signaling pathway	3/1137	62/7206	0.0134658762423
ko04622	RIG-I-like receptor signaling pathway	3/1137	62/7206	0.0134658762423
ko05131	Shigellosis	5/1137	82/7206	0.0137676464013
ko00310	Lysine degradation	4/1137	73/7206	0.0141743862393
ko05418	Fluid shear stress and atherosclerosis	16/1137	173/7206	0.0149505963112
ko04630	Jak-STAT signaling pathway	11/1137	132/7206	0.0155689517329
ko04210	Apoptosis	17/1137	180/7206	0.0168861932151
ko04964	Proximal tubule bicarbonate reclamation	10/1137	29/7206	0.0172362451658
ko04922	Glucagon signaling pathway	30/1137	128/7206	0.0200372657011
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1137	92/7206	0.020421701018
ko04217	Necroptosis	17/1137	178/7206	0.0214241759573
ko04930	Type II diabetes mellitus	15/1137	54/7206	0.0228504459567
ko04658	Th1 and Th2 cell differentiation	7/1137	96/7206	0.0228860445045
ko00630	Glyoxylate and dicarboxylate metabolism	1/1137	38/7206	0.0230517957613
ko03410	Base excision repair	1/1137	38/7206	0.0230517957613
ko04015	Rap1 signaling pathway	58/1137	278/7206	0.0230873084822
ko04114	Oocyte meiosis	32/1137	139/7206	0.0247912328959
ko05215	Prostate cancer	9/1137	111/7206	0.0249037057182
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1137	182/7206	0.0298642954389
ko05212	Pancreatic cancer	6/1137	83/7206	0.0326804666146
ko00860	Porphyrin and chlorophyll metabolism	1/1137	34/7206	0.0336667921212
ko00500	Starch and sucrose metabolism	1/1137	35/7206	0.0339286487877
ko04115	p53 signaling pathway	5/1137	74/7206	0.0354130857608
ko00600	Sphingolipid metabolism	4/1137	63/7206	0.036757913436
ko04620	Toll-like receptor signaling pathway	8/1137	100/7206	0.036800108222
ko04722	Neurotrophin signaling pathway	35/1137	160/7206	0.0370039394651
ko04640	Hematopoietic cell lineage	4/1137	64/7206	0.0370830085336
ko05222	Small cell lung cancer	7/1137	89/7206	0.039694407848
ko05231	Choline metabolism in cancer	30/1137	134/7206	0.0413064987758
ko04071	Sphingolipid signaling pathway	35/1137	162/7206	0.0489086412471